■ 氏名
佐野 栄紀 (サノ シゲトシ)
SANO Shigetoshi

■ 所属部局/職名
Research and Education Faculty, Medical Sciences Cluster, Clinical Medicine Unit/Professor
教育研究部 医療学系 臨床医学部門/教授

■ 学部・学科・コース等
Medical School, Medical Course, Department of Dermatology
医学部 医学科 皮膚科学

■ 連絡先
住 所
電 話
F A X
E-Mail
U R L

■ 出身大学院・研究科等

■ 出身学校・専攻等

■ 取得学位
医学博士 () 大阪大学

■ 研究職歴

■ 委員歴・役員歴

■ 受賞学術賞

■ 所属学会

■ 専門分野

■ 主な研究テーマ・活動

■ 研究についてのPR

■ 社会人・生徒を対象として可能な講演・授業(例えば講演題目)

■ 研究業績(論文・解説)
Skin and hair abnormalities of Cantu syndrome: A congenital hypertrichosis due to a genetic alteration mimicking the pharmacological effect of minoxidil.
 The Journal of dermatology (Ohko K, Nakajima K, Nakajima H, Hiraki Y, Kubota K, Fukao T, Miyatake S, Matsumoto N, Sano S) /, 202001 () 10.1111/1346-8138.15216

Japanese guidance for use of biologics for psoriasis (the 2019 version).
 The Journal of dermatology (Saeki H, Terui T, Morita A, Sano S, Imafuku S, Asahina A, Komine M, Etoh T, Igarashi A, Torii H, Abe M, Nakagawa H, Watanabe A, Yotsuyanagi H, Ohtsuki M, Biologics Review Committee of the Japanese Dermatological Association for Psoriasis: Chair: Mamitaro Ohtsuki.) /, 202001 () 10.1111/1346-8138.15196

CRISPR-Cas3 induces broad and unidirectional genome editing in human cells.
 Nature communications (Morisaka H, Yoshimi K, Okuzaki Y, Gee P, Kunihiro Y, Sonpho E, Xu H, Sasakawa N, Naito Y, Nakada S, Yamamoto T, Sano S, Hotta A, Takeda J, Mashimo T) 10/1, 5302 201912 () 10.1038/s41467-019-13226-x

Possible involvement of zinc transporter ZIP10 in atopic dermatitis.
 The Journal of dermatology (Nakajima K, Lee MG, Bin BH, Hara T, Takagishi T, Chae S, Sano S, Fukada T) /, 201912 () 10.1111/1346-8138.15190

IL-36 Signaling Is Essential for Psoriatic Inflammation?through the Augmentation of?Innate?Immune Responses.
 The Journal of investigative dermatology (Ohko K, Nakajima K, Kataoka S, Takaishi M, Sano S) 139/6, 1400-1404 201906 () 10.1016/j.jid.2018.12.003

Favorable response to apremilast in a patient with refractory psoriasis verrucosa.
 The Journal of dermatology (Okazaki S, Osawa R, Nakajima H, Nakajima K, Sano S) 46/6, 544-547 201906 () 10.1111/1346-8138.14877

Prevalence and Viral Loads of Cutaneous Human Polyomaviruses in the Skin of Patients With Chronic Inflammatory Skin Diseases.
 The Journal of infectious diseases (Hashida Y, Higuchi T, Tanaka M, Shibata Y, Nakajima K, Sano S, Daibata M) 219/10, 1564-1573 201904 () 10.1093/infdis/jiy618

Switching biologics in the treatment of psoriatic arthritis in Japan.
 The Journal of dermatology (Yamamoto T, Ohtsuki M, Sano S, Morita A, Igarashi A, Okuyama R, Kawada A, working group of the epidemiological survey in the Japanese Society for Psoriasis Research.) 46/3, e113-e114 201903 () 10.1111/1346-8138.14622

Real-World Postmarketing Study of the Impact of Adalimumab Treatment on Work Productivity and Activity Impairment in Patients with Psoriatic Arthritis.
 Advances in therapy (Nakagawa H, Tanaka Y, Sano S, Kameda H, Taniguchi A, Kashiwagi T, Kawaberi T, Kimura J, Morita A) 36/3, 691-707 201903 () 10.1007/s12325-018-0866-y

