■ 氏名
齋藤 源顕 (サイトウ モトアキ)
SAITO Motoaki

■ 所属部局/職名
Research and Education Faculty, Medical Sciences Cluster, Basic Medicine Unit/Professor
教育研究部 医療学系 基礎医学部門/教授

■ 学部・学科・コース等
Medical School, Medical Course, Department of Pharmacology
医学部 医学科 薬理学

■ 連絡先
住 所
電 話22620
F A X088-880-2325
E-Mailsaitomo●kochi-u.ac.jp    (送信の際は“●”を半角の“@”に変更して送信してください。)
U R Lhttp://www.kochi-ms.ac.jp/~ff_phrmc/index.html

■ 出身大学院・研究科等

■ 出身学校・専攻等
鳥取大学 (医学部 医学科) 1991 (卒業)

■ 取得学位
医学博士 (論文) 鳥取大学 泌尿器科学

■ 研究職歴
米国イェール大学医学部泌尿器科Postdoctoral Associate
1993年3月より1996年10月まで

■ 委員歴・役員歴

■ 受賞学術賞
第8回日本排尿機能学会学会賞受賞 (平成13年)
第7回ギリシャ・アンドロロジー学会学会賞受賞 (平成18年) 国外
平成18年度鳥取大学科学研究業績表彰(日ノ丸賞)受賞 (平成19年)
第98回日本泌尿器科学会総会賞受賞 (平成22年)
平成22年度鳥取大学長表彰: 研究功績賞受賞 (平成23年)
International Journal of Urology Reviewer of the Year 2011 受賞 (平成24年) 国外
第23回日本性機能学会学術総会賞受賞 (平成24年)
International Journal of Urology Reviewer of the Year 2012 受賞 (平成25年) 国外

■ 所属学会
日本泌尿器科学会
 ( 国内)
米国泌尿器科学会
 ( 国外)
国際禁制学会
 ( 国外)
日本排尿機能学会
 ( 国内)
日本性機能学会
 ( 国内)
日本薬理学会
 (学術評議員 国内)

■ 専門分野
下部尿路平滑筋の薬理学
排尿障害
勃起障害

■ 主な研究テーマ・活動
1. 糖尿病時の尿路生殖器におけるエンドセリン受容体の発現に関する研究
2. 膀胱機能と血流に関する研究
3. 尿路生殖器の虚血−再灌流に関する研究
4. 糖尿病および高血圧とEDに関する研究
5. 新規治療薬N-hexacosanolの開発
6. 難治性過活動膀胱に対するハイドロキシプロピルセルロースを配合したオキシブチニン膀胱内注入療法の開発
7. ロキソプロフェンの夜間頻尿改善効果に関する研究


■ 研究についてのPR
薬理学の究極の目標は薬の臨床応用ですが、今日の生命科学の飛躍的な発展により、再生医療も含め、様々な医学研究の可能性が見いだされています。従って、基礎医学と臨床医学の橋渡しとなる研究の必要性は高まっています。薬理学は応用科学・治療学の側面があり、これまでの基礎的研究成果を臨床に結びつける探索的研究に最も近い生命科学分野の1つであると考えています。実際の研究テーマの設定に当たっては、研究者個人が興味を持ち、なおかつ「すでに流行になっている研究の発展ではなく、源流となる研究」を目指します。そのためには従来の薬理学的および分子生物学的研究方法に加え、最先端の手技・手法を実施できる環境をつくり、若い研究者の斬新な発想に対応していきたいと考えています。研究仮説の証明には、多角的な視点からの検討が必要です。学内での共同研究を基盤に国際的共同研究、県や県内の施設の支援を相互に高めた共同研究や産学連携研究を積極的に推進するとともに、さらには大学をあげた共同研究についても積極的に行いたいと考えています。


■ 社会人・生徒を対象として可能な講演・授業(例えば講演題目)

■ 研究業績(論文・解説)
Renal cell carcinoma associated with hypercalcaemia
 Br J Urol (Saito M, Miyagawa I, Nakamura I, Nemoto R) 78/, 135 1996 (学術雑誌)

Subtype specificity of muscarinic receptors in different regions of rabbit urinary tract
 Neurourol Urodyn (Saito M, Latifpour J, Mutoh S, Nishi K, Miyagawa I, Weiss RM) 15/, 311-313 1996 (学術雑誌)

Characterization of endothelin receptors in streptozotocin-induced diabetic rat vas deferens
 Biochem Pharmacol (Saito M, Nishi K, Fukumoto Y, Weiss RM, Latifpour J) 52/, 1593-1598 1996 (学術雑誌)

Effect of experimental diabetes on rat prostate endothelin receptors
 Eur J Pharmacol (Saito M, Nishi K, Foster HE Jr, Weiss RM, Latifpour J) 310/, 197-200 1996 (学術雑誌)

Endothelin receptors in diabetic rat bladder dome
 Neurourol Urodyn (Saito M, Foster HE Jr, Wada Y, Miyagawa I, Weiss RM, Latifpour J) 16/, 373-374 1997 (学術雑誌)

Experimental diabetes upregulates the expression of ureteral endothelin receptors
 Peptides (Nakamura I, Saito M, Fukumoto Y, Yoshida M, Nishi K, Weiss RM, Latifpour J) 18/, 1091-1093 1997 (学術雑誌)

Evidence for the presence of regional differences in the subtype specificity of muscarinic receptors in rabbit lower urinary tract
 J Urol (Mutoh S, Latifpour J, Saito M, Weiss RM) 157/, 717-721 1997 (学術雑誌)

Micturitional disturbances due to labial adhesion
 Urol Int (Saito M, Ishida G, Watanabe N, Abe B) 61/, 50-51 1998 (学術雑誌)

Nitric oxide in ischemia-reperfusion rat bladder
 Neurourol Urodyn (Saito M, Miyagawa I) 17/, 409-410 1998 (学術雑誌)

Effect of ischemia-reperfusion on contractile function of rat urinary bladder: possible role of nitric oxide
 Life Sci (Saito M, Wada K, Kamisaki Y, Miyagawa I) 62/, PL149-PL156 1998 (学術雑誌)

