■ 氏名
横山 正尚 (ヨコヤマ マサタカ)
YOKOYAMA Masataka

■ 所属部局/職名
Research and Education Faculty, Medical Sciences Cluster, Clinical Medicine Unit/Professor
教育研究部 医療学系 臨床医学部門/教授

■ 学部・学科・コース等
Medical School, Medical Course, Department of Anesthesiology and Intensive Care Medicine
医学部 医学科 麻酔科学・集中治療医学

■ 連絡先
住 所
電 話088-880-2471
F A X
E-Mailmasayoko●kochi-u.ac.jp    (送信の際は“●”を半角の“@”に変更して送信してください。)
U R L

■ 卒業大学及び大学院等
岡山大学

■ 学位(種類)
医学博士

■ 所属学会
日本麻酔科学会、日本ペインクリニック学会、日本集中治療医学会、日本蘇生学会

■ 専門分野
麻酔科学、疼痛学、集中治療学

■ 主な研究テーマ・活動
麻酔と免疫・ストレス反応
疼痛の分子レベルの機序解明と遺伝子治療

■ 研究についてのPR
「麻酔と免疫・ストレス反応」
麻酔方法や術後鎮痛法が術後の合併症や長期の生存率に影響を及ぼす可能性が示唆されている。麻酔方法や術後の鎮痛法を各患者の背景に考慮して、よりよい周術期の管理をすることを目指して、多施設研究でエビデンスを探求している。
「疼痛の分子レベルの機序解明と遺伝子治療」
疼痛の機序はいまだ、未解決の分野が多く残っている。このことが癌性疼痛や難治性疼痛の治療を困難としている。分子レベルでこの問題を解決すると共に、疼痛で特異的に増加している疼痛関連物質を脊髄レベルでノックダウンすることで、根治的な難治性疼痛の治療に結びつけようと研究している。