Stat3 activation in epidermal keratinocytes induces Langerhans cell activation to form an essential circuit for psoriasis via IL-23 production.
 Journal of dermatological science (Nakajima K, Kataoka S, Sato K, Takaishi M, Yamamoto M, Nakajima H, Sano S) 93/2, 82-91 201902 () 10.1016/j.jdermsci.2018.11.007

Transdifferentiation of Melanoma Cells by the Reprogramming Factors Attenuates Malignant Nature In?Vitro and In?Vivo.
 The Journal of investigative dermatology (Takaishi M, Sano S) 139/1, 254-257 201901 () 10.1016/j.jid.2018.06.179

Re-investigating the Basement Membrane Zone of Psoriatic Epidermal Lesions: Is Laminin-511 a New Player in Psoriasis Pathogenesis?
 The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society (Natsumi A, Sugawara K, Yasumizu M, Mizukami Y, Sano S, Morita A, Paus R, Tsuruta D) 66/12, 847-862 201812 () 10.1369/0022155418782693

Japanese guidelines for the management and treatment of generalized pustular psoriasis: The new pathogenesis and treatment of GPP.
 The Journal of dermatology (Fujita H, Terui T, Hayama K, Akiyama M, Ikeda S, Mabuchi T, Ozawa A, Kanekura T, Kurosawa M, Komine M, Nakajima K, Sano S, Nemoto O, Muto M, Imai Y, Yamanishi K, Aoyama Y, Iwatsuki K, Japanese Dermatological Association Guidelines Development Committee for the Guidelines for the Management and Treatment of Generalized Pustular Psoriasis.) 45/11, 1235-1270 201811 () 10.1111/1346-8138.14523

Angiosarcoma associated with hypertrichosis.
 European journal of dermatology : EJD (Shibata Y, Matsumoto Y, Shiga T, Nakajima H, Nakajima K, Sano S) 28/5, 677-678 201810 () 10.1684/ejd.2018.3337

Regnase-1, an Immunomodulator, Limits the?IL-36/IL-36R Autostimulatory Loop in Keratinocytes to Suppress Skin Inflammation.
 The Journal of investigative dermatology (Takaishi M, Satoh T, Akira S, Sano S) 138/6, 1439-1442 201806 () 10.1016/j.jid.2017.12.033

Juvenile-onset psoriatic arthritis: a survey by the Japanese Society for Psoriasis Research.
 European journal of dermatology : EJD (Yamamoto T, Ohtsuki M, Sano S, Igarashi A, Morita A, Okuyama R, Wada M, Katoh N, Kawada A) 28/3, 419-421 201806 () 10.1684/ejd.2018.3286

Guselkumab, a human interleukin-23 monoclonal antibody in Japanese patients with generalized pustular psoriasis and erythrodermic psoriasis: Efficacy and safety analyses of a 52-week, phase 3, multicenter, open-label study.
 The Journal of dermatology (Sano S, Kubo H, Morishima H, Goto R, Zheng R, Nakagawa H) 45/5, 529-539 201805 () 10.1111/1346-8138.14294

Distinct kinetics of two pathologies induced in mice by topical treatment with imiquimod cream: Psoriasis-like inflammation and systemic autoimmunity.
 Journal of dermatological science (Kataoka S, Yamamoto M, Ohko K, Nakajima K, Sano S) /, 201805 () 10.1016/j.jdermsci.2018.05.001

Anti-transcription intermediary factor 1γ antibody titer correlates with clinical symptoms in a patient with recurrent dermatomyositis associated with ovarian cancer.
 International journal of rheumatic diseases (Teraishi M, Nakajima K, Ishimoto T, Yamamoto M, Maeda N, Muro Y, Sano S) 21/4, 900-902 201804 () 10.1111/1756-185X.13264

Use of intralesional blood to determine diffusible biomarkers from skin lesions.
 Journal of dermatological science (Ishimoto T, Kataoka S, Shiga T, Takaishi M, Sano S) 90/1, 75-81 201804 () 10.1016/j.jdermsci.2018.01.001

