■ 氏名
東 洋一郎 (ヒガシ ヨウイチロウ)
HIGASHI Yoichiro

■ 所属部局/職名
Research and Education Faculty, Medical Sciences Cluster, Basic Medicine Unit/Assistant Professor
教育研究部 医療学系 基礎医学部門/助教

■ 学部・学科・コース等
Medical School, Medical Course, Department of Pharmacology
医学部 医学科 薬理学

■ 連絡先
住 所
電 話088-880-2397
F A X
E-Mailhigasi●kochi-u.ac.jp    (送信の際は“●”を半角の“@”に変更して送信してください。)
U R L

■ 卒業大学及び大学院等
岡山大学大学院

■ 学位(種類)
医学博士

■ 所属学会
日本神経科学会、日本神経化学会、日本分子生物学会、Society for Neuroscience

■ 専門分野
神経再生医療学、神経科学、分子細胞生物学

■ 主な研究テーマ・活動
ES細胞や神経幹細胞を用いた脳内免疫応答の解析とそれに基づいた神経再生療法ならびに新しいリハビリテーションの開発。脳内亜鉛によるミクログリアの活性化とその役割の解析。

■ 研究についてのPR

■ 社会人・生徒を対象として可能な講演・授業(例えば講演題目)
神経科学、分子生物学

■ 研究業績
kauppinen TM, Higashi Y, Suh SW, Escartin C, Nagasawa K, and Swanson RA: Zinc triggers microglial activation. J Neurosci. May 28;28(22):5827-35. 2008

Nakamuta S, Endo H, Higashi Y, Kousaka A, Yamada H, Yano M, and Kido H: Human immunodeficiency virus type 1 gp120-mediated disruption of tight junction proteins by induction of proteasome-mediated degradation of zonula occludens-1 and -2 in human brain microvascular endothelial cells. J Neurovirol. May;14(3):186-95. 2008

Nagasawa K, Kakuda T, Higashi Y, and Fujimoto S: Possible involvement of 12-lipoxygenase activation in glucose-deprivation/reload-treated neurons. Neurosci Lett. Dec 18;429(2-3):120-5. 2007

Shimizu M, Miyazaki I, Higashi Y, Eslava-Alva MJ, Diaz-Corrales FJ, Asanuma M, and Ogawa N: Specific induction of PAG608 in cranial and spinal motor neurons of L-DOPA-treated parkinsonian rats. Neurosci Res. Apr;60(4):355-63. 2007

Asanuma M, Miyazaki I, Higashi Y, Diaz-Corrales FJ, Shimizu M, Miyoshi K and Ogawa N: Suppression of p53-activated gene, PAG608, attenuates methamphetamine-induced neurotoxicity. Neurosci Lett. Mar: 13;414(3): 263-7. 2007

Yamada H, Le QT, Kousaka A, Higashi Y, Tsukane M and Kido H: Sendai virus infection up-regulates trypsin I and matrix metalloproteinase-9, triggering viral multiplication and matrix degradation in rat lungs and lung L2 cells. Arch Virol. Dec: 151(12): 2529-37. 2006

Yamada H, Chounan R, Higashi Y, Kurihara N and Kido H: Mitochondrial targeting sequence of the influenza A virus PB1-F2 protein and its function in mitochondria. FEBS Lett. Dec: 17;578(3): 331-6. 2004

Asanuma M, Miyazaki I, Higashi Y, Tsuji T and Ogawa N: Specific gene expression and possible involvement of inflammation in methamphetamine-induced neurotoxicity. Ann NY Acad Sci. Oct: 1025: 69-75. 2004

Higashi Y, Asanuma M, Miyazaki I and Ogawa N: Expression of metallothionein-III and cell death in differentiated catecholaminergic neuronal cells. Neurol. Res. Sep: 26 (6):671-6. 2004

Higashi Y, Asanuma M, Miyazaki I, Hattori N, Mizuno Y and Ogawa N: Parkin attenuates manganese-induced dopaminergic cell death. J Neurochem. Jun: 89(6):1490-7. 2004

Haque ME, Asanuma M, Higashi Y, Miyazaki I, Tanaka K and Ogawa N: Overexpression of Cu-Zn superoxide dismutase protects neuroblastoma cells against dopamine cytotoxicity accompanied by increase in their glutathione level. Neurosci Res. Sep: 47(1):31-7. 2003

Tanaka K, Fujita N, Higashi Y and Ogawa N: Neuroprotective and antioxidant properties of FKBP-binding immunophilin ligands are independent on the FKBP12 pathway in human cells. Neurosci Lett. Sep: 20;330(2): 147-50. 2002

Higashi Y, Asanuma M, Miyazaki I, Haque ME, Fujita N. Tanaka K and Ogawa N: The p53-activated gene, PAG608, requires a zinc finger domain for nuclear localization and oxidative stress-induced apoptosis. J Biol Chem. Nov: 1;277(44): 42224-32. Aug 23. 2002

Miyazaki I, Asanuma M, Higashi Y, Sogawa CA., Tanaka K and Ogawa : Age-related changes in expression of metallothionein-III in rat brain. Neurosci Res. Aug: 43(4): 323-33. 2002

Yoshioka M, Tanaka K, Miyazaki I, Fujita N, Higashi Y, Asanuma M and Ogawa N: The dopamine agonist cabergoline provides neuroprotection by activation of the glutathione system and scavenging free radicals. Neurosci Res. Jul: 43(3): 259-67. 2002

Asanuma M, Miyazaki I, Higashi Y, Tanaka K, Haque ME, Fujita N and Ogawa N: Aggravation of 6-hydroxydopamine-induced dopaminergic lesions in metallothionein-I and -II knock-out mouse brain. Neurosci Lett. Jul: 12;327(1): 61-5. 2002

Tanaka K, Fujita N, Higashi Y and Ogawa N: Effects of immunophilin ligands on hydrogen peroxide-induced apoptosis in C6 glioma cells. Synapse. Mar: 1;43(3): 219-22. 2002

Miyazaki I, Sogawa CA, Asanuma M, Higashi Y, Tanaka KI, Nakanishi T and Ogawa N: Expression of metallothionein-III mRNA and its regulation by levodopa in the basal ganglia of hemi-parkinsonian rats. Neurosci Lett. Oct: 20;293(1): 65-8. 2000

Higashi Y, Asanuma M, Miyazaki I and Ogawa N: Inhibition of tyrosinase reduces cell viability in catecholaminergic neuronal cells. J Neurochem. Oct: 75(4): 1771-4. 2000


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