■ 氏名
安川 孝史 (ヤスカワ タカシ)
YASUKAWA Takashi

■ 所属部局/職名
Research and Education Faculty, Medical Sciences Cluster, Basic Medicine Unit/Assistant Professor
教育研究部 医療学系 基礎医学部門/助教

■ 学部・学科・コース等
Medical School, Medical Course, Department of Functional Genomics
医学部 医学科 遺伝子機能解析学

■ 連絡先
住 所
電 話880-2579
F A X
E-Mailtyasu●kochi-u.ac.jp    (送信の際は“●”を半角の“@”に変更して送信してください。)
U R L

■ 卒業大学及び大学院等
筑波大学大学院医学研究科

■ 学位(種類)
博士(医学)

■ 所属学会
日本分子生物学会

■ 専門分野
分子生物学・生化学

■ 主な研究テーマ・活動
遺伝子発現制御機構・細胞増殖制御機構の解析

■ 研究についてのPR

■ 社会人・生徒を対象として可能な講演・授業(例えば講演題目)

■ 研究業績
(*first author equivalent):
Yasukawa T, Kamura T, Kitajima S, Conaway RC, Conaway JW, Aso T.
Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1.
EMBO J. 2008; 27: 3256-3266

Miyata K, Yasukawa T*, Fukuda M, Takeuchi T, Yamazaki K, Sakumi K, Tamamori-Adachi M, Ohnishi Y, Ohtsuki Y, Nakabeppu Y, Kitajima S, Onishi S,and Aso T. Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A.
Cell Death and Diff. 2007; 14: 716-726

Yasukawa T, Sugimura K, Fukuda M, Yamazaki K, Kitajima S, Okumura K and Aso T.
Functional characterization of a mammalian transcription factor, Elongin A.
Biochem. Biophys. Res. Commun. 2007; 352(1): 237-243

Sugita H, Fujimoto M, Yasukawa T, Shimizu N, Sugita M, Yasuhara S, Martyn JA, Kaneki M.
Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells.
J. Biol. Chem. 2005; 280: 14203-14211

Sugita H, Kaneki M, Sugita M, Yasukawa T, Yasuhara S, Martyn JA.
Burn injury impairs insulin-stimulated Akt/PKB activation in skeletal muscle.
Am J Physiol Endocrinol Metab. 2005; 288: E585-591

Yasukawa T, Tokunaga E, Ota H, Sugita H, Martyn JA, Kaneki M. S-Nitrosylation-dependent inactivation of Akt/PKB in insulin resistance.
J. Biol. Chem. 2005; 280: 7511-7518

Yasukawa T, Kaneki M, Yasuhara S, Lee SL, Martyn JA. Steroidal nondepolarizing muscle relaxants do not simulate the effects of glucocorticoids on glucocorticoid receptor-mediated transcription in cultured skeletal muscle cells.
Anesthesiology. 2004; 100: 1615-1619

Matsuda S, Yasukawa T, Homma Y, Shao Z, Ito Y, Niikura T, Hiraki T, Hirai S, Ohno S, Kita Y, Kawasumi M, Kouyama K, Yamamoto T, Kyriakis JM, Nishimoto I. c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. J. Neurosci. 2001; 21: 6597-6607

Hashimoto Y, Niikura T, Tajima H, Yasukawa T, Sudo H, Ito Y, Kita Y, Kawasumi M, Kouyama K, Doyu M, Sobue G, Koide T, Tsuji S, Lang J, Kurokawa K, Nishimoto I. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Ab.
Proc. Natl. Acad. Sci. U S A 2001; 98: 6336-6341

Sudo H, Hashimoto Y, Niikura T, Shao Z, Yasukawa T, Ito Y, Yamada M, Hata M, Hiraki T, Kawasumi M, Kouyama K, and Nishimoto I. Secreted Ab does not mediate neurotoxicity by antibody-stimulated amyloid precursor protein.
Biochem. Biophys. Res. Commun. 2001; 282: 548-556

Niikura T, Hashimoto Y, Okamoto T, Abe Y, Yasukawa T, Kawasumi M, Hiraki T, Kita Y, Terashita K, Kouyama K and Nishimoto I. IGF-I protects cells from apoptosis by Alzheimer's V642I mutant APP through IGF-I receptor in an IGF binding protein-sensitive manner.
J. Neurosci. 2001; 21: 1902-1910

Kokura K, Kaul SC, Wadhwa R, Nomura T, Khan MM, Shinagawa T, Yasukawa T, Colmanares C, Ishii S. The Ski protein family is required for MeCP2-mediated transcriptional repression.
J. Biol. Chem. 2001; 276: 34115-34121

Sudo H, Jiang H, Yasukawa T*, Hashimoto Y, Niikura T, Kawasumi M, Matsuda S, Takeuchi Y, Aiso S, Matsuoka M, Murayama Y and Nishimoto I. Antibody regulated neurotoxic function of cell surface b-amyloid precursor protein.
Mol. Cell. Neurosci. 2000; 16: 708-723

Kittaka A, Kuze T, Amano M, Tanaka H, Miyasaka T, Hirose K, Yoshida T, Sarai A, Yasukawa T and Ishii S. Introduction of 6-formylcytidine into a Myb binding sequence.
Nucleosides Nucleotides. 1999; 18: 2769-2783

Tokitou F, Nomura T, Khan MM, Kanl SC, Wadhwa K, Yasukawa T, Kohno I and Ishii S. Viral ski inhibits retinoblastoma protein(Rb)-mediated transcriptional repression in a dominant negative fashon.
J. Biol. Chem. 1999; 274: 4485-4488

Kanei-Ishii C, Nomura T, Ogata K, Sarai A, Yasukawa T, Tashiro S, Takahashi T, Tanaka Y, Ishii S. Structure and function of the proteins encoded by the myb gene family.
Curr. Top. Microbiol. Immunol. 1996; 211: 89-98

Dai P, Akimaru H, Tanaka T, Hou D-X, Yasukawa T, Kanei-Ishi C, Takahashi T and Ishii S. CBP as a transcriptional coactivator of c-Myb.
Genes & Dev. 1996; 10: 528-540
Mizuguchi G, Kanei-Ishii C,Takahashi T, Yasukawa T, Nagase T, Horikoshi M, Yamamoto T and Ishii S. c-Myb Repression of c-erbB-2 Transcription by Direct Binding to the c-erbB-2 Promoter.
J. Biol. Chem. 1995; 270: 9384-9389

Yasukawa T, Kanei-Ishii C, Maekawa T, Fujimoto J, Yamamoto T and Ishii S. Increase of Solubility of Foreign proteins in Eschericha coli by coproduction of the bacterial thioredoxin.
J. Biol. Chem. 1995; 271: 25328-25331

Kanei-Ishii C, Yasukawa T, Morimoto RI and Ishii S. c-Myb-induced trans activation mediated by heat shock elements without sequence-specific DNA binding of c-Myb.
J. Biol. Chem. 1994; 269: 15768-15775

Sarai A, Uedaira H, Morii H, Yasukawa T, Ogata K, Nishimura Y and Ishii S. Thermal stability of the DNA-binding domain of the Myb oncoprotein.
Biochemistry 1993; 39: 7759-7764

Tanikawa J, Yasukawa T, Enari M, Ogata K, Nishimura Y, Ishii S and Sarai A. Recognition of specific DNA sequences by the c-myb protooncogene product : Role of three repeat units in the DNA-binding domain.
Proc. Natl. Acad. Sci. USA 1993; 90: 9320-9324



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