■ 氏名
山口 正洋 (ヤマグチ マサヒロ)
YAMