■ 氏名
八幡 俊男 (ヤワタ トシオ)
YAWATA Toshio

■ 所属部局/職名
Research and Education Faculty, Medical Sciences Cluster, Clinical Medicine Unit/Assistant Professor
教育研究部 医療学系 臨床医学部門/助教

■ 学部・学科・コース等
Medical School, Medical Course, Department of Neurosurgery
医学部 医学科 脳神経外科学

■ 連絡先
住 所
電 話088-880-2397
F A X
E-Mailyawatat●kochi-u.ac.jp    (送信の際は“●”を半角の“@”に変更して送信してください。)
U R L

■ 出身大学院・研究科等
島根大学 修士(理学研究科 生物系専攻) 1994 (修了)
鳥取大学 博士(医学研究科 生物系専攻) 1998 (修了)

■ 出身学校・専攻等
島根大学 (理学部 生物学科) 1991 (卒業)

■ 取得学位
医学博士 (課程) 鳥取大学 人類遺伝学

■ 研究職歴
1998-1999 鳥取大学中核的研究機関研究員
1999-2000 米国環境健康科学研究所研究員
2000-2004 米国がん研究所研究員
2004-  高知大学医学部助手

■ 委員歴・役員歴

■ 受賞学術賞

■ 所属学会
日本癌学会
 ( )
日本脳腫瘍学会
 ( 国内)
日本遺伝子治療学会
 ( )
分子脳神経外科学会
 ( )
日本再生医療学会
 ( )

■ 専門分野
細胞、分子生物学

■ 主な研究テーマ・活動
がん幹細胞を標的とした治療法の開発
がん精巣抗原遺伝子の発現調節機構の解析
細胞老化機構の解明

■ 研究についてのPR

■ 社会人・生徒を対象として可能な講演・授業(例えば講演題目)

■ 研究業績(論文・解説)
Brain opioid and nociceptin receptors are involved in regulation of bombesin-induced activation of central sympatho-adrenomedullary outflow in the rat.
 Mol Cell Biochem (Yawata T, Higashi Y, Shimizu T, Shimizu S, Nakamura K, Taniuchi K, Ueba T, Saito M) /, in press (学術雑誌)

Possible inhibitory role of endogenous 2-arachidonoylglycerol as an endocannabinoid in (±)-epibatidine-induced activation of central adrenomedullary outflow in the rat.
 Neuropharmacol (Shimizu T, Tanaka K, Shimizu S, Higashi Y, Yawata T, Nakamura K, Taniuchi K, Ueba T, Yuri K, Saito M) 95/, 278-289 2015 (学術雑誌)

Prevalence of human cytomegalovirus, polyomaviruses, and oncogenic viruses in glioblastoma among Japanese subjects.
 Infect Agent Cancer (Hashida Y, Taniguchi A, Yawata T, Hosokawa S, Murakami M, Hiroi M, Ueba T, Daibata M) 10/, 3 2015 (学術雑誌)

Elevated cell invasion in a tumor sphere culture of RSV-M mouse glioma cells.
 Neurol Med Chir (Tokyo) (Nonaka M, Yawata T, Takemura M, Higashi Y, Nakai E, Shimizu K, Ueba T) 55/, 60-70 2015 (学術雑誌)

Angiotensin II acting on brain AT1 receptors induces adrenaline secretion and pressor responses in the rat.
 Sci Rep (Nakamura K, Shimizu T, Yanagita T, Nemoto T, Taniuchi K, Shimizu S, Dimitriadis F, Yawata T, Higashi Y, Ueba T, Saito M) 4/, 7248 2014 (学術雑誌)

Suppression of oxidative stress and 5-lipoxygenase activation by edaravone improves depressive-like behavior after concussion.
 J Neurotrauma (Higashi Y, Hoshijima M, Yawata T, Nobumoto A, Tsuda M, Shimizu T, Saito M, Ueba T) 31/, 1689-1699 2014 (学術雑誌)

Gene therapy strategies for treating brain tumors: Retroviruses are still good candidates for therapeutic vectors.
 Open J Genet. (Yawata T, Shimizu K) 3/, 12-18 2013 (学術雑誌)

Possible involvement of brain prostaglandin E2 and prostanoid EP3 receptors in prostaglandin E2 glycerol ester-induced activation of central sympathetic outflow in the rat.
 Neuropharmacology (Shimizu T, Tanaka K, Nakamura K, Taniuchi K, Yawata T, Higashi Y, Ueba T, Dimitriadis F, Shimizu S, Yokotani K, Saito M) 82/, 19-27 2014 (学術雑誌)

