■ 氏名
上羽 哲也 (ウエバ テツヤ)
UEBA Tetsuya

■ 所属部局/職名
Research and Education Faculty, Medical Sciences Cluster, Clinical Medicine Unit/Professor
教育研究部 医療学系 臨床医学部門/教授

■ 学部・学科・コース等
Medical School, Medical Course, Department of Neurosurgery
医学部 医学科 脳神経外科学

■ 連絡先
住 所
電 話
F A X
E-Mail
U R L

■ 出身大学院・研究科等

■ 出身学校・専攻等

■ 取得学位
博士(医学) () 京都大学
医学士 () 京都大学

■ 研究職歴

■ 委員歴・役員歴

■ 受賞学術賞

■ 所属学会

■ 専門分野

■ 主な研究テーマ・活動

■ 研究についてのPR

■ 社会人・生徒を対象として可能な講演・授業(例えば講演題目)

■ 研究業績(論文・解説)
A randomized, double-blind, phase III trial of personalized peptide vaccination for recurrent glioblastoma.
 Neuro Oncol. (Narita Y, Arakawa Y, Yamasaki F, Nishikawa R, Aoki T, Kanamori M, Nagane M, Kumabe T, Hirose Y, Ichikawa T, Kobayashi H, Fujimaki T, Goto H, Takeshima H, Ueba T, Abe H, Tamiya T, Sonoda Y, Natsume A, Kakuma T, Sugita Y, Komatsu N, Yamada A, Sasada T, Matsueda S, Shichijo S, Itoh K, Terasaki M.) /, 201811 ()

Attenuation of zinc-enhanced inflammatory M1 phenotype of microglia by peridinin protects against short-term spatial-memory impairment following cerebral ischemia in mice.
 Biochem Biophys Res Commun. (Ueba Y, Aratake T, Onodera KI, Higashi Y, Hamada T, Shimizu T, Shimizu S, Yawata T, Nakamura R, Akizawa T, Ueba T, Saito M.) 507/, 476-483 2018 ()

The inhibitory role of intracellular free zinc in the regulation of Arg-1 expression in interleukin-4-induced activation of M2 microglia.
 Metallomics. (Aratake T, Higashi Y, Ueba Y, Hamada T, Shimizu T, Shimizu S, Yawata T, Ueba T, Saito M.) 10/, 1501-1509 2018 ()

Stimulation of brain nicotinic acetylcholine receptors activates adrenomedullary outflow via brain inducible NO synthase-mediated S-nitrosylation.
 Br J Pharmacol. (Higashi Y, Shimizu T, Yamamoto M, Tanaka K, Yawata T, Shimizu S, Zou S, Ueba T, Yuri K, Saito M.) 175/, 3758-3772 2018 ()

Remote effects in the ipsilateral thalamus and/or contralateral cerebellar hemisphere using FDG PET in patients with brain tumors.
 Jpn J Radiol. (Iwasa H, Murata Y, Nishimori M, Miyatake K, Tadokoro M, Kohsaki S, Nogami M, Ueba Y, Ueba T, Yamagami T.) 36/, 301-311 2018 ()

Influence of extracellular zinc on M1 microglial activation.
 Sci Rep (Higashi Y, Aratake T, Shimizu S, Shimizu T, Nakamura K, Tsuda M, Yawata T, Ueba T, Saito M: Influence of extracellular zinc on M1 microglial activation.) 7/, 43778 2017 ()

Phase I/II Study of Temozolomide Plus Nimustine Chemotherapy for Recurrent Malignant Gliomas: Kyoto Neuro-oncology Group.
 Neurol Med Chir (Tokyo) (Aoki T, Arakawa Y, Ueba T, Oda M, Nishida N, Akiyama Y, Tsukahara T, Iwasaki K, Mikuni N, Miyamoto S) 57/, 17-27 2017 ()

Brain opioid and nociceptin receptors are involved in regulation of bombesin-induced activation of central sympatho-adrenomedullary outflow in the rat.
 Mol Cell Biochem () 411/, 201-211 2016 ()

Nakashima K, Kodama Y, Nishikawa T, Nishimura M, Ito N, Fukano R, Nomura Y, Ueba T, Inoue T, Oshima K, Okamura J, Inagaki J
 Pediatr Int, () 58/, 388-390 2016 ()

