■ 氏名
花崎 和弘 (ハナザキ カズヒロ)
HANAZAKI Kazuhiro

■ 所属部局/職名
Research and Education Faculty, Medical Sciences Cluster, Clinical Medicine Unit/Professor
教育研究部 医療学系 臨床医学部門/教授

■ 学部・学科・コース等
Medical School, Medical Course, Department of Surgery (Hepato-Gastroenterological Surgery)
医学部 医学科 外科学(消化器外科学)

■ 連絡先
住 所
電 話088-880-2370
F A X
E-Mailhanazaki●kochi-u.ac.jp    (送信の際は“●”を半角の“@”に変更して送信してください。)
U R L

■ 卒業大学及び大学院等
新潟大学医学部医学科

■ 学位(種類)
医学博士

■ 所属学会
外科学会・消化器外科学会・肝胆膵外科学会・臨床外科学会・消化器病学会・肝蔵学会・癌治療学会・人工臓器学会など

■ 専門分野
肝蔵・胆道・膵臓外科

■ 主な研究テーマ・活動
肝臓・胆道・膵臓癌外科治療成績の向上
新しい人工膵臓の開発、肝再生医療学
肝糖代謝異常のメカニズムの解明とその対策
安全な膵臓・肝臓切離法の開発

■ 研究についてのPR
日常診療で発生した疑問点や問題点をテーマにした研究課題に取り組んでいきたいと考えています。したがって日常診療を支えるための基礎的研究を重視し、将来的には臨床の場にその成果を必ずfeed backできるような研究(トランスレーショナルリサーチ)を目指しています。

■ 社会人・生徒を対象として可能な講演・授業(例えば講演題目)
外科医の魅力と外科医療の未来
肝蔵・胆道・膵臓外科治療の最前線
消化器癌の手術が必要になった場合はどうしたら良いのか?
人工膵臓の現況と将来展望

■ 研究業績
1.Hanazaki K, Maeda H,Okabayashi T:Tight perioperative glycemic control using an artificial endocrine pancreas Surg Today 2010; (in press)

2.Hanazaki K, Okabayashi T, Maeda H:Tight Glycemic Control Using an Artifical Pancreas to Control Perioperative Hyperglycemia Decreases Surgical Site Infection in Pancreatectomized or Hepatectomized Patients. Ann Surg 2009;250: 351-352

3.Hanazaki K, Maeda H,Okabayashi T: Relationship between perioperative glycemic control and postoperative infections. World J Gastroenterol 2009; 15:4122-4125

4.Okabayashi, Nishimori I, Yamashita K, Sugimoto T, Namikawa T, Maeda H, Yatabe T, Hanazaki K:Preoperative oral supplementation with carbohydrate and branched-chain amino acid-enriched nutrient improves insulin resistance in patients undergoing a hepatectomy: a randomized clinical trial using an artificial pancreas.Amino Acids 2009; [Epub ahead of print]

5.Maeda H, Okabayashi T, Nishimori I, Yamashita K. Sugimoto T, Hanazaki K:Hyperglycemia during hepatic resection: continuous monitoring of blood glucose concentration. Am J Surg 2009; [Epub ahead of print]

6.Namikawa T, Kobayashi M, Iwabu J, Kitagawa H, Maeda H, Okabayashi T, Iguchi M, Hiroi M, Hanazaki K:Primary undifferentiated carcinoma of the small intestine: an immunohistochemical study and review of the literature.Med Mol Morphol 2009; (in press)

7.Namikawa T, Kobayashi M, Kitagawa H, Okabayashi T, Dabanaka K, Okamoto K, Sugimoto T, Toi M, Hanazaki K:Early gastric cancer with widespread duodenal invasion within the mucosa. Dig Endosc 2009; (in press)

8.Namikawa T, Kitagawa H, Iwabu J, Okabayashi T, Sugimoto T, Kobayashi M, Hanazaki K:Clinicopathological properties of the superficial spreading type early gastric cancer.J Gastrointest Surg 2009; [Epub ahead of print]

9.Hashimoto N, Yachida S, Okano K, Wakabayashi H, Imaida K, Kurokohchi K, Masaki T, Kinoshita H, Tominaga M, Ajiki T, Okabayashi T, Hanazaki K, Hiroi M, Izumi S, Mano S, Okada S, Karasawa Y, Maeba T, Suzuki Y:Immunohistochemically Detected Expression of p27(Kip1) and Skp2 Predicts Survival in Patients with Intrahepatic Cholangiocarcinomas.Ann Surg Oncol 2009;16:395-403