■ 社会人・生徒を対象として可能な講演・授業(例えば講演題目)
麻酔概論
痛みの機序と治療
周術期管理

■ 研究業績
 Omori M, Yokoyama M, Matsuoka Y, Kobayashi H, Mizobuchi S, Itano Y, Morita K, Ichikawa H. Effects of selective spinal nerve ligation on acetic acid-induced nociceptive responses and ASIC3 immunoreactivity in the rat dorsal root ganglion. Brain Res 2008: 1219: 26-31.
 Hanazaki M, Yokoyama M, Morita K, Kohjitani A, Sakai H, Chiba Y, Misawa M. Rho-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contraction. Anesth Analg 2008: 106: 1765-71.
 Kobayashi H, Yokoyama M, Matsuoka Y, Omori M, Itano Y, Kaku R, Kiyoshi M, Ichikawa H.Expression changes of multiple brain-derived neurotrophic factor transcripts in selective spinal nerve ligation model and complete Freund’s adjuvant model. Brain Res 2008; 1206: 13-9.
 Matsuoka Y, Yokoyama M, Kobayashi H, Omori M, Itano Y, Morita K, Mori H, Nakanishi T. Expression profiles of BDNF splice variants in cultured DRG neurons stimulated with NGF. Biochem Biophys Res Commun: 2007: 362:682-8.
 Ishikawa S, Yokoyama M, Mizobuchi S, Hashimoto H, Moriyama E, Morita K.Epidural blood patch therapy for chronic whiplash-associated disorder. Anesth Analg. 2007; 105: 809-14.
 Kaku R, Yokoyama M, Kobayashi H, Matsuoka Y, Sato T, Mizobuchi S, Itano Y, Morita K. Altered response to formalin by L5 spinal nerve ligation in rats: a behavioral and molecular study. Anesth Analg. 2007: 104: 936-43.
 Kawakami T, Takahashi T, Shimizu H, Nakahira K, Takeuchi M, Katayama H, Yokoyama M, Morita K, Akagi R, Sassa S. Highly liver-specific heme oxygenase-1 induction by interleukin-11 prevents carbon tetrachloride-induced hepatotoxicity. Int J Mol Med. 2006; 18: 537-46.
 Morimatsu H, Takahashi T, Maeshima K, Inoue K, Kawakami T, Shimizu H, Takeuchi M, Yokoyama M, Katayama H, Morita K. Increased heme catabolism in critically ill patients: correlation among exhaled carbon monoxide, arterial carboxyhemoglobin, and serum IXαconcentrations. Am J Phisiol Lung Cell Mol Physiol. 2006; 290: L114-9.
 Yokoyama M, Itano Y, Katayama H, Morimatsu H, Takeda Y, Takahashi T, Nagano O, Morita K: The effects of continuous epidural anesthesia and analgesia on stress response and immune function in patients undergoing radical esophagectomy. Anesth Analg. 2005; 101: 1521-7.
 Nagano I, Shiote M, Murakami T, Kamada H, Hamakawa Y, Matsubara E, Yokoyama M, Morita K, Shoji M, Abe K. Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis. Neurol Res. 2005; 27: 768-72.
 Takata K, Takeda Y, Sato T, Nakatsuka H, Yokoyama M, Morita K. Effects of hypothermia for a short period on histologic outcome and extracellular glutamate concentration during and after cardiac arrest in rats.Crit Care Med. 2005; 33: 1340-5.
 Maeshima K, Takahashi T, Uehara K, Shimizu H, Omori E, Yokoyama M, Tani T, Akagi R, Morita K: Prevention of hemorrahagic shock-induced lung injury by heme arginate treatment in rats. Biochem Pharmacol. 2005; 69: 1667-80.
 Uehara K, Takahashi T, Fujii H, Shimizu H, Omori E, Matsumi M, Yokoyama M, Morita K, Akagi R, Sassa S. The lower intestinal tract-specific induction of heme oxygenase-1 by glutamine protects against endotoxemic intestinal injury. Crit Care Med. 2005; 33: 381-90.
 Hayashi M, Takahashi T, Morimatsu H, Fujii H, Taga N, Mizobuchi S, Matsumi M, Katayama H, Yokoyama M, Taniguchi M, Morita K. Increased carbon monoxide concentration in exhaled air after surgery anesthesia. Anesth Analg. 2004; 99: 444-8.
 Yokoyama M, Hanazaki M, Fujii H, Mizobuchi S, Nakatsuka H, Takahashi T, Matsumi M, Takeuchi M, Morita K. Correlation between the distribution of contrast medium and the extent of blockade during epidural anesthesia. Anesthesiology. 2004; 100: 1504-10.
 Yokoyama M, Sun X, Oku S, Taga N, Sato K, Mizobuchi S, Takahashi T, Morita K. Comparison of percutaneous electrical nerve stimulation with transcutaneous electrical nerve stimulation for long-term pain relief in patients with chronic low back pain. Anesth Analg. 2004; 98: 1552-6.
 Sun X, Yokoyama M, Mizobuchi S, Kaku R, Nakatsuka H, Takahashi T, Morita K. The effects of pretreatment with lidocaine or bupivacaine on the spatial and temporal expression of c-Fos protein in the spinal cord caused by plantar incision in the rat. Anesth Analg. 2004; 98:1093-8.
 Maeshima K, Takahashi T, Nakahara K, Shimizu H, Fujii H, Katayama H, Yokoyama M, Morita K, Akagi R, Sassa S. A protective role of interleukin 11 on hepatic injury in acute endotoxemia. Shock. 2004; 21:134-8.
 Nakahira K, Takahashi T, Shimizu H, Maeshima K, Uehara K, Fujii H, Nakatsuka H, Yokoyama M, Akagi R, Morita K. Protective role of heme oxygenase-1 induction in carbon tetrachloride-induced hepatotoxicity. Biochem Pharmacol.
 Yokoyama M, Itano Y, Kusume Y, Oe K, Mizobuchi S, Morita K. Total spinal anesthesia provides transient relief of intractable pain. Can J Anaesth. 2002; 49: 810-3.
 Yokoyama M, Ohashi I, Nakatsuka H, Mizobuchi S, Toda Y,
Matsumi M, Morita Y, Hirakawa M. Drug-induced liver disease during continuous epidural block with bupivacaine. Anesthesiology. 2001; 95: 259-61.
 Yokoyama M, Mizobuchi S, Nagano O, Fujii H, Yamashita M, Hirakawa M.
The Effects of epidural insertion site and surgical procedure on plasma lidocaine concentration. Anesth Analg. 2001; 92: 470-5.
 Yokoyama M, Itano Y, Mizobuchi S, Nakatsuka H, Kaku R, Takashima T, Hirakawa M. The effects of epidural block on the distribution of lymphocyte subsets and natural-killer cell activity in patients with and without pain. Anesth Analg. 2001: 92: 463-9.
 Yokoyama M, Ueda W, Hirakawa M: Haemodynamic effects of the lateral decubitus position and the kidney rest decubitus position during anaesthesia. Br J Anaesth.
 Yokoyama M, Nakatsuka H, Itano Y, Hirakawa M. Stellate ganglion block modifies the distribution of lymphocyte subsets and natural-killer cell activity. Anesthesiology. 2000; 92: 109-15.


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