Efficient siRNA delivery and tumor accumulation mediated by ionically cross-linked folic acid-poly(ethylene glycol)-chitosan oligosaccharide lactate nanoparticles: For the potential targeted ovarian cancer gene therapy.
 E. J. Pharm. Sci (Li SC, Yawata T, Honke K) 52/, 48-61 2013 (学術雑誌)

Regulatory effects of Spirulina complex polysaccharides on growth of murine RSV-M gliomas cells through toll-like receptor 4.
 Microbiol Immunol (Kawanishi Y, Tominaga A, Okuyama H, Fukuoka S, Taguchi T, Kusumoto Y, Yawata T, Fujimoto Y, Ono S, Shimizu K) 57/, 63-73 2013 (学術雑誌)

Attenuation of axonal injury and oxidative stress by edaravone protects against cognitive impairments after traumatic brain injury.
 Brain Res (Ohta M, Higashi Y, Yawata T, Kitahara M, Nobumoto A, Ishida R, Tsuda M, Fujimoto Y, Shimizu K) 1490/, 184-192 2013 (学術雑誌)

Identification and functional characterization of glioma-specific promoters and their application in suicide gene therapy.
 J Neuro-oncology (Yawata T, Maeda Y, Okiku M, Ishida E, Ikenaka K, Shimizu K:) 104/2, 497-507 2011 (学術雑誌)

Anti-invasive and antiangiogenic effects of MMI-166 on malignant glioma cells.
 BMC Cancer (Nakabayashi H, Yawata T, Shimizu K) 10/, 339 2010 (学術雑誌)

Enhanced expression of cancer testis antigen genes in glioma stem cells.
 Molecular Carcinogenesis (Yawata T, Nakai E, Park KC, Chihara T, Kumasawa A, Toyonaga S, Masahira N, Nakabayashi H, Kaji T, Shimizu K) 49/, 532-544 2010 (学術雑誌)

Enhanced MDR1 expression and chemoresistance of cancer stem cells derived from glioblastoma.
 Cancer Investigation (Nakai E, Park K, Yawata T, Chihara T, Kumazawa A, Nakabayashi H, Shimizu K) 27/9, 901-908 2009 (学術雑誌)

Development of gene therapy for malignant gliomas using high-titer retroviral vectors.
 Trends in Cancer Research (Yawata T, Ikenaka K, Shimizu K) 2/, 33-46 2006 (学術雑誌)

Interleukin-6 induces expression of MHC class I molecules on microglia.
 Neurotrauma Research (Kaji T, Yawata T, Masahira N, Nakai E, Chihara T, Park KC, Shimizu K) 18/, 1-3 2006 (学術雑誌)

Identification of a ? 600-kb region on human chromosome 1q42.3 that induces cellular senescence
 Oncogene (Yawata T, Kamino H, Kugoh H, Katoh M, Nomura N, Oishi M, Horikawa I, Barrett JC, Oshimura M) 22/, 281-290 2003 (学術雑誌)

Cellular Senescence Mechanisms Independent of Telomere Shortening and Telomerase: Other Barriers to Cell Immortalization and Carcinogenesis
 Journal of Anti-Aging Medicine (IZUMI HORIKAWA, TOSHIO YAWATA, and J. CARL BARRETT) 3/4, 373-382 2000 (学術雑誌)

Production of a STF (subchromosomal transferable fragment) panel for gene mapping by microcell-mediated chromosome transfer:Mapping of a cellular senescence gene on human chromosome 1
 米子医学雑誌 (八幡 俊男) 49/, 147-160 1998 (学術雑誌)

Cosmid and transcribed sequences from chromosome 11q23
 Japanese Journal of Human Genetics (Katoh M, Nakagawa Y, Yawata T, Kumano S, Kobayashi E, Kurimasa A, Kugoh H, Oshimura M) 40/, 307-31 1995 (学術雑誌)

Study on calcium-binding protein from Escherichia coli L-form NC7
 Memoirs of Faculty of Science, Shimane Univ (Yawata T. Oshima A, Onoda T) 29/, 37-43 1995 (大学・研究所等紀要)

■ 研究業績(著書)
八幡 俊男,清水 惠司: 腫瘍内在幹細胞. 寺本 明(編)NS NOW No.5 グリオーマ‐その最新知見,pp40-45(2009)
 出版社:メジカルビュー社

八幡 俊男, 熊野 聡, 押村 光雄:単一染色体導入法と応用. 木村彰方 編 医学・薬学研究者のための バイオテクノロジー概論 (2000)
 出版社:医薬ジャーナル社

■ 研究業績(口頭・ポスター)

■ 研究業績(特許)
「腫瘍特異的プロモーターおよびその用途」    
 特許5494916号

■ 研究業績(その他の活動)


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