■ 氏名
宇高 恵子 (ウダカ ケイコ)
UDAKA Keiko

■ 所属部局/職名
Research and Education Faculty, Medical Sciences Cluster, Basic Medicine Unit/Professor
教育研究部 医療学系 基礎医学部門/教授

■ 学部・学科・コース等
Medical School, Medical Course, Department of Immunology
医学部 医学科 免疫学

■ 連絡先
住 所
電 話088-880-2317
F A X088-880-2320
E-Mailudaka●kochi-u.ac.jp    (送信の際は“●”を半角の“@”に変更して送信してください。)
U R L

■ 出身大学院・研究科等
愛媛大学 ( ) ()

■ 出身学校・専攻等

■ 取得学位
医学博士 ()

■ 研究職歴

■ 委員歴・役員歴

■ 受賞学術賞

■ 所属学会
日本免疫学会
 ( 国内)
日本生物物理学会
 ( 国内)
造血器腫瘍免疫療法研究会
 ( 国内)
日本がん免疫学会
 ( 国内)

■ 専門分野
免疫分子認識

■ 主な研究テーマ・活動
T細胞認識

■ 研究についてのPR
T細胞による自己、非自己の見分けの分子機構を明らかにしたい。特に、抗原認識が起こる細胞膜という反応場の特性を理解し、場の変化による認識効率の違いに注目して研究を進めている。実用面では、これまでに開発してきた、T細胞に抗原を提示するMHC分子に結合する抗原ペプチドの同定技術を生かして、悪性腫瘍の標的免疫療法の開発や、アレルギーの抑制技術の開発を行っている。

■ 社会人・生徒を対象として可能な講演・授業(例えば講演題目)

■ 研究業績(論文・解説)
○Lipid-mediated presentation of MHC class II molecules guides thymocytes to the CD4 lineage. 
 Eur J Immunol (Komaniwa S., Hayashi H., Kawamoto H., Sato S.B., Ikawa T., Katsura Y. and Udaka K.) 39/, 1−7 2009 (学術雑誌)

○Identification of a WT1 protein-derived peptide, WT1187 as an HLA-A*0206-restricted, WT1-specific CTL epitope. 
 Microbiology and Immunology (Li Z., Oka Y., Tsuboi A., Fujiki F., Harada Y., Nakajima H., Masuda T., Fukuda Y., Kawakatsu M., Morimoto S., Katagiri T., Tatsumi N., Hosen N., Shirakata T., Nishida S., Kawakami Y., Udaka K., Kawase I., Oji Y., and Sugiyama H. ) 52(11)/, 551-558 2008 (学術雑誌)

○Biochemical visualization of cell surface molecular clustering in living cells.
 Proc Natl Acad Sci USA (Kotani N., Gu J., Isaji T., Udaka K., Taniguchi N. and Honke K. ) 105(21)/, 7405-7409 2008 (学術雑誌)

○Human leukocyte antigen-G, a ligand for the natural killer receptor KIR2DL4, is expressed by eutopic endometrium only in the menstrual phase. 
 Fertil Steril  [Epub ahead of print] (Kawashima M., Maeda N., Adachi Y., Takeuchi T., Yamamoto Y., Izumiya C., Hayashi K., Furihata M., Udaka K. and Fukaya T. ) /, 2008 (学術雑誌)

○Wilms’ tumor 1 gene expression is increased in hepatocellular carcinoma and associated with poor prognosis.
 Eur J Cancer (Sera T., Hiasa Y., Mashiba T., Tokumoto Y., Hirooka M., Konishi I., Matsuura B., Michitaka K., Udaka K. and Onji M. ) 44(4)/, 600-608 2008 (学術雑誌)

○Wilms’ tumor gene WT1 peptide-based immunotherapy induced a minimal response in a patient with advanced therapy-resistant multiple myeloma. 
 Int J Hematol (Tsuboi A., Oka Y., Nakajima H., ukuda Y., Elisseeva O.A., Yoshihara S., Hosen N., Ogata A., Kito K., Fujiki F., Nishida S., Shirakata T., Ohno S., Yasukawa M., Oji Y., Kawakami M., Morita S., Sakamoto J., Udaka K., Kawase I. and Sugiyama H. ) 86(5)/, 414-417 2007 (学術雑誌)