Genetic Variability of the Noncoding Control Region of Cutaneous Merkel Cell Polyomavirus: Identification of Geographically Related Genotypes.
 The Journal of infectious diseases (Hashida Y, Higuchi T, Matsui K, Shibata Y, Nakajima K, Sano S, Daibata M) 217/10, 1601-1611 201804 () 10.1093/infdis/jiy070

Mouse models of psoriasis and their relevance.
 The Journal of dermatology (Nakajima K, Sano S) 45/3, 252-263 201803 () 10.1111/1346-8138.14112

Knockout of the interleukin-36 receptor protects against renal ischemia-reperfusion injury by reduction of proinflammatory cytokines.
 Kidney international (Nishikawa H, Taniguchi Y, Matsumoto T, Arima N, Masaki M, Shimamura Y, Inoue K, Horino T, Fujimoto S, Ohko K, Komatsu T, Udaka K, Sano S, Terada Y) 93/3, 599-614 201803 () 10.1016/j.kint.2017.09.017

Prevalence and Genetic Variability of Human Polyomaviruses 6 and 7 in Healthy Skin Among Asymptomatic Individuals.
 The Journal of infectious diseases (Hashida Y, Higuchi T, Matsuzaki S, Nakajima K, Sano S, Daibata M) 217/3, 483-493 201801 () 10.1093/infdis/jix516

Can patch test sensitization with gold sodium thiosulfate be ruled out? - a case report.
 Contact dermatitis (Shibata Y, Ohko K, Sano S) 78/1, 94-95 201801 () 10.1111/cod.12864

Proposal for long-term protocols after Psoriasis Area and Severity Index clear with initial biologic therapy: Happily ever after with or without biologics in psoriasis therapy.
 The Journal of dermatology (Sano S) 44/10, e234-e235 201710 () 10.1111/1346-8138.13930

Iliopsoas and intraperitoneal abscesses associated with pyoderma gangrenosum.
 The Journal of dermatology (Takahashi A, Nakajima H, Sano S) 44/9, e218-e219 201709 () 10.1111/1346-8138.13904

Brief Report: Interleukin-17A-Dependent Asymmetric Stem Cell Divisions Are Increased in Human Psoriasis: A Mechanism Underlying Benign Hyperproliferation.
 Stem cells (Dayton, Ohio) (Charruyer A, Fong S, Vitcov GG, Sklar S, Tabernik L, Taneja M, Caputo M, Soeung C, Yue L, Uchida Y, Arron ST, Horton KM, Foster RD, Sano S, North JP, Ghadially R) 35/8, 2001-2007 201708 () 10.1002/stem.2656

The first nationwide surveillance of antibacterial susceptibility patterns of pathogens isolated from skin and soft-tissue infections in dermatology departments in Japan.
 Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (Watanabe S, Ohnishi T, Yuasa A, Kiyota H, Iwata S, Kaku M, Watanabe A, Sato J, Hanaki H, Manabe M, Suzuki T, Otsuka F, Aihara M, Iozumi K, Tamaki T, Funada Y, Shinozaki M, Kobayashi M, Okuda M, Kikyo G, Kikuchi K, Okada Y, Takeshima M, Kaneko O, Ogawa N, Ito R, Okuyama R, Shimada S, Shimizu T, Hatta N, Manabu M, Tsutsui K, Tanaka T, Miyachi Y, Asada H, Furukawa F, Kurokawa I, Iwatsuki K, Hide M, Muto M, Yamamoto O, Niihara H, Takagaki K, Kubota Y, Sayama K, Sano S, Furue M, Kanekura T) 23/8, 503-511 201708 () 10.1016/j.jiac.2017.05.006

Novel frame-shift mutation in SERPINB7 in a Japanese patient with Nagashima-type palmoplantar keratosis.
 The Journal of dermatology (Nakajima K, Ishiguro M, Shiohama A, Kubo A, Sano S) 44/7, 841-843 201707 () 10.1111/1346-8138.13556

Neutrophils are not the dominant interleukin-17 producer in psoriasis.
 The Journal of dermatology (Yamanaka K, Yamagiwa A, Akeda T, Kondo M, Kakeda M, Habe K, Imafuku S, Sano S, Mizutani H) 44/7, e170-e171 201707 () 10.1111/1346-8138.13807