Characterization, localization and distribution of alpha1 adrenoceptor subtype in male rabbit urethra
 J Urol (Nishi K, Latifpour J, Saito M, Foster HE Jr, Yoshida M, Weiss RM) 160/, 196-205 1998 (学術雑誌)

Inflammatory pseudotumor of the urinary bladder and sigmoid colon
 Urol Int (Saito M, Watanabe N, Abe B, Matsui A) 62/, 119-121 1999 (学術雑誌)

Bladder dysfunction in acute urinary retention and subsequent catheterization
 Neurourol Urodyn (Saito M, Miyagawa I) 19/355-356, 1999 (学術雑誌)

Effects of insulin treatment on diabetes-induced alterations in endothelin receptors in rat ureter
 Int J Urol (Saito M, Weiss RM, Latifpour J) 6/, 361-368 1999 (学術雑誌)

Direct detection of nitric oxide in rat urinary bladder during ischemia-reperfusion
 J Urol (Saito M, Miyagawa I) 162/, 1490-1495 1999 (学術雑誌)

Bladder dysfunction due to Behçet’s disease
 Urol Int (Saito M, Miyagawa I) 65/, 40-42 2000 (学術雑誌)

Bladder dysfunction in acute urinary retention and subsequent catheterization
 Neurourol Urodyn (Saito M, Miyagawa I) 19/, 434-435 2000 (学術雑誌)

Developmental aspects of endothelin receptors in rabbit lower urinary tract
 Neurourol Urodyn (Saito M, Latifpour J, Weiss RM) 19/, 71-85 2000 (学術雑誌)

Gene expression, localization, and pharmacological characterization of endothelin receptors in diabetic rat bladder dome
 Eur J Pharmacol (Saito M, Wada Y, Ikeda K, Wang Z, Smith SD, Foster HE Jr, Nishi K, Weiss RM, Latifpour J) 387/, 253-263 2000 (学術雑誌)

Real-time monitoring of nitric oxide in ischemia-reperfusion rat kidney
 Urol Res (Saito M, Miyagawa I) 28/, 141-146 2000 (学術雑誌)

Expression of endothelin receptor subtypes and their messenger RNAs in diabetic rat prostate: effect of insulin treatment
 Mol Cell Biochem (Saito M, Wada Y, Ikeda K, Wang Z, Foster HE Jr, Smith SD, Weiss RM, Latifpour J) 210/, 1-12 2000 (学術雑誌)

Age-related changes in contractile responses of rabbit lower urinary tract to endothelin
 J Urol (Wada Y, Latifpour J, Sanematsu H, Afiatpour P, Wang Z, Saito M, Nishi K, Weiss RM) 164/, 806-813 2000 (学術雑誌)

A simple technique to change an obstructed ureteral stent in patients with an ileal conduit
 J Urol (Saito M, Sakaridani N, Yamamoto Y, Miyagawa I) 164/, 1604-1605 2000 (学術雑誌)

Treatment of overactive bladder with modified intravesical oxybutynin chloride
 Neurourol Urodyn (Saito M, Tabuchi F, Otsubo K, Miyagawa I) 19/, 683-688 2000 (学術雑誌)

Acute renal failure associated with sulfur calculi
 J Urol (Saito M, Takahashi C, Ishida G, Kadowaki H, Hirakawa S, Miyagawa I) 165/, 1985-1986 2001 (学術雑誌)

NOS inhibitors prevent apoptosis induced by ischemia-reperfusion in the rat bladder
 Neurourol Urodyn (Saito M, Miyagawa I) 20/, 478-479 2001 (学術雑誌)

Bladder dysfunction after acute urinary retention in rats
 J Urol (Saito M, Miyagawa I) 165/, 1745-1747 2001 (学術雑誌)

Developmental changes in the biochemical and functional properties of endothelin receptors in rabbit renal pelvis
 BJU Int (Wada Y, Latifpour J, Saito M, Afiatpour P, Weiss RM) 88/, 950-959 2001 (学術雑誌)

Editorial Comment to H+-K+ ATPase inhibitors induce relaxation on rabbit prostatic strips in vitro
 Int J Urol (Saito M) 9/, 645 2002 (学術雑誌)

N(G)-nitro-L-arginine methylester, a nitric oxide synthase inhibitor, diminishes apoptosis induced by ischemia-reperfusion in the rat bladder
 Neurourol Urodyn (Saito M, Miyagawa I) 21/, 566-571 2002 (学術雑誌)

Preventive effect of long-chain fatty alcohol on ischemia-reperfusion injury in the rat bladder
 Eur J Pharmacol (Saito M, Suzuki H, Yamada M, Miyagawa I) 454/, 81-84 2002 (学術雑誌)

Expression of heat shock protein 70 and its mRNAs during ischemia-reperfusion in the rat prostate
 Eur J Pharmacol (Saito M, Tominaga L, Nanba E, Miyagawa I) 487/, 199-203 2004 (学術雑誌)

Expression of HSP 70 and its mRNAs during ischemia-reperfusion in the rat bladder
 Life Sci (Saito M, Tominaga L, Nanba E, Kinoshita Y, Houri D, Miyagawa I, Satoh K) 75/, 1879-1886 2004 (学術雑誌)

Urodynamic effects and safety of modified intravesical oxybutynin chloride in patients with neurogenic detrusor overactivity: 3 years experience
 Int J Urol (Saito M, Watanabe T, Tabuchi F, Otsubo K, Satoh K, Miyagawa I) 11/, 592-596 2004 (学術雑誌)

Demonstration of bladder selective muscarinic receptor binding by intravesical oxybutynin to treat overactive bladder
 J Urol (Oki T, Kimura R, Saito M, Miyagawa I, Yamada S) 172/, 2059-2064 2004 (学術雑誌)

Effect of cyclohexenonic long-chain fatty alcohol on rat overactive bladder induced by bladder neck obstruction
 Eur J Pharmacol (Saito M, Suzuki H, Yamada M, Hikita K, Kobayashi N, Kinoshita Y, Houri D, Miyagawa I, Satoh K) 501/, 143-149 2004 (学術雑誌)