10.Yamashita K, Okabayashi T, Yokoyama T, Yatabe T, Maeda H, Manabe M, Hanazaki K:Accuracy and reliability of continuous blood glucose monitor in post-surgical patients. Acta Anaesthesiol Scand 2009; 53:66-71

11.Kitagawa H, Akimori T, Okabayashi T, Namikawa T, Sugimoto T, Kobayashi M, Hanazaki K:
Total laparoscopic gastric mobilization for esophagectomy. Langenbecks Arch Surg 2009;394:617-621

12.Okabayashi T, Nishimori I, Yamashita K, Sugimoto T, Maeda H, Yatabe T, Kohsaki T, Kobayashi M, Hanazaki K:Continuous postoperative blood glucose monitoring and control by an artificial pancreas in patients undergoing pancreatic resection: a prospective randomized clinical trial. Arch Surg 2009; 144:933-937

13.Munekage M, Okabayashi T, Hokimoto N, Sugimoto T, Maeda H, Namikawa T, Dabanaka K, Kobayashi M, Araki K, Hanazaki K:A case with synchronous multiple liver metastases from gastric carcinoma: postopera long-term disease-free survival. Langenbeck's Arch Surg 2009; 394:749-753

14.Namikawa T, Hanazaki K:Clinical analysis of primary anaplastic carcinoma of the small intestine. World J Gastroenterol 2009; 15:526-530

15.Okabayashi T, Maeda H, Nishimori I, Sugimoto T, Ikeno T, Hanazaki K:Pancreatic Fistula Formation after Pancreaticooduodenectomy; For Prevention of This Deep Surgical Site Infection after Pancreatic Surgery. Hepato-Gastroenterology 2009; 56:519-523

16.Namikawa T, Hanazaki K:Clinicopathological features of early gastric cancer with duodenal invasion.World J Gastroenterol 2009; 15:2309-2313

17.Okabayashi T, Nishimori I, Maeda H, Yamashita K, Yatabe T, Hanazaki K:Effect of intensive insulin therapy using a closed-loop glycemic control system in hepatic resection patients: a prospective randomized clinical trial.Diabetes Care 2009; 32:1425-1427

18.Uemura S, Maeda H, Munekage M, Yoshioka R, Okabayashi T, Hanazaki K:Hepatic Resection for Metastatic Colon Cancer in Patients with Situs Inversus Tatalis Complicated by Multiple Anomalies of the Hepatobiliary System: The First Case Report.J Gastrointest Surg 2009; 13:1724-1727

19.Okabayashi T, Nishimori I, Yamashita K, Sugimoto T, Yatabe T, Maeda H, Kobayashi M, Hanazaki K:Risk factors and predictors for surgical site infection after hepatic resection. J Hosp Infec 2009; 73:47-53

20.Yatabe T, Yokoyama T, Yamashita K, Okabayashi T, Hanazaki K:Increase in Blood Glucose with the Start of the Reperfusion After Large Vessel Surgery. Anesthe Analg 2009; 109:684

21.Maeda H, Okabayashi T, Yatabe T, Yamashita K, Hanazaki K: Perioperative intensive insulin therapy using artificial endocrine pancreas in patients undergoing pancreatectomy. World J Gastroenterol 2009; 15:4111-4115

22.Okabayashi T, Maeda H, Sun Z.L, Montgomery R.A., Nishimori I, Hanazaki K:Perioperative insulin therapy using a closed-loop artificial endocrine pancreas after hepatic resection Perioperative insulin therapy using a closed-loop artificial endocrine pancreas after hepatic resection. World J Gastroenterol 2009; 4116-4121

23.Namikawa T, Kobayashi M, Kitagawa H, Okabayashi T, Sugimoto T, Kuratani Y, Matsumoto M, Hanazaki K:Differentiated adenocarcinoma with a gastric phenotype in the stomach: difficulties in clinical and pathological diagnoses. Clin J Gastroenterol 2009; 2:268-274

24.Okabayashi T, Sun ZL, Montgomery RA, Hanazaki K:Surgical outcome of carcinosarcoma of the gall bladder: a review. World J Gastroenterol 2009; 15:4877-4882

25.Okabayashi T, Nishimori I, Sugimoto T, Maeda H, Dabanaka K, Onishi S, Kobayashi M, Hanazaki K.: Effects of branched-chain amino acids-enriched nutrient support for patients undergoing liver resection for hepatocellular carcinoma. J Gastroenterol Hepatol. 2008; 23:1869-1873

26.Okabayashi T, Hanazaki K: Surgical outcome of adenosquamous carcinoma of the pancreas. World J Gastroenterol 2008; 14:6765-6770