Molecular identification of intramuscular and subcutaneous Spirometra erinaceiuropaei sparganosis in a Japanese patient.
 The Journal of dermatology (Kudo T, Fujioka A, Korenaga M, Yamasaki H, Morishima Y, Sugiyama H, Nakajima H, Sano S) 44/6, e138-e139 201706 () 10.1111/1346-8138.13739

Chlorothiazide-induced photoaggravation of psoriatic lesion during narrowband ultraviolet B treatment in a case of psoriasis vulgaris.
 The Journal of dermatology (Matsushima T, Nakajima H, Ohko K, Nakajima K, Sano S) 44/6, e122-e123 201706 () 10.1111/1346-8138.13764

Prevalence and current therapies of psoriatic arthritis in Japan: A survey by the Japanese Society of Psoriasis Research in 2016.
 The Journal of dermatology (Yamamoto T, Ohtsuki M, Sano S, Igarashi A, Morita A, Okuyama R, Kawada A, Working Group of the Epidemiological Survey in the Japanese Society for Psoriasis Research.) 44/6, e121 201706 () 10.1111/1346-8138.13800

Leucine-rich α-2 glycoprotein is an innovative biomarker for psoriasis.
 Journal of dermatological science (Nakajima H, Serada S, Fujimoto M, Naka T, Sano S) 86/2, 170-174 201705 () 10.1016/j.jdermsci.2017.01.008

Critical involvement of ZEB2 in collagen fibrillogenesis: the molecular similarity between Mowat-Wilson syndrome and Ehlers-Danlos syndrome.
 Scientific reports (Teraishi M, Takaishi M, Nakajima K, Ikeda M, Higashi Y, Shimoda S, Asada Y, Hijikata A, Ohara O, Hiraki Y, Mizuno S, Fukada T, Furukawa T, Wakamatsu N, Sano S) 7/, 46565 201704 () 10.1038/srep46565

Prevalence and clinical features of Fabry disease in Japanese male patients with diagnosis of hypertrophic cardiomyopathy.
 Journal of cardiology (Kubo T, Ochi Y, Baba Y, Hirota T, Tanioka K, Yamasaki N, Yoshimitsu M, Higuchi K, Takenaka T, Nakajima K, Togawa T, Tsukimura T, Sano S, Tei C, Sakuraba H, Kitaoka H) 69/1, 302-307 201701 () 10.1016/j.jjcc.2016.05.014

Oral administration of a novel RORγt antagonist attenuates psoriasis-like skin lesion of two independent mouse models through neutralization of IL-17.
 Journal of dermatological science (Takaishi M, Ishizaki M, Suzuki K, Isobe T, Shimozato T, Sano S) 85/1, 44184 201701 () 10.1016/j.jdermsci.2016.10.001

Pityriasis Rubra Pilaris Type V as an Autoinflammatory Disease by CARD14 Mutations.
 JAMA dermatology (Takeichi T, Sugiura K, Nomura T, Sakamoto T, Ogawa Y, Oiso N, Futei Y, Fujisaki A, Koizumi A, Aoyama Y, Nakajima K, Hatano Y, Hayashi K, Ishida-Yamamoto A, Fujiwara S, Sano S, Iwatsuki K, Kawada A, Suga Y, Shimizu H, McGrath JA, Akiyama M) 153/1, 66-70 201701 () 10.1001/jamadermatol.2016.3601

Epidemiological analysis of psoriatic arthritis patients in Japan.
 The Journal of dermatology (Yamamoto T, Ohtsuki M, Sano S, Igarashi A, Morita A, Okuyama R, Kawada A, Working Group of the Epidemiological Survey in the Japanese Society for Psoriasis Research.) 43/10, 1193-1196 201610 () 10.1111/1346-8138.13342

High load of Merkel cell polyomavirus DNA detected in the normal skin of Japanese patients with Merkel cell carcinoma.
 Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology (Hashida Y, Nakajima K, Nakajima H, Shiga T, Tanaka M, Murakami M, Matsuzaki S, Naganuma S, Kuroda N, Seki Y, Katano H, Sano S, Daibata M) 82/, 101-107 201609 () 10.1016/j.jcv.2016.07.011