Benign fibrous ureteral polyp found by ultrasonography in medical examination
 Hellenic Urol (Saito M, Takeda N) 17/, 301-303 2005 (学術雑誌)

Fibroepithelial polyp of distal ureter with periodic prolapse into bladder
 Urol Int (Baltogiannis D, Kafetsoulis A, Giannakis D, Saito M, Miyagawa I, Sofikitis N) 80/, 338-340 2005 (学術雑誌)

Loxoprofen inhibits facilitated micturition reflex induced by acetic acid urinary bladder infusion of the rats
 Biomed Res (Shinozaki S, Saito M, Kawatani M) 26/, 29-33 2005 (学術雑誌)

Effects of cyclohexenonic long-chain fatty alcohol on diabetic rat trachea
 Life Sci (Satoh I, Saito M, Kinoshita Y, Shomori K, Suzuki H, Yamada M, Kono T, Satoh K) 77/, 2030-2039 2005 (学術雑誌)

Effectiveness of an anti-inflammatory drug, loxoprofen, for patients with nocturia
 Int J Urol (Saito M, Kawatani M, Kinoshita Y, Satoh K, Miyagawa I) 12/, 779-782 2005 (学術雑誌)

Preventive effects of cyclohexenonic long-chain fatty alcohol on diabetic cystopathy in the rat
 Can J Physiol Pharmacol (Suzuki H, Saito M, Kinoshita Y, Satoh I, Kono T, Shinbori C, Anastasios S, Yamada M, Satoh K) 84/, 195-201 2005 (学術雑誌)

Genetic and epigenetic risks of intracytoplasmic sperm injection method
 Asian J Androl (Georgiou I, Syrrou M, Pardalidis N, Karakitsios K, Mantzavinos T, Giotitsas N, Loutradis D, Dimitriadis F, Saito M, Miyagawa I, Tzoumis P, Sylakos A, Kanakas N, Moustakareas T, Baltogiannis D, Touloupides S, Giannakis D, Fatouros M, Sofikitis N) 39/, 159-176 2006 (学術雑誌)

General administration of cyclohexenonic long-chain fatty alcohol ameliorates hyperreactivity of STZ-induced diabetic rat aorta
 Life Sci (Kinoshita Y, Saito M, Satoh I, Shomori K, Suzuki H, Yamada M, Kono T, Satoh K) 78/, 1508-1514 2006 (学術雑誌)

Real-time monitoring of nitric oxide and blood flow during ischemia-reperfusion in the rat testis
 Mol Cell Biochem (Kono T, Saito M, Kinoshita Y, Satoh I, Shinbori C, Satoh K) 78/, 1508-1514 2006 (学術雑誌)

N-hexacosanol ameliorates streptozotocin-induced diabetic rat nephropathy
 Eur J Pharmacol (Saito M, Kinoshita Y, Satoh I, Shinbori C, Kono T, Hanada T, Uemasu J, Suzuki H, Yamada M, Satoh K) 544/, 132-137 2006 (学術雑誌)

N-hexacosanol reverses diabetic induced muscarinic hypercontractility of ileum in the rat
 Eur J Pharmacol (Shinbori C, Saito M, Kinoshita Y, Satoh I, Kono T, Hanada T, Nanba E, Adachi K, Suzuki H, Yamada M, Satoh K) 545/, 177-184 2006 (学術雑誌)

Treatment with cyclohexenonic long-chain fatty alcohol reverses diabetes-induced tracheal dysfunction in the rat
 Pharmacology (Hanada T, Saito M, Kanzaki S) 78/, 51-60 2006 (学術雑誌)

In vitro spermatogenesis as a method to bypass pre-meiotic or post-meiotic barriers blocking the spermatogenetic process: genetic and epigenetic implications in assisted reproductive technology
 Andrologia (Georgiou I, Pardalidis N, Giannakis D, Saito M, Watanabe T, Tsounapi P, Loutradis D, Kanakas N, Karagiannis A, Baltogiannis D, Giotitsas N, Miyagawa I, Sofikitis N) 39/, 159-176 2007 (学術雑誌)

Ability of cyclohexenonic long-chain fatty alcohol to reverse diabetes-induced cystopathy in the rat
 Eur Urol (Saito M, Kinoshita Y, Satoh I, Shinbori C, Suzuki H, Yamada M, Watanabe T, Satoh K) 51/, 479-488 2007 (学術雑誌)

Cyclohexenonic long-chain fatty alcohol has therapeutic effects on diabetes- induced angiopathy in the rat aorta
 Eur J Pharmacol (Shinbori C, Saito M, Kinoshita Y, Satoh I, Kono T, Hanada T, Nanba E, Adachi K, Suzuki H, Yamada M, Satoh K) 567/, 139-144 2007 (学術雑誌)

Beneficial effect of preconditioning on ischemia-reperfusion injury in the rat bladder in vivo
 Life Sci (Hisadome Y, Saito M, Kono T, Satoh I, Kinoshita Y, Satoh K) 81/, 347-352 2007 (学術雑誌)

Treatment with modified intravesical oxybutynin chloride for neurogenic bladder in children
 J Pediatr Urol (Hayashi A, Saito M, Okada S, Hanada T, Watanabe T, Satoh K, Kanzaki S) 3/, 438-442 2007 (学術雑誌)

N-hexacosanol prevents diabetes-induced rat ileal dysfunction without qualitative alteration of the muscarinic receptor system
 Biomed Res (Narimatsu N, Saito M, Kazuyama E, Hisadome Y, Kinoshita Y, Satoh I, Okada S, Suzuki H, Yamada M, Satoh K) 28/, 267-273 2007 (学術雑誌)

Effects of phosphodiesterase-5 inhibitors on sperm parameters and fertilizing capacity
 Asian J Androl (Dimitriadis F, Giannakis D, Pardalidis N, Zikopoulos K, Paraskevaidis E, Giotitsas N, Kalaboki V, Tsounapi P, Baltogiannis D, Georgiou I, Saito M, Watanabe T, Miyagawa I, Sofikitis N) 10/, 115-133 2008 (学術雑誌)