27.Okamoto K, Hanazaki K, Akimori T, Okabayashi T, Okada T, Kobayashi M, Ogata T: Immunohistochemical and electron microscopic characterization of bruch cells of the rat cecum. Med Mol Morohol 2008; 41: 145-150

28.Okabayashi T, Hanazaki K, Nishimori I, Sugimoto T, Yoshioka R, Dabanaka K, Kobayashi M, Onishi S.: Pancreatic transection using a sharp hook-shaped ultrasonically activated scalpel. Langenbecks Arch Surg 2008; 393:1005-1008

29.Okabayashi T, Nishimori I, Nishioka A, Yamashita K, Sugimoto T, Dabanaka K, Maeda H, Kohsaki T, Ogawa Y, Kobayashi M, Onishi S, Hanazaki K: Long-term effects of multimodal treatment for patients with resectable carcinoma of the pancreas. Oncol Rep 2008; 20: 651-656

30.Yoshioka R, Okabayashi T, Nishimori I, Maeda H, Sugimoto T, Kosaki T, Onishi S, Fukaya T, Kobayashi M, Hanazaki K: Along-survived case with solitary splenic metastasis from ovarian carcinoma. Sugg Technol Int 2008; 17: 192-194

31.Nakano T, Sonobe H, Usui T, Yamanaka K, Ishizuka T, Nishimura E, Hanazaki K: Immunohistochemistry and K-ras sequence of pancreatic carcinosarcoma. Pathol Int 2008; 58:672-677

32.Okabayashi T, Hanazaki K: Overwhelming postsplenectomy infection syndrome in adults - A clinically preventable disease. World J Gastroenterol 2008; 14:176-179

33.Yamashita K, Hanazaki K, et. Al. The accuracy of a continuous blood glucose monitor during surgery. Anesth Analg 2008; 106: 160-163

34.Maeda H, Hanazaki K, et. Al. Clinicopathological features of adenocarcinoma at the gastric cardia; is it different from distal cancer of the stomach?. J Am Coll Surg 2008; 206: 306-310

35.Okabayashi T, Hanazaki K, et. Al. Clinicopathological features and medical management of early gastric cancer. Am J Surg 2008; 195:229-232

36.Okabayashi T, Hnazaki K, et. Al. Continuous Post-operative Blood Glucose Monitoring and Control Using a Closed-loop System in Patients Undergoing Hepatic Resection. Dig Dis Sci 2008; 53: 1405-10.

37.Okabayashi T, Hanazaki K, et. Al. The Benefit of the Supplementation of Perioperative Branched-Chain Amino Acids in Patients with Surgical Management for Hepatocellular Carcinoma: a Preliminary Study. 2008; Dig Dis Sci 53: 204-209

38.Kuroda N, Tanida N, Oonishi K, Inoue K, Ohara M, Mizuno K, Taguchi T, Hayashi Y, Hanazaki K, Lee G: Significance of D2-40 expression in the diagnosis of gastrointestinal stromal tumor. Med Mol Morphol 2008; 41: 109-112

39.花ア和弘、岡林雄大、前田広道、北川博之、杉本健樹、矢田部智昭、山下幸一、西森功:
手術周術期における人工膵を用いた血糖管理. ICUとCCU 2008; 32:805-813

40.花ア和弘、岡林雄大、前田広道、矢田部智昭、山下幸一、西森功、小川道雄: 人工膵臓を用いた外科手術周術期血糖管理法@周術期における血糖管理に重要性について. 胆と膵 2008; 29:861-866

41.花ア和弘: 爪周囲炎・陥入爪の処置. 外科 2008; 70:1393-1397

42.花ア和弘:人工膵臓って何?W Waves JSCT(日本癌病態治療研究会誌)2008; 14: 55-56

43.並川努、小林道也、花ア和弘: 消化管機能からみたU領域早期胃癌に対する噴門側胃切除後空腸嚢間置再建術の評価. 消化と吸収 2008; 30:23-26

44.甫喜本憲弘、市川賢吾、藤原千子、尾崎信三、上岡教人、花ア和弘: ENBDチューブの逸脱により生じたと考えられる十二指腸穿孔の1例. 日本臨床外科学会雑誌 2008; 69: 2537-2541

45.杉本健樹、船越拓、花ア和弘、中内優、末廣史恵、坪崎英治、濱田和香、岡本裕美子、岡田由佳、武市昌士: CRマンモグラフィのソフトコピーを用いた遠隔診断. 日本乳癌検診学会雑誌 2008 ;17:215-220

46.岡林雄大、前田広道、花ア和弘: 外科感染症対策を目的とした外科周術期に人工膵臓を用いた血糖管理法の現状と将来展望. 日本感染症学会雑誌 2008; 5:177-181

47.味村俊樹、倉本秋、駄場中研、岡本健、小林道也、花崎和弘: Diversion colitis(便流変更性大腸炎/空置性大腸炎)とは. 臨床看護 2008; 34:1549-1556

48.矢田部智昭、横山武志、山下幸一、岡林雄大、真鍋雅信、花ア和弘: 人工膵臓STG-22を用いて管理したインスリノーマの1症例. 臨床麻酔 2008; 32:1412-1414

49.Hanazaki K, Ogawa M: Current status of ICU-based glycemic control and outlook for the artificial pancreas-glycemic control using the artificial pancreas. Latest findings- The 44th annual meeting of the Japanese Society for Artificial Organs Luncheon Seminar. Nikkiso Original Technologies. 2007; P1-6

50.花崎和弘、岡林雄大、前田広道: 中部・下部胆管癌に対する幽門輪温存膵頭十二指腸切除術;シャープフック型ハーモニックスカルペルを用いた膵切離法. 消化器外科 2007; 30:1291-1301

51.並川努、小林道也、花崎和弘: 消化管機能からみたU領域早期胃癌に対する噴門側胃切除後空腸嚢間置再建術の評価. Jap Soc Digest Absorption 2007; 30:23-26

52.Nakano T, Hanazaki K, et. Al. Effects of geldanamy in and thalidomide on the Th1/Th2 cytokine balance in mice subjected to operative trauma. Surg 2007;141: 490-500

53.Maeda H, Hanazaki K,et. Al. Duodenum-preserving pancreatic head resection for pancreatic metastasis from renal cell carcinoma: a case report. Langenbeck's Arch Surg 2007;392: 649-652

54.Okabayashi T, Hanazaki K, et. Al. Risk factors in pancreatic fistula after pancreatic head resection. J Hepato-Biliary-Pancreat Surg 2007; 14:557-563

55.Namikawa T, Hanazaki K, et. Al. Clinicopathological Analysis of Idiopathic Perforation of the Gallbladder. Surg Today 2007; 37: 633-637

56.Namikawa T, Kobayashi M, Okamoto K, Okabayashi T, Akimori T, Sugimoto T, Hanazaki K: Recurrence of gastric cancer in the jejunal pouch after completion gastrectomy. Gastric Cancer 2007; 10: 256-259

57.Okamoto K, Kobayashi M, Okabayashi T, Sugimoto T, Nishimori I, Ohnishi S, Hanazaki K: Pancreatic metastasis from renal cell carcinoma: Report of three resected cases and revew of Japanese. Hepato-Gastroenterol 2007; 4:937-940

58.Okabayashi T, Hanazaki K, et. Al. Autopsy study of anatomical features of the posterior gastric artery for surgical contribution.World J Gastroenterol 2006; 12:5357-5359

59.Nishimori I, Hanazaki K, et. Al. Non-cystic solid-pseudopapillary tumor of the pancreas showing nuclear accumulation and activating gene mutation of β-catenin. Pathol Int 2006;56:707-711

60.花崎和弘、他:シャープフック型ハーモニックスカルペルを用いた膵頭十二指腸切除の膵切離法.手術 2006; 60:343-347.

61.花崎和弘、他:外科領域における肝癌に対するRFAの適応に関する検討.外科治療 2006; 94:754-758.

62.Hanazaki K, et al. Perioperative blood transfusion and survival following curative hepatic resection for hepatocellular carcinoma. Hepatogastroenterol 2005; 52: 524-529.

63.Hanazaki K, et al. Risk factors of long-term survival and recurrence after curative resection of hepatocellular carcinoma. Hepatogastroenterol 2005; 52: 552-557.

64.Kono T, Hanazaki K, et al. Pancreatic polypeptide administration reduces insulin requirements of artificial pancreas in pancreatectomized dogs. Artif Organs 2005; 29: 183-87.

65.Hanazaki K, et al. Risk factors of intrahepatic recurrence after curative resection of hepatocellular carcinoma. Hepatogastroenterol 2005; 52: 580-586.

66.Hanazaki K. Antiviral therapy for chronic hepatitis B: A Review: Curr Drug Targets Inflamm Allergy. 2004;3:63-70.

67.Shimozawa N, Hanazaki K. Longterm prognosis after hepatic resection for small hepatocellular carcinoma. J Am Coll Surg 2004; 198: 356-365.



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