Detection of asymptomatic enthesitis in psoriasis patients: An onset of psoriatic arthritis?
 The Journal of dermatology (Takata T, Takahashi A, Taniguchi Y, Terada Y, Sano S) 43/6, 650-654 201606 () 10.1111/1346-8138.13212

Ecology of Merkel Cell Polyomavirus in Healthy Skin Among Individuals in an Asian Cohort.
 The Journal of infectious diseases (Hashida Y, Kamioka M, Tanaka M, Hosokawa S, Murakami M, Nakajima K, Kikuchi H, Fujieda M, Sano S, Daibata M) 213/11, 1708-1716 201606 () 10.1093/infdis/jiw040

Guanosine and its modified derivatives are endogenous ligands for TLR7.
 International immunology (Shibata T, Ohto U, Nomura S, Kibata K, Motoi Y, Zhang Y, Murakami Y, Fukui R, Ishimoto T, Sano S, Ito T, Shimizu T, Miyake K) 28/5, 211-222 201605 () 10.1093/intimm/dxv062

Atypical pemphigus with immunoglobulin G autoantibodies against desmoglein 3 and desmocollin 3.
 The Journal of dermatology (Kamiya K, Aoyama Y, Wakashima C, Kudo T, Nakajima K, Sano S, Ishii N, Teye K, Hashimoto T, Iwatsuki K, Tokura Y) 43/4, 429-431 201604 () 10.1111/1346-8138.13086

Spontaneous remission of aleukemic cutaneous myeloid sarcoma followed by crisis of acute monoblastic leukemia.
 The Journal of dermatology (Takahashi A, Nakajima K, Togitani K, Aoki N, Miyoshi K, Sano S) 43/4, 452-453 201604 () 10.1111/1346-8138.13202

Mesenchymal to Epithelial Transition Induced by Reprogramming Factors Attenuates the Malignancy of Cancer Cells.
 PloS one (Takaishi M, Tarutani M, Takeda J, Sano S) 11/6, e0156904 2016 () 10.1371/journal.pone.0156904

Primary cutaneous adenoid cystic carcinoma arising from folliculitis decalvans.
 The Journal of dermatology (Nakajima H, Matsushima T, Sano S) 42/7, 741-743 201507 () 10.1111/1346-8138.12880

Merkel cell carcinoma showing regression after biopsy: Evaluation of programmed cell death 1-positive cells.
 The Journal of dermatology (Fujimoto N, Nakanishi G, Kabuto M, Nakano T, Eto H, Nakajima H, Sano S, Tanaka T) 42/5, 496-499 201505 () 10.1111/1346-8138.12805

Psoriatic inflammation facilitates the onset of arthritis in a mouse model.
 The Journal of investigative dermatology (Yamamoto M, Nakajima K, Takaishi M, Kitaba S, Magata Y, Kataoka S, Sano S) 135/2, 445-453 201502 () 10.1038/jid.2014.426

Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases.
 Nature communications (Kanno A, Tanimura N, Ishizaki M, Ohko K, Motoi Y, Onji M, Fukui R, Shimozato T, Yamamoto K, Shibata T, Sano S, Sugahara-Tobinai A, Takai T, Ohto U, Shimizu T, Saitoh S, Miyake K) 6/, 6119 201502 () 10.1038/ncomms7119

TNF inhibitors directly target Th17 cells via attenuation of autonomous TNF/TNFR2 signalling in psoriasis.
 Journal of dermatological science (Shiga T, Sato K, Kataoka S, Sano S) 77/1, 79-81 201501 () 10.1016/j.jdermsci.2014.11.008

Correction: involvement of TNF-α converting enzyme in the development of psoriasis-like lesions in a mouse model.
 PloS one (Sato K, Takaishi M, Tokuoka S, Sano S) 10/4, e0124989 2015 () 10.1371/journal.pone.0124989