Ability of cyclohexenonic long-chain fatty alcohol to ameliorate diabetes-induced cystopathy in the rat
 Pharmacology (Kazuyama E, Saito M, Okada S, Satoh K) 81/, 137-143 2008 (学術雑誌)

Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia- reperfusion injury in the rat bladder
 Mol Cell Biochem (Kono T, Okada S, Saito M) 311/, 87-92 2008 (学術雑誌)

Effects of cyclohexanonic long-chain fatty alcohol, tCFA15 on amino acids in diabetic rat brain: a preliminary study
 Neurochem Res (Shinbori C, Shirayama Y, Mitani H, Saito M, Satoh K) 33/, 1189-1195 2008 (学術雑誌)

Effects of N-hexacosanol on nitric oxide synthase system in diabetic rat nephropathy
 Mol Cell Biochem (Okada S, Saito M, Kazuyama E, Hanada T, Kawaba Y, Hayashi A, Satoh K, Kanzaki S) 315/, 169-177 2008 (学術雑誌)

Pharmacological properties, functional alterations and gene expression of muscarinic receptors in young and old type 2 Goto-Kakizaki diabetic rat bladders
 J Urol (Saito M, Okada S, Kazuyama E, Satoh I, Kinoshita Y, Satoh K) 180/, 2701-2705 2008 (学術雑誌)

Is there a role for PDE5 inhibitors in the management of male infertility due to defects in testicular or epididymal function?
 Curr Pharm Des (Dimitriadis F, Tsounapi P, Saito M, Watanabe T, Sylakos A, Tsabalas S, Miyagawa I, Sofikitis N) 15/, 3506-3520 2009 (学術雑誌)

Acute urinary retention and subsequent catheterization cause lipid peroxidation and oxidative DNA damage in the bladder: preventive effect of edaravone, a free- radical scavenger
 BJU Int (Shimizu S, Saito M, Kinoshita Y, Kazuyama E, Tamamura M, Satoh I, Satoh K) 104/, 713-717 2009 (学術雑誌)

Post-fertilization effects of chronic renal failure in male rats
 Int J Androl (Dimitriadis F, Giannakis D, Giotitsas N, Parldalidis N, Baltogiannis D, Saito M, Watanabe T, Gratsias S, Zikopoulos K, Pashopoulos M, Tsambalas S, Kalaboki V, Tsounapi P, Vlachopoulou E, Gekas A, Melekos M, Makridimas G, Dalkalitsis N, Georgiou I, Agapitos E, Loutradis D, Kanakas N, Miyagawa I, Sofikitis N) 32/, 675-686 2009 (学術雑誌)

Characterization of the ileal muscarinic receptor system in 70-week-old type II Goto-Kakizaki diabetic rats; effects of cyclohexenonic long-chain fatty alcohol
 Eur J Pharmacol (Okada S, Saito M, Kinoshita Y, Satoh I, Kazuyama E, Hayashi A, Satoh K, Kanzaki S) 611/, 72-76 2009 (学術雑誌)

Ischemic preconditioning and post-conditioning to decrease testicular torsion- detorsion injury
 J Urol (Shimizu S, Saito M, Kinoshita Y, Shomori K, Satoh I, Satoh K) 182/, 1637-1643 2009 (学術雑誌)

Effects of primary testicular damage on sperm DNA oxidative status and embryonic and foetal development
 Andrologia (Dimitriadis F, Giannakis D, Pardalidis N, Tsoukanelis K, Kanakas N, Saito M, Watanabe T, Miyagawa I, Tsounapi P, Sofikitis N) 41/, 282-296 2009 (学術雑誌)

Endothelial dysfunction in the early- and late-stage type-2 diabetic Goto-Kakizaki rat aorta
 Mol Cell Biochem (Kazuyama E, Saito M, Kinoshita Y, Satoh I, Dimitriadis F, Satoh K) 332/, 95-102 2009 (学術雑誌)

Effect of the rho-kinase inhibitor hydroxyfasudil on bladder overactivity: an experimental rat model
 Int J Urol (Masago T, Watanabe T, Saito M, Kinoshita Y, Satoh K, Miyagawa I) 16/, 842-847 2009 (学術雑誌)

Erectile function and male reproduction in men with spinal cord injury: a review
 Andrologia (Dimitriadis F, Karakitsios K, Tsounapi P, Tsambalas S, Loutradis D, Kanakas N, Watanabe T, Saito M, Miyagawa I, Sofikitis N) 42/, 139-165 2010 (学術雑誌)

Protective effect of edaravone, a free-radical scavenger, on ischemia-reperfusion injury in the rat testis
 BJU Int (Tamamura M, Saito M, Kinoshita Y, Shimizu S, Satoh I, Shomori K, Dimitriadis F, Satoh K) 105/, 870-876 2010 (学術雑誌)

Bladder dysfunction after acute urinary retention in the rats: a novel over active bladder model
 Mol Cell Biochem (Saito M, Shimizu S, Kinoshita Y, Satoh I, Shomori K, Dimitriadis F, Satoh K) 333/, 109-114 2010 (学術雑誌)

Effects of phosphodiesterase-5 inhibitors on Leydig cell secretory function in oligoasthenospermic infertile men: a randomized trial
 BJU Int (Dimitriadis F, Tsambalas S, Tsounapi P, Kawamura H, Vlachopoulou E, Haliasos N, Gratsias S, Watanabe T, Saito M, Miyagawa I, Sofikitis N) 106/, 1181-1185 2010 (学術雑誌)

Experience with injections of botulinum toxin type A into the detrusor muscle
 Aktuelle Urol (Miyagawa I, Watanabe T, Isoyama T, Honda M, Kobayashi N, Hikita K, Saito M, Hirakawa S) 41/, S24-S26 2010 (学術雑誌)