○Potent CTL induction by a whole cell pertussis vaccine in anti-tumor peptide immunotherapy.
 Microbiology and Immunology (Yano A., Komatsu T. Ishibashi M. and Udaka K. ) 51(7)/, 685-699 2007 (学術雑誌)

○Identification of CTL epitopes in hepatitis C virus by a genome-wide computational acanning and a rational design of peptide vaccine.
 Microbiology and Immunology (Iiyama T., Takeda S., Udaka K., Takeuchi T., Adachi Y.C., Shuin T., Ohtsuki Y., Oka Y., Tsuboi A., Nakatsuka S., Elisseeva O.A., Oji Y., Nakajima H., Kawakami M., Nishida S., Shirakata T., and Sugiyama H. ) 51(5)/, 59-530 2007 (学術雑誌)

○Structure of the cadherin-rerated neuronal receptor/protocadherin-α first cadherin domain reveals diversity across cadherin families.
 Journal of Immunotherapy (Fujiki F., Oka Y., Tsuboi A., Kawakami M., Kawakatsu M., Nakajima H., Elisseeva O.A., Harada Y., Ito K., Li Z., Tatsumi N., Sakaguchi N., Fujioka T., Masuda T., Yasukawa M., Udaka K., Kawase I., Oji Y. and Sugiyama H. ) 30(3)/, 282-293 2007 (学術雑誌)

○Improving MHC binding peptide prediction by incorporating binding data of auxiliary MHC molecules.
 Immunogenetics (Mashiba T., Udaka K., Hirachi Y., Miyakawa T., Satta Y., Osada T., Kataoka S., Kohara M. and Onji M.) 59/, 197-209 2007 (学術雑誌)

○Fyn regulated eosinophil infiltration into the conjunctiva by downregulating the Th2 response.
 J. Biol. Chem (Morishita H., Umitsu M., Murata Y., Shibata N., Udaka K., Higuchi Y., Akutsu H., Yamaguchi T. and Ikegami T. ) 281(44)/, 33650-33663 2006 (学術雑誌)

○Mice lacking the IFN-gamma receptor or fyn develop severe experimental autoimmune uveoretinitis characterized by different immune responses.
 Jpn. J. Clin. Oncol. (Morita S., Oka Y., Tsuboi A., Kawakami M., Maruno M., Izumoto S., Osaki T., Taguchi T., Ueda T., Myoui A., Nishida S., Shirakawa T., Ohno S., Oji Y., Aozasa K., Hatazawa J., Udaka K., Yoshikawa H., Yoshimine T., Noguchi S., Kawase I., Nakatsuka S., Sugiyama H. and Sakamoto J. ) 36(4) /, 231-236 2006 (学術雑誌)

○1H, 13C and 15N resonance assignments of the first cadherin domain of Cadherin-related neuronal receptor CNR)/ protocadherin alpha.
 Bioinfomatics (Zhu S., Udaka K., Sidney J., Sette A., Aoki-Kinoshita K.F. and Mamitsuka H.) 22(13)/, 1648-1655 2006 (学術雑誌)

○Induction of WT1(Wilms’ tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression.
 Int. J. Hematol. (Li Z., Oka Y., Tsuboi A., Masuda T., Tatsumi N., Kawakami M., Fujioka T., Sakaguchi N., Nakajima H., Fujiki F., Udaka K., Oji Y., Kawase I. And Sugiyama H.) 82/, 458-459 2005 (学術雑誌)

○T1 peptide-based immunotherapy for patients with lung cancer: Report of two case.
 Grafes Arch. Clin. Exp. Ophthalmol. (A. Fukushima, T. Yamaguchi, A. Ozaki, T. Taniguchi, K. Udaka and H. Ueno ) 243/, 1043-1049 2005 (学術雑誌)

○Wilms Tumor Gene Peptide-Based Immunotherapy for Patients with Overt Leukemia from Myelodysplastic Syndrome (MDS) or MDA with Myelofibrosis.
 Immunogenetics (A. Fukushima, T. Yamaguchi, W. Ishida, K. Fukata, K. Udaka and H. Ueno) 57(5)/, 337-343 2005 (学術雑誌)

○Actin-rich spherical extrusion induced in Okadaic acid-treated K562 cells by crosslinking of membrane microdomains.
 J. Biomol. NMR. (Umitsu M., Morishita H., Murata Y., Udaka K., Akutsu H., Yagi T. and Ikegami Y. ) 31(4)/, 365-366 2005 (学術雑誌)