Use of fat-suppressed T2 -weighted sagittal images after infusion of excess saline into the subarachnoid space as a new diagnostic modality for cerebrospinal fluid hypovolemia: technical note.
 J Neurosurg. () 124/, 580-583 2016 ()

A direct aspiration first pass technique for retrieval of a detached coil.
 BMJ Case Rep. (Masahira N, Ohta T, Fukui N, Yanagawa T, Kondou Y, Morimoto M, Ueba T.) /, 2015 ()

Possible inhibitory role of endogenous 2-arachidonoylglycerol as an endocannabinoid in (±)-epibatidine-induced activation of central adrenomedullary outflow in the rat.
 Neuropharmacol () 95/, 278-289 2015 ()

Prevalence of human cytomegalovirus, polyomaviruses, and oncogenic viruses in glioblastoma among Japanese subjects.
 Infect Agent Cancer () 10/, 3 2015 ()

Elevated cell invasion in a tumor sphere culture of RSV-M mouse glioma cells.
 Neurol Med Chir (Tokyo) () 55/, 60-70 2015 ()

Angiotensin II acting on brain AT1 receptors induces adrenaline secretion and pressor responses in the rat.
 Sci Rep () 4/, 7248 2014 ()

Suppression of oxidative stress and 5-lipoxygenase activation by edaravone improves depressive-like behavior after concussion.
 J Neurotrauma () 31/, 1689-1699 2014 ()

Possible involvement of brain prostaglandin E2 and prostanoid EP3 receptors in prostaglandin E2 glycerol ester-induced activation of central sympathetic outflow in the rat.
 Neuropharmacology () 82/, 19-27 2014 ()

Elevated RANTES level is associated with metabolic syndrome and correlated with activated platelets associated markers in healthy younger men.
 Clin Appl Thromb Hemost () 20/, 813-818 2014 ()

Transdural Imaging of Meningiomas by Indocyanine Green Videography ? The Ec lipse Sign Minim Invasive
 Neurosurg () 74/, 51-53 2013 ()

Feasibility and Safety of Acute Phase Rehabilitation after Stroke Using the Hybrid Assistive Limb Robot Suit.
 Neurol Med Chir (Tokyo) () 53/, 287-290 2013 ()

Safety and Feasibility of Combined Coiling and Neuroendoscopy for Better Outcomes in the Treatment of Severe Subarachnoid Hemorrhage with Massive Intraventricular Hemorrhage.
 J Clin Neurosci. () 20/, 1264-1268 2013 ()

Identification of Venous Sinus, Tumor Location, and Pial Supply During Meningioma Surgery by Transdural Indocyanine Green Videography.
 J Neurosurg () 118/, 632-636 2013 ()

Long-term Mobility and Mortality of Carotid Endarterectomy in Patients with End-stage Renal Disease Receiving Hemodialysis.
 J Stroke Cerebrovasc Dis () S1052-3057(13)00179-1/, 2013 ()

Posterior Circulation Hyperperfusion Syndrome after Superficial Temporal Artery-Superior Cerebellar Artery Bypass for Vertebral Artery Dissection.
 J Stroke Cerebrovasc Dis () S1052-3057(13)00165-1/, 2013 ()

Hemifacial spasm caused by a dissecting aneurysm of the vertebral artery, and resulting in acute exacerbation.
 脳神経外科 () 41/, 241-246 2013 ()

Quantitative evaluation using the plaque/muscle ratio index panels predicts plaque type and risk of embolism in patients undergoing carotid artery stenting.
 Clin Neurol Neurosurg. () 115/, 1298-1303 2013 ()

Central nervous system marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type involving the brain and spinal cord parenchyma.
 Neuropathology () 33/, 306-311 2013 ()

Efficacy of indocyanine green videography and real-time evaluation by FLOW 800 in the resection of a spinal cord hemangioblastoma in a child
 J Neurosurg Pediatr () 9/, 428-431 2012 ()

Measuring quality of care using quality indicator for infants <3 months old with fever.
 Pediatr Int. () 53/, 412-413 2011 ()