The role of ATP-sensitive potassium channel on acute urinary retention and subsequent catheterization in the rat
 Eur J Pharmacol (Ohmasa F, Saito M, Shimizu S, Taniguchi S, Dimitriadis F, Satoh I, Kinoshita Y, Satoh K) 635/, 194-197 2010 (学術雑誌)

Muscarinic receptors and their mRNAs in type 2 Goto-Kakizaki diabetic rat prostate
 Prostate (Saito M, Kazuyama E, Shimizu S, Dimitriadis F, Kinoshita Y, Masuda E, Yamada S, Satoh K) 70/, 1533-1539 2010 (学術雑誌)

Effects of cyclohexenonic long-chain fatty alcohol in type 2 diabetic rat nephropathy
 Biomed Res (Okada S, Saito M, Kinoshita Y, Satoh I, Kawaba Y, Hayashi A, Oite T, Satoh K, Kanzaki S) 31/, 219-230 2010 (学術雑誌)

A β3 agonist, mirabegron for the treatment of overactive bladder
 UroToday Int J (Saito M, Dimitriadis F, Ohmasa F, Inoue S, Satoh K) 4/, art70 2011 (学術雑誌)

Protective effect of sivelestat, a neutrophil elastase inhibitor, on ipsilateral and contralateral testes after unilateral testicular ischaemia-reperfusion injury in rats
 BJU Int (Tsounapi P, Saito M, Dimitriadis F, Shimizu S, Kinoshita Y, Shomori K, Satoh I, Satoh K) 107/, 329-336 2011 (学術雑誌)

Protective effect of ischaemic post-conditioning on ipsilateral and contralateral testes after unilateral testicular ischaemia-reperfusion injury
 Int J Androl (Shimizu S, Saito M, Dimitriadis F, Kinoshita Y, Shomori K, Satoh I, Satoh K) 34/, 268-275 2011 (学術雑誌)

Nicorandil ameliorates ischaemia-reperfusion injury in the rat kidney
 Br J Pharmacol (Shimizu S, Saito M, Kinoshita Y, Ohmasa F, Dimitriadis F, Shomori K, Hayashi A, Satoh K) 163/, 272-282 2011 (学術雑誌)

Protective effect of taurine on diabetic rat endothelial dysfunction
 Biomed Res (Ikubo N, Saito M, Tsounapi P, Dimitriadis F, Ohmasa F, Inoue S, Shimizu S, Kinoshita Y, Satoh K) 32/, 187-193 2011 (学術雑誌)

Real-time monitoring of blood flow and intravesical pressure in the rat bladder
 LUTS (Saito M, Ohmasa F, Tsounapi P, Inoue S, Kinoshita Y, Dimitriadis F, Satoh K) 3/, 76-78 2011 (学術雑誌)

Edaravone ameliorates diabetes-induced dysfunction of NO-induced relaxation in corpus cavernosum smooth muscle in the rat
 J Sex Med (Ohmasa F, Saito M, Tsounapi P, Dimitriadis F, Inoue S, Shomori K, Shimizu S, Kinoshita Y, Satoh K) 8/, 1638-1649 2011 (学術雑誌)

Cytosolic phospholipase A2alpha contributes to blood pressure increases and endothelial dysfunction under chronic NO inhibition
 Arterioscler Thromb Vasc Biol (Tanaka K, Yamamoto Y, Ogino K, Tujimoto S, Saito M, Uozumi N, Shimizu T, Hisatome I) 31/, 1133-1138 2011 (学術雑誌)

Rhos and Rho kinases in the rat prostate: their possible functional roles and distributions
 Mol Cell Biochem (Saito M, Ohmasa F, Shomori K, Dimitriadis F, Ohiwa H, Shimizu S, Tsounapi P, Kinoshita Y, Satoh K) 358/, 207-213 2011 (学術雑誌)

The effect of ischemic preconditioning and postconditioning on testicular torsion-detorsion injury
 Global J Biochem (Shimizu S, Martin DT, Dimitriadis F, Satoh K, Saito M) 3/, 1 2012 (学術雑誌)

Intravesical treatment of oxybutynin for neurogenic bladder in children
 Pediatr Therapeut (Inoue I, Saito M, Honda M, Dimitriadis F, Takenaka A) 2/, 7 2012 (学術雑誌)

Effects of phosphodiesterase-5 inhibitor vardenafil on testicular androgen-binding protein secretion, the maintenance of foci of advanced spermatogenesis and the sperm fertilising capacity in azoospermic men
 Andrologia (Dimitriadis F, Tsampalas S, Tsounapi P, Giannakis D, Chaliasos N, Baltogiannis D, Miyagawa I, Saito M, Takenaka A, Sofikitis N) 44 Suppl 1/, 144-153 2012 (学術雑誌)

Nicorandil ameliorates hypertension-related bladder dysfunction in the rat
 Neurourol Urodyn (Saito M, Ohmasa F, Tsounapi P, Inoue S, Dimitriadis F, Kinoshita Y, Satoh K) 31/, 695-701 2012 (学術雑誌)

Effect of silodosin on detrusor overactivity in the male spontaneously hypertensive rat
 BJU Int (Inoue S, Saito M, Tsounapi P, Dimitriadis F, Ohmasa F, Kinoshita Y, Satoh K, Takenaka A) 110 (2 Pt B)/, E118-24 2012 (学術雑誌)

Fas expression in renal cell carcinoma accurately predicts patient survival after radical nephrectomy
 Urol Int (Sejima T, Morizane S, Hinata N, Yao A, Isoyama T, Saito M, Takenaka A) 88/, 263-270 2012 (学術雑誌)

Pharmacological preconditioning of ATP-sensitive potassium channel openers on acute urinary retention induced bladder dysfunction in the rat
 BJU Int (Ohmasa F, Saito M, Ohiwa H, Tsounapi P, Shomori K, Kitatani K, Dimitriadis F, Kinoshita Y, Satoh K) 110(6 Pt B)/, E245-252 2012 (学術雑誌)

Hydroxyfasudil ameliorates bladder dysfunction in the male spontaneously hypertensive rat
 Urology (Inoue S, Saito M, Takenaka A) 79/, e9-14 2012 (学術雑誌)