Downregulation of MHC-I expression is prevalent but reversible in Merkel cell carcinoma.
 Cancer immunology research (Paulson KG, Tegeder A, Willmes C, Iyer JG, Afanasiev OK, Schrama D, Koba S, Thibodeau R, Nagase K, Simonson WT, Seo A, Koelle DM, Madeleine M, Bhatia S, Nakajima H, Sano S, Hardwick JS, Disis ML, Cleary MA, Becker JC, Nghiem P) 2/11, 1071-1079 201411 () 10.1158/2326-6066.CIR-14-0005

Successful treatment of Schnitzler syndrome with cyclosporine.
 International journal of dermatology (Nakajima K, Takahashi M, Yamamoto M, Takahashi A, Sano S, Kodama H, Arima K, Ida H) 53/7, e361-3 201407 () 10.1111/ijd.12300

A case of anti-BP180 type mucous membrane pemphigoid treated with intravenous immunoglobulin.
 The Journal of dermatology (Aoki N, Nakajima K, Shiga T, Koga H, Hashimoto T, Sano S) 41/6, 557-559 201406 () 10.1111/1346-8138.12502

A typical case of paraneoplastic pemphigus without detection of malignancy: effectiveness of plasma exchange.
 Acta dermato-venereologica (Kitagawa C, Nakajima K, Aoyama Y, Fujioka A, Nakajima H, Tarutani M, Tsuruta D, Hashimoto T, Sano S) 94/3, 359-361 201405 () 10.2340/00015555-1742

CD8? tumor-infiltrating lymphocytes at primary sites as a possible prognostic factor of cutaneous angiosarcoma.
 International journal of cancer (Fujii H, Arakawa A, Utsumi D, Sumiyoshi S, Yamamoto Y, Kitoh A, Ono M, Matsumura Y, Kato M, Konishi K, Shiga T, Sano S, Sakaguchi S, Miyagawa-Hayashino A, Takahashi K, Uezato H, Miyachi Y, Tanioka M) 134/10, 2393-2402 201405 () 10.1002/ijc.28581

Psoriasis-like skin lesions are dependent on IL-23 but develop in the absence of IL-22 in a model mouse.
 Journal of dermatological science (Takaishi M, Nakajima K, Ouyang W, Sano S) 73/3, 261-264 201403 () 10.1016/j.jdermsci.2013.11.008

Epicutaneous application of toll-like receptor 7 agonists leads to systemic autoimmunity in wild-type mice: a new model of systemic Lupus erythematosus.
 Arthritis & rheumatology (Hoboken, N.J.) (Yokogawa M, Takaishi M, Nakajima K, Kamijima R, Fujimoto C, Kataoka S, Terada Y, Sano S) 66/3, 694-706 201403 () 10.1002/art.38298

Effective treatment of metastatic renal cell carcinoma with topical imiquimod therapy.
 Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG (Okino T, Fujioka A, Nakajima H, Tarutani M, Shuin T, Sano S) 12/2, 155-157 201402 () 10.1111/ddg.12221

LRIG1 inhibits STAT3-dependent inflammation to maintain corneal homeostasis.
 The Journal of clinical investigation (Nakamura T, Hamuro J, Takaishi M, Simmons S, Maruyama K, Zaffalon A, Bentley AJ, Kawasaki S, Nagata-Takaoka M, Fullwood NJ, Itami S, Sano S, Ishii M, Barrandon Y, Kinoshita S) 124/1, 385-397 201401 () 10.1172/JCI71488

Involvement of TNF-α converting enzyme in the development of psoriasis-like lesions in a mouse model.
 PloS one (Sato K, Takaishi M, Tokuoka S, Sano S) 9/11, e112408 2014 () 10.1371/journal.pone.0112408

Effective therapy with proton irradiation for oral melanoma.
 The Journal of dermatology (Okino T, Nakajima H, Tarutani M, Kiyohara Y, Murayama S, Sano S) 40/11, 945-946 201311 () 10.1111/1346-8138.12291

Dystrophic epidermolysis bullosa pruriginosa in a mother and daughter successfully treated by low dose cyclosporine.
 European journal of dermatology : EJD (Tarutani M, Shiga T, Nakajima K, Nakano H, Sawamura D, Sano S) 23/5, 727-729 201309 () 10.1684/ejd.2013.2126

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■ 研究業績(口頭・ポスター)

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