Early detection of metachronous brain metastases by biannual brain MRI follow-up may provide patients with non-small cell lung cancer with more opportunities to have radiosurgery.
 Clin Neurol Neurosurg () 12/, 770-774 2010 ()

Plasma level of platelet-derived microparticles is associated with coronary heart disease risk score in healthy men.
 J Atheroscler Thromb () 17/, 342-349 2010 ()

Correlation and association of plasma interleukin-6 and plasma platelet-derived microparticles, markers of activated platelets, in healthy individuals.
 Thromb Res () 125/, e329-e334 2010 ()

Phase II study of ifosfamide, carboplatin, and etoposide in patients with a first recurrence of glioblastoma multiforme.
 J Neurosurg () 12/, 50-56 2010 ()

Effects of eicosapentaenoic acid on endothelial cell-derived microparticles, angiopoietins and adiponectin in patients with type 2 diabetes.
  J Atheroscler Thromb () 16/, 83-90 2009 ()

A priority treatment of the intraventricular hemorrhage (IVH) should be performed in the patients suffering intracerebral hemorrhage with large IVH.
 Clin Neurol Neurosurg () 111/, 450-453 2009 ()

Cerebral microbleeds predict first-ever symptomatic cerebrovascular events.
 Clin Neurol Neurosurg () 111/, 825-828 2009 ()

Circulating oxidized LDL, measured with FOH1a/DLH3 antibody, is associated with metabolic syndrome and the coronary heart disease risk score in healthy Japanese.
 Atherosclerosis () 203/, 243-248 2009 ()

A dyad symmetry element in the fibroblast growth factor-2 gene promoter with different levels of activity in astrocytoma and hepatocelluar carcinoma cell lines.
 J Neurooncol () 78/, 107-111 2006 ()

Overexpression of RFT induces G1-S arrest and apoptosis via p53/p21(Waf1) pathway in glioma cell.
 Biochem Biophys Res Commun () 317/, 902-908 2004 ()

High expression of Aurora-B/Aurora and Ipll-like midbody-associated protein (AIM-1) in astrocytomas.
 J Neurooncol () 67/, 53-64 2004 ()

MRI and CT findings of neurohypophyseal germinoma.
 Eur J Radiol. () 49/, 204-211 2004 ()

The combination of mitotic and Ki-67 indices as a useful method for predicting short-term recurrence of meningiomas.
 Surg Neurol. () 61/, 149-155 2004 ()

Liliequist membrane: three-dimensional constructive interference in steady state MR imaging.
 Radiology () 229/, 360-365 2003 ()

In vitro growth suppression of human glioma cells by a 16-mer oligopeptide: a potential new treatment modality for malignant glioma.
 J Neurooncol () 63/, 163-171 2003 ()

Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function.
 Proc Natl Acad Sci U S A () 100/, 6777-6782 2003 ()

Effects of combination chemotherapy with biscoclaurine-derived alkaloid (Cepharanthine) and nimustine hydrochloride on malignant glioma cell lines.
 J Neurooncol () 56/, 101-108 2002 ()

Venous congestion is a major cause of neurological deterioration in spinal arteriovenous malformations.
 Neurosurgery () 48/, 1224-1229 2001 ()

Apoptosis of human glioma cells in vitro and in vivo induced by a neutralizing antibody against human basic fibroblast growth factor.
 J Neurosurg. () 85/, 1072-1077 1996 ()

Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells.
 Proc Natl Acad Sci U S A () 91/, 9009-9013 1994 ()

Expression of fibroblast growth factor receptor-1 in human glioma and meningioma tissues.
 Neurosurgery () 34/, 221-225 1994 ()

Primary malignant lymphoma in the sphenoid sinus with orbital apex syndrome; a case report
 No Shinkei Geka. () 20/, 283-287 1992 ()

■ 研究業績(著書)
日本臨床74巻増刊号7別冊 脳腫瘍学-基礎研究と臨床研究の進歩-(2016)
 出版社:日本臨床社

■ 研究業績(口頭・ポスター)
水頭症を合併した脊髄血管芽腫の1歳女児例 (第465回日本小児科学会福岡地方会 2011 ポスター)

■ 研究業績(特許)

■ 研究業績(その他の活動)


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