The role of K(ATP) channels on ischemia-reperfusion injury in the rat testis
 Life Sci (Tsounapi P, Saito M, Dimitriadis F, Kitatani K, Kinoshita Y, Shomori K, Takenaka A, Satoh K) 90/, 649-656 2012 (学術雑誌)

Hydroxyfasudil ameliorates penile dysfunction in the male spontaneously hypertensive rat
 Pharmacol Res (Saito M, Ohmasa F, Dimitriadis F, Tsounapi P, Sejima T, Shimizu S, Kinoshita Y, Satoh K) 66/, 325-331 2012 (学術雑誌)

Antioxidant treatment with edaravone or taurine ameliorates diabetes-induced testicular dysfunction in the rat
 Mol Cell Biochem (Tsounapi P, Saito M, Dimitriadis F, Koukos S, Shimizu S, Satoh K, Takenaka A, Sofikitis N) 369/, 195-204 2012 (学術雑誌)

Fasudil improves the endothelial dysfunction in the aorta of spontaneously hypertensive rats
 Eur J Pharmacol (Tsounapi P, Saito M, Kitatani K, Dimitriadis F, Ohmasa F, Shimizu S, Kinoshita Y, Takenaka A, Satoh K) 691/, 182-189 2012 (学術雑誌)

The effect of an angiotensin type I receptor blocker, olmesartan for bladder dysfunction in the spontaneously hypertensive rat
 Neurourol Urodyn (Saito M, Shimizu S, Oiwa H, Ohmasa F, Tsounapi P, Kinoshita Y, Satoh K) 31/, 802-803 2012 (学術雑誌)

The vasodilating drugs ameliorate detrusor overactivity via improving pelvic blood flow in the male spontaneously hypertensive rat
 Neurourol Urodyn (Inoue S, Saito M, Honda M, Hinata N, Tsounapi P, Kinoshita Y, Ohmasa F, Satoh K, Takenaka A) 31/, 1033 2012 (学術雑誌)

Editorial Comment to Higher glycosylated hemoglobin level increases the risk of overactive bladder syndrome in patients with type 2 diabetes mellitus
 Int J Urol (Saito M) 19/, 1001-1002 2012 (学術雑誌)

Characterization of silodosin and naftopidil in the treatment of bladder dysfunction in the spontaneously hypertensive rat
 Neurourol Urodyn (Saito M, Shimizu S, Ohmasa F, Oikawa R, Tsounapi P, Dimitriadis F, Kinoshita Y, Satoh K) 32/, 393-398 2013 (学術雑誌)

Editorial Comment to Interleukin-6 levels in female rats with protamine sulfate-induced chronic cystitis treated with hyaluronic acid
 Int J Urol (Saito M) /, In Press (学術雑誌)

Editorial Comment from Dr Saito and Dr Shimizu to Intravesical drug delivery for dysfunctional bladder
 Int J Urol (Saito M, Shimizu S) /, In Press (学術雑誌)

The significant immunological characteristics of peripheral blood neutrophil-to-lymphocyte ratio and Fas ligand expression incidence in nephrectomized tumor in late recurrence from renal cell carcinoma
 Urol Oncol (Sejima T, Iwamoto H, Morizane S, Hinata N, Yao A, Isoyama T, Saito M, Takenaka A) /, In Press (学術雑誌)

Fas expression in nephrectomized, non-cancerous specimens predicts post-nephrectomy chronic kidney disease progression in patients with renal and upper urinary tract malignancies
 Urol Oncol (Sejima T, Iwamoto H, Morizane S, Hinata N, Yao A, Isoyama T, Saito M, Amisaki T, Takenaka A) /, In Press (学術雑誌)

Supraspinal and spinal effects of L-trans-PDC, an inhibitor of glutamate transporter, on the micturition reflex in rats
 Neurourol Urodyn (Honda M, Yoshimura N, Hikita K, HinataN, Muraoka K, Saito M, Chancellar MB, Takeneka A) /, In Press (学術雑誌)

Olmesartan ameliorates urinary dysfunction in the spontaneously hy pertensive rat via recovering bladder blood flow and decreasing oxidative stress
 Neurourol Urodyn (Shimizu S, Saito M, Oiwa H, Ohmasa F, Tsounapi P, Oikawa R, Dimitriadis F, Martin DT, Satoh I, Kinoshita Y, Tomita S) /, In Press (学術雑誌)

The prognostic impact of pre-operative hematological disorders and a risk stratification model in bladder cancer patients treated with radical cystectomy
 Int J Urol (Sejima T, Morizane S, Yao A, Isoyama T, Saito M, Amisaki T, Koumi T, Takenaka A) /, In Press (学術雑誌)

■ 研究業績(著書)
Species-differences in diabetes-induced alterations of ureteral endothelin receptors(1996)
 出版社:Monduzzi Editore, Bologna

Androgen replacement–indications and principles. Clinical andrology: EAU/ESAU course guidelines(2010)
 出版社:Informa Healthcare Inc., New York

Focus in andrology and male infertility. Neutrophils: lifespan, functions and roles in disease(2010)
 出版社:Nova Science Publishers Inc., New York

Essentials of polymorphonuclear neutrophils and their roles in male infertility: “Friends or foes”(2010)
 出版社:Nova Science Publishers Inc., New York

New insights into the pathophysiology of the testis after ischemia-reperfusion injury. Testis: anatomy, physiology and pathology(2012)
 出版社:Nova Science Publishers Inc., New York

The Role of PDE5 Inhibitors in the Treatment of Testicular Dysfunction. Male Infertility(2012)
 出版社:InTech Publilshing Company, Rijeka

神経泌尿器科学研究法 (武田正之編) 第4章 Radioligand Binding Assay(2000)
 出版社:日本医学館,東京

Annual Review 腎臓 2008 第Z-6章 小児神経因性膀胱に対する塩酸オキシブチニン膀胱内注入療法(2008)
 出版社:中外医学社,東京

■ 研究業績(口頭・ポスター)
Nitric oxide and ischemia-reperfusion injury in the testis (Hellenic Society of Andrology 7th National Congress of Andrology, Athens 2006 口頭発表)

