ATP-sensitive K+ (KATP) channels couple cellular electrical activity to cytosolic metabolic status in various excitable tissues. These channels are widely expressed in central neurons, and we have recently identified and characterized KATP channels in primary afferent neurons. These currents are diminished in large myelinated neuronal somata from rats with painful nerve injury, and this loss contributes to neuropathic pain by increasing membrane excitability and neurotransmitter release. In addition, intrinsic single-KATP channel characteristics and its pharmacological property are preserved even after painful nerve injury. Therefore, KATP channels in primary afferent neurons warrant further investigation as putative therapeutic targets against peripheral neuropathic pain.
Repeated intra-articular injections of acidic saline produce long-lasting joint pain and widespread hyperalgesia
Eur J Pain (Sugimura N, Ikeuchi M, Izumi M, Kawano T, Aso K, Kato T, Ushida T, Yokoyama M, Tani T) /, 2014 (学術雑誌)
Prolonged post-dural puncture headache in a patient during treatment with selective serotonin reuptake inhibitor: a case report and animal experiment.
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A preliminary study of patients' perceptions on the implementation of the WHO surgical safety checklist in women who had Cesarean sections.
J Anesth (Kawano T, Tani M, Taniwaki M, Ogata K, Yokoyama M.) 29/3, 459-62 2015 (学術雑誌) 10.1007/s00540-014-1934-3
Effects of dexmedetomidine on insulin secretion from rat pancreatic β cells.
J Anesth (Takahashi T, Kawano T, Eguchi S, Chi H, Iwata H, Yokoyama M.) 29/3, 396-402 2015 (学術雑誌) 10.1007/s00540-014-1943-2
A comparison of midazolam and dexmedetomidine for the recovery of serotonin syndrome in rats.