○Enhanced induction of human WT1-specific cytotoxic T lymphocytes with a 9-mer WT1 peptide modified at HLA-A*2402-binding residues.
 Proc. Natl. Acad. Sci USA ( Y. Oka, A. Tsuboi, T. Taguchi, T. Osaki, T. kyo, H. Nakajima, O.A.Elisseeva, Y. Oji, M. Kawakami, K. Ikegami, N. Hosen, S. Yoshihara, F. Wu, F. Fujiki, M. Murakami, T. Masuda, S. Nishida, T. Shirakawa, S. Nakatsuka, A. Sasaki, K. Udaka, H. Dohy, K. Aozasa, S. Noguchi, I. Kawase and H. Sugiyama ) 21/, 13885-13890 2004 (学術雑誌)

○Empirical evaluation of a dynamic experiment design method for prediction of MHC class I-binding peptides.
 Microbiol.Immunol ( A. Tsuboi, Y. Oka, T. Osaki, T. Kumagai, I. Tachibana, S. Hayashi, M. Murakami, H. Nakajima, O.A. Elisseeva, W. Fei, T. Masuda, M. Yasukawa, Y. Oji, M. Kawakami, N. Hosen, K. Ikegame, S. Yoshihara, K. Udaka, S.-I. Nakatsuka, K. Aozasa, I. Kawase and H. Sugiyama. ) 48/, 175-184 2004 (学術雑誌)

○Humoral immune responses against Wilms’ tumor gene WT1 product in patients with hematopoietic malignancies.
 Int. J. Hematology ( Y. Oka, A. Tsuboi, M. Murakami, M. Hirai, N. Tominaga, H. Nakajima, O.A. Elisseeva, T. Yasukawa, H. Ogawa, I. Kawase and H. Sugiyama ) 78/, 56-61 2003 (学術雑誌)

○NMR study on the interaction between MHC class I protein and its antigen peptide.
 J. Histochem. Cytochem. (T. Baba, K. Udaka, N. Terada, H. Ueda, Y. Fujii, S. Ohno and S.B. Sato ) 51/, 1-8 2003 (学術雑誌)

○An automated prediction of MHC class I-binding peptides based on positional scanning with peptide libraries.
 Cancer Immunol. Immunother. (A. Tsuboi, Y. Oka, K. Udaka, M. Murakami, T. Masuda, A. Nakano, H. Nakajima, M. Yasukawa, A. Hiraki, Y. Oji, M. Kawakami, N. Hosen, T. Fujioka, F. Wu, Y. Taguchi, S. Nishida, M. Asada, H. Ogawa, I. Kawase and H. Sugiyama ) 51(11-12)/, 614-620 2002 (学術雑誌)

○Cytotoxic T-lymphocyte responses elicited to Wilms’ tumor gene WT1 product by DNA vaccination.
 J Immunol (Keiko Udaka, Hiroshi Mamitsuka, Yukinobu Nakaseko and Naoki Abe.) 169/, 5744-5753 2002 (学術雑誌)

○Cancer immunotherapy targeting Wilms
 Blood ( O. A Elisseeva, Y. Oka, A. Tsuboi K. Ogata, F. Wu, E.H. Kim, T. Soma H. Tamaki, M. Kawakami, Y. Oji, N. Hosen, T. Kubota M. Nakagawa, T. Yamagami, A. Hiraoka, M. Tsukaguchi, K. Udaka, H. Ogawa, T. Kishimoto, T. Nomura and H. Sugiyama ,) 99/, 3272-3279 2002 (学術雑誌)

○Human cytotoxic T cell response specific for peptides of wild-type Wilms’ tumor gene (WT1) product.
 Biochem Biophys Res Commun (Masatoshi Nakagawa, Kaori Chiba-Kamoshida, Keiko Udaka and Hiroshi Nakanishi. ) 278/, 609-613 2000 (学術雑誌)

○Efficient induction of peptide specific cytotoxic T lymphocytes by LPS activated spleen cells.
 Immunogenetics, (K. Udaka, K.-H. Wiesmuller, S. Kienle, G. Jung, H. Tamamura, H. Yamagishi, K. Okumura, P. Walden, T. Suto and T. Kawasaki. ) 51(10)/, 816-828 2000 (学術雑誌)

■ 研究業績(著書)

■ 研究業績(口頭・ポスター)

■ 研究業績(特許)

■ 研究業績(その他の活動)


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