Bladder physiology and incontinence (Joint Seminar of Department of Urology and Obstetrics & Gynecology, University of Ioannina, Ioannina 2008 口頭発表)

Molecular mechanisms responsible for development of testicular damage in testicular torsion (3rd International Meeting of the Department of Urology of University of Ioannina, Porto Heli 2009 口頭発表)

Bladder blood flow and detrusor overactivity in the SHR (The 6th International symposium on receptor mechanism, signal transduction and drug effects, Kyoto 2011 口頭発表)

Effect of testicular ischemia-reperfusion on testicular function (Hellenic Society of Andrology 7th National Congress of Andrology, Athens 2006 口頭発表)

A probable role of seminal plasma and sperm polyamine content in the development of spermatozoal motility and their ability to undergo capacitation (18th Annual Meeting of American Society of Andrology, Tampa 1993 ポスター)

The effect of varicocele on the sperm acrosin system in rabbits (18th Annual Meeting of American Society of Andrology, Tampa 1993 ポスター)

Autoradiographic localization of β-adrenergic and muscarinic cholinergic receptors in diabetic rat prostate (American Urological Association 89th Annual Meeting, San Francisco 1994 ポスター)

Regional differences in the subtype specificity of muscarinic receptors in rabbit lower urinary tract (American Urological Association 89th Annual Meeting, San Francisco 1994 ポスター)

Light microscopic localization of muscarinic receptors in diabetic and diuretic rat bladder (12th International Society of Pharmacology Meeting, Montreal 1994 ポスター)

Diabetes increases the expression of endothelin receptors in rat ureter (American Urological Association 90th Annual Meeting, Las Vegas 1995 ポスター)

Evidence for the presences of regional differences in the properties of endothelin receptors in rabbit lower urinary tract (1st Congress on Urological Research organized by the European Society for Urological Oncology and Endocrinology (ESUOE) and the American Society for Basic Urological Research (SBUR), Rotterdam 1995 )

Characterization of endothelin receptors in vas deferens of diabetic rats (Experimental Biology 96, Washington DC 1996 ポスター)

Diabetes-induced alterations in the properties of α1 adrenergic receptors in the rat prostate (Experimental Biology 96, Washington DC 1996 ポスター)

Age related changes in endothelin receptors in rabbit bladder dome and base (American Urological Association 91st Annual Meeting, Orlando 1996 ポスター)

Subtype classification, localization and distribution of α1 adrenergic receptors in male rabbit urethra (American Urological Association 91st Annual Meeting, Orlando 1996 ポスター)

Diabetes-induced alterations in the properties of α1 adrenoceptors in the rat vas deferens (American Urological Association 91st Annual Meeting, Orlando 1996 ポスター)

Species-differences in diabetes induced alterations of ureteral endothelin receptors (International Society for the Upper Urinary Tract (ISDU) 11th Biannual Meeting, Patras 1996 ポスター)

Subtype specificity of muscarinic receptors in different regions of rabbit urinary tract (International Continence Society 26th Annual Meeting, Athens 1996 ポスター)

Endothelin receptors in diabetic rabbit prostate (Experimental Biology 97, New Orleans 1997 ポスター)

Endothelin receptors in diabetic rat bladder dome (International Continence Society 27th Annual Meeting, Yokohama 1997 ポスター)

Age related changes in endothelin receptors in rabbit lower urinary tract (International Continence Society 27th Annual Meeting, Yokohama 1997 ポスター)

Ontogeny of endothelin receptors in rabbit lower urinary tract (Experimental Biology 98, San Francisco 1998 ポスター)

Age related changes in endothelin receptors in rabbit renal pelvis (Experimental Biology 98, San Francisco 1998 ポスター)

Ontogeny of endothelin receptors in rabbit lower urinary tract: pharmacological and histological properties (American Urological Association 93rd Annual Meeting, San Diego 1998 ポスター)

Nitric oxide in ischemia-reperfusion rat bladder (International Continence Society 28th Annual Meeting, Jerusalem 1998 口頭発表)

Direct detection of nitric oxide in ischemia-reperfusion injury in the rat kidney (American Urological Association 94th Annual Meeting, Dallas 1999 ポスター)

Expression and localization of basic fibroblast growth factor in diabetic rat prostate (American Urological Association 94th Annual Meeting, Dallas 1999 ポスター)

Gene expression, localization, and pharmacological characterization of endothelin receptors in diabetic rat prostate (American Urological Association 94th Annual Meeting, Dallas 1999 ポスター)

The effect of nitric oxide in ischemia-reperfusion rat bladder (International Continence Society 29th Annual Meeting, Denver 1999 口頭発表)

Bladder dysfunction in acute urinary retention and subsequent catheterization (International Continence Society 30th Annual Meeting, Tampere 2000 口頭発表)

Efficacy of intravesical oxybutynin chloride with hydroxypropyl cellurose (HPC) (25th SIU World Congress, Singapore 2000 ポスター)

Influence of micturition posture on uroflowmetry results: standing vs. sitting position (25th SIU World Congress, Singapore 2000 ポスター)

NOS inhibitors prevent apoptosis induced by ischemia-reperfusion in the rat bladder (International Continence Society 31st Annual Meeting, Seoul 2001 ポスター)

Effects of L-arginine on bladder function in bladder-outlet-obstructed rats (International Continence Society 32nd Annual Meeting, Heidelberg 2002 ポスター)

Preventive effect of long-chain fatty alcohol on ischemia-reperfusion injury in the rat bladder (International Continence Society 32nd Annual Meeting, Heidelberg 2002 ポスター)

Expression of HSP70 mRNAs during ischemia-reperfusion in the rat bladder (International Continence Society 33rd Annual Meeting, Florence 2003 ポスター)

Preventive effect of cyclohexenonic long-chain fatty alcohol on rat overactive bladder induced by bladder neck obstruction (Joint meeting of the International Continence Society and the International UroGynecological Association 34th Annual Meeting, Paris 2004 ポスター)

