■ 氏名
降幡 睦夫 (フリハタ ムツオ)
FURIHATA Mutsuo

■ 所属部局/職名
Research and Education Faculty, Medical Sciences Cluster, Cooperation Medicine Unit/Professor
教育研究部 医療学系 連携医学部門/教授

■ 学部・学科・コース等
Medical School, Medical Course, Department of Pathology
医学部 医学科 病理学

■ 連絡先
住 所
電 話088-880-2334
F A X
E-Mailfuriham●kochi-u.ac.jp    (送信の際は“●”を半角の“@”に変更して送信してください。)
U R L

■ 出身大学院・研究科等

■ 出身学校・専攻等
高知医科大学 ( 医学科) 1989 (卒業)

■ 取得学位
医学博士 (論文) 高知医科大学

■ 研究職歴

■ 委員歴・役員歴

■ 受賞学術賞

■ 所属学会
日本病理学会
 ( 国内)
日本癌学会
 ( 国内)
日本臨床細胞学会
 ( 国内)

■ 専門分野
尿路・前立腺腫瘍病理学

■ 主な研究テーマ・活動

■ 研究についてのPR

■ 社会人・生徒を対象として可能な講演・授業(例えば講演題目)
尿路・前立腺悪性腫瘍の病態病理

■ 研究業績(論文・解説)
Terrestrosin D, a Steroidal Saponin from Tribulus terrestris L., Inhibits Growth and Angiogenesis of Human Prostate Cancer in vitro and in vivo.
 Pathobiology. (Wei S, Fukuhara H, Chen G, Kawada C, Kurabayashi A, Furihata M, Inoue K, Shuin T) 81/3, 123-132 2014 (学術雑誌)

RUVBL1 directly binds actin filaments and induces formation of cell protrusions to promote pancreatic cancer cell invasion.
 Int J Oncol. (Taniuchi K, Furihata M, Iwasaki S, Tanaka K, Shimizu T, Saito M, Saibara T) 44/6, 1945-1954 2014 (学術雑誌)

Antimuscle atrophy effect of nicotine targets muscle satellite cells partly through an α7 nicotinic receptor in a murine hindlimb ischemia model.
 Transl Res. (Kakinuma Y, Noguchi T, Okazaki K, Oikawa S, Iketani M, Kurabayashi M, Furihata M, Sato T) 164/1, 32-45 2014 (学術雑誌)

IGF2BP3-mediated translation in cell protrusions promotes cell invasiveness and metastasis of pancreatic cancer.
 Oncotarget. (Taniuchi K, Furihata M, Hanazaki K, Saito M, Saibara T) 5/16, 6832-6845 2014 (学術雑誌)

KIF20A-mediated RNA granule transport system promotes the invasiveness of pancreatic cancer cells.
 Neoplasia. (Taniuchi K, Furihata M, Saibara T) 16/12, 1082-1093 2014 (学術雑誌)

CD34(+) /CD38(-) acute myelogenous leukemia cells aberrantly express CD82 which regulates adhesion and survival of leukemia stem cells.
 Int J Cancer. (Nishioka C, Ikezoe T, Furihata M, Yang J, Serada S, Naka T, Nobumoto A, Kataoka S, Tsuda M, Udaka K, Yokoyama A) 132/9, 2006-2019 2013 (学術雑誌)

Photodynamic therapy involves an antiangiogenic mechanism and is enhanced by ferrochelatase inhibitor in urothelial carcinoma.
 Cancer Sci. (Inoue K, Fukuhara H, Kurabayashi A, Furihata M, Tsuda M, Nagakawa K, Fujita H, Utsumi K, Shuin T) 104/6, 765-772 2013 (学術雑誌)

Plasma low-molecular-weight proteome profiling identified neuropeptide-y as a prostate cancer biomarker polypeptide.
 J Proteome Res. (Ueda K, Tatsuguchi A, Saichi N, Toyama A, Tamura K, Furihata M, Takata R, Akamatsu S, Igarashi M, Nakayama M, Sato TA, Ogawa O, Fujioka T, Shuin T, Nakamura Y, Nakagawa H) 12/10, 4497-4506 2013 (学術雑誌)

Application of 5-aminolevulinic acid-mediated photodynamic diagnosis to robot-assisted laparoscopic radical prostatectomy.
 Urology. (Inoue K, Ashida S, Fukuhara H, Iiyama T, Miyamura M, Kurabayashi A, Furihata M, Shuin T :) 82/5, 1175-1178 2013 (学術雑誌)

The inhibition of ferrochelatase enhances 5-aminolevulinic acid-based photodynamic action for prostate cancer.
 Photodiagnosis Photodyn Ther. (Fukuhara H, Inoue K, Kurabayashi A, Furihata M, Fujita H, Utsumi K, Sasaki J, Shuin T) 10/4, 399-409 2013 (学術雑誌)

Augmented autocrine bone morphogenic protein (BMP) 7 signaling increases the metastatic potential of mouse breast cancer cells.
 Clin Exp Metastas. (Sakai H, Furihata M, Matsuda C, Takahashi M, Miyazaki H, Konakahara T, Imamura T, Okada T) 29/4, 327-338 2012 (学術雑誌)

IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility.
 Hum Mol Genet. (Ha Nguyen H, Takata R, Akamatsu S, Shigemizu D, Tsunoda T, Furihata M, Takahashi A, Kubo M, Kamatani N, Ogawa O, Fujioka T, Nakamura Y, Nakagawa H) 21/9, 2076-2085 2012 (学術雑誌)

Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese.
 Nat Genet. (Akamatsu S, Takata R, Haiman CA, Takahashi A, Inoue T, Kubo M, Furihata M, Kamatani N, Inazawa J, Chen GK, Le Marchand L, Kolonel LN, Katoh T, Yamano Y, Yamakado M, Takahashi H, Yamada H, Egawa S, Fujioka T, Henderson BE, Habuchi T, Ogawa O, Nakamura Y, Nakagawa H) 44/4, 426-429 2012 (学術雑誌)

Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling.
 Arterioscl Throm Vas. (Ikezoe T, Yang J, Nishioka C, Honda G, Furihata M, Yokoyama A) 32/, 2259-2270 2012 (学術雑誌)

Conditional VHL gene deletion activates a local NO-VEGF axis in a balanced manner reinforcing resistance to endothelium-targeted glomerulonephropathy.
 Nephrol Dial Transplant. (Morita T, Kakinuma Y, Kurabayashi A, Fujieda M, Sato T, Shuin T, Furihata M, Wakiguchi H) 26/, 4023-4031 2011 (学術雑誌)

The ubiquitin-like molecule interferon-stimulated gene 15 is overexpressed in human prostate cancer. 
 Oncol Rep. (Satake H, Tamura K, Furihata M, Anchi T, Sakoda H, Kawada C, Iiyama T, Ashida S, Shuin T) 23/1, 11-16 2010 (学術雑誌)

5alphaDH-DOC(5alpha-dihydro-deoxycorticosterone) activates androgen receptor in castration-resistant prostate cancer.
 Cancer Sci. (Uemura M, Honma S, Chung S, Takata R, Furihata M, Nishimura K, Nonomura N, Nasu Y, Miki T, Shuin T, Fujioka T, Okuyama A, Nakamura Y, Nakagawa H) 101/8, 1897-1904 2010 (学術雑誌)

AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells.
 Mol Cancer Ther. (Yang J, Ikezoe T, Nishioka C, Furihata M, Yokoyama A) 9/12, 3386-3395 2010 (学術雑誌)

Analysis of Aurora B kinase in non-Hodgkin lymphoma.
 Laboratory Investigation. (Ikezoe T, Takeuchi T, Yang J, Adachi Y, Nishioka C, Furihata M, Koeffler HP, Yokoyama A ) 89/12, 1364-1373 2009 (学術雑誌)

Chemokine CCL2/MCP-1 negatively regulates metastasis in a highly bone marrow-metastatic mouse breast cancer model.
 Clin Exp Metastasis. (Takahashi M, Miyazaki H, Furihata M, Sakai H, Konakahara T, Watanabe M, Okada T) 26/7, 817-828 2009 (学術雑誌)

Zeb1-mediated T-cadherin repression increases the invasive potential of gallbladder cancer.
 Adachi Y, Takeuchi T, Nagayama T, Ohtsuki Y, Furihata M (FEBS Lett. ) 583/2, 430-436 2009 (学術雑誌)

Overexpressing PKIB in prostate cancer promotes its aggressiveness by linking between PKA and Akt pathways.
 Oncogene. (Chung S, Furihata M, Tamura K, Uemura M, Daigo Y, Nasu Y, Miki T, Shuin T, Fujioka T, Nakamura Y, Nakagawa H) 28/32, 2849-2859 2009 (学術雑誌)

Stanniocalcin 2 overexpression in castration - resistant prostate cancer and aggressive prostate cancer.
 Cancer Sci. (Tamura K, Furihata M, Chung SY, Uemura M, Yoshioka H, Iiyama T, Ashida S, Nasu Y, Fujioka T, Shuin T, Nakamura Y, Nakagawa H) 100/5, 914-919 2009 (学術雑誌)

Overexpression of the potential kinase serine/ threonine/tyrosine kinase 1 (STYK 1) in castration-resistant prostate cancer.
 Cancer Sci. (Chung S, Tamura K, Furihata M, Uemura M, Daigo Y, Nasu Y, Miki T, Shuin T, Fujioka T, Nakamura Y, Nakagawa H) 100/11, 2109-2114 2009 (学術雑誌)

Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism.
 Cancer Res. (Tamura K, Makino A, Hullin-Matsuda F, Kobayashi T, Furihata M, Chung S, Ashida S, Miki T, Fujioka T, Shuin T, Nakamura Y, Nakagawa H) 69/20, 8133-8140 2009 (学術雑誌)

■ 研究業績(著書)

■ 研究業績(口頭・ポスター)

■ 研究業績(特許)

■ 研究業績(その他の活動)


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