Non-steroidal anti-inflammatory drugs inhibit frequency and volume of micturition temporary in male rats: difference between conscious and anesthetized rats (Joint meeting of the International Continence Society and the International UroGynecological Association 34th Annual Meeting, Paris 2004 ポスター)

Effectiveness of an anti-inflammatory drug, loxoprofen, in patients with nocturia (Joint meeting of the International Continence Society and the International UroGynecological Association 34th Annual Meeting, Paris 2004 ポスター)

Non-steroidal anti-inflammatory drugs inhibit frequency and volume of micturition temporary in male rats: difference between conscious and anesthetized rats (Neuroscience Meeting 2004, San Diego 2004 ポスター)

Amelioration of STZ-induced diabetic cystopathy caused by N-hexacosanol (International Continence Society 35th Annual Meeting, Montreal 2005 ポスター)

Amelioration of STZ-induced diabetic rat nephropathy by N-hexacosanol (ASN (The American Society of Nephrology) Renal Week 2005, Philadelphia 2005 ポスター)

Real-time monitoring of nitric oxide and blood flow during ischemia-reperfusion in the rat testis (American Urological Association 101st Annual Meeting, Atlanta 2006 ポスター)

Beneficial effects of N-hexacosanol on STZ-induced diabetic rat aorta smooth muscle (15th International Society of Pharmacology Meeting, Beijing 2006 ポスター)

Cyclohexenonic long-chain fatty alcohol reverses diabetic induced dysfunction of ileum in the rat (15th International Society of Pharmacology Meeting, Beijing 2006 ポスター)

Ability of cyclohexenonic long-chain fatty alcohol to reverse diabetes-induced cystopathy in the rat (15th International Society of Pharmacology Meeting, Beijing 2006 ポスター)

Beneficial effects of N-hexacosanol on STZ-induced diabetic rat trachea (15th International Society of Pharmacology Meeting, Beijing 2006 ポスター)

Chromosomal abnormalities, FasL expression, and telomerase activity in testicular specimens collected from men with testicular calcifications (Hellenic Society of Andrology 7th National Congress of Andrology, Athens 2006 口頭発表)

Beneficial effect of preconditioning on ischemia-reperfusion injury in the rat bladder in vivo (International Continence Society 37th Annual Meeting, Rotterdam 2007 ポスター)

Treatment with modified intravesical oxybutynin chloride for neurogenic bladder in children (International Continence Society 37th Annual Meeting, Rotterdam 2007 ポスター)

Pharmacological properties, functional alterations, and gene expression of muscarinic receptors in young and old type 2 GK diabetic rat bladders (International Continence Society 38th Annual Meeting, Cairo 2008 ポスター)

Effects of phosphodiesterase-5 inhibitors on Leydig cell secretory function (24th Annual EAU Congress, Stockholm 2009 ポスター)

Effects of cyclohexenonic long-chain fatty alcohol (CHLFA) in type 2 diabetic rat nephropathy (World Congress of Nephrology 2009, Milan 2009 ポスター)

Functional and histological changes after acute urinary retention in the rat (International Continence Society 39th Annual Meeting, San Francisco 2009 ポスター)

Effect of Rho-kinase inhibitor, fasudil, on bladder overactivity in an experimental cystitis rat model (International Continence Society 39th Annual Meeting, San Francisco 2009 ポスター)

Muscarinic receptor systems in young and old type II Goto-Kakizaki diabetic rat prostate (International Continence Society 40th Annual Meeting, Toronto 2010 ポスター)

Protective effect of sivelestat, a neutrophil elastase inhibitor, on ipsilateral and contralateral testes after unilateral testicular ischaemia-reperfusion injury in rats (20th Congress of the Hellenic Urological Association, Lemesos 2010 ポスター)

Protective effect of free radical scavengers, taurine and edaravone on diabetes-induced penile dysfunction (American Urological Association 106th Annual Meeting, Washington DC 2011 ポスター)

Nicorandil ameliorates detrusor overactivity in the SHR (International Continence Society 41st Annual Meeting, Glasgow 2011 ポスター)

Effect of silodosin on detrusor overactivity in the male spontaneously hypertensive rat (International Continence Society 41st Annual Meeting, Glasgow 2011 ポスター)

Nicorandil ameliorates hypertension-related detrusor overactivity in the SHR (6th Pan-Pacific Continence Society (PPCS) Meeting, Taipei 2011 ポスター)

Effect of silodosin on detrusor overactivity in the male spontaneously hypertensive rat (6th Pan-Pacific Continence Society (PPCS) Meeting, Taipei 2011 ポスター)

Effect of intravesical botulinum toxin A delivery (using DMSO) in rat overactive bladder model (American Urological Association 107th Annual Meeting, Atlanta 2012 ポスター)

The effect of an angiotensin type I receptor blocker, olmesartan for bladder dysfunction in the spontaneously hypertensive rat (International Continence Society 42nd Annual Meeting, Beijin 2012 ポスター)

The vasodilating drugs ameliorate detrusor overactivity via improving pelvic blood flow in the male spontaneously hypertensive rat (International Continence Society 42nd Annual Meeting, Beijin 2012 ポスター)

Inhibition of the anandamine transpoter inhibits the micturition reflex of anesthetized rats (American Urological Association 108th Annual Meeting, San Diego 2013 ポスター)

The effect of Hydroxyfasudil on penile dysfunction in the male spontaneously hypertensive rat (American Urological Association 108th Annual Meeting, San Diego 2013 ポスター)

Angiotensin II receptor blocker, olmesartan preserves bladder blood flow and oxidative stress, and improves bladder dysfunction in the spontaneously hypertensive rat (American Urological Association 108th Annual Meeting, San Diego 2013 ポスター)

■ 研究業績(特許)
糖尿病性血管障害および呼吸障害予防および/または治療剤
 国際公開番号WO2006/126295 日本での出願番号 特願2005-153990

腎機能障害改善剤
 国際公開番号WO2006/057346 日本での出願番号 特願2006-547864

■ 研究業績(その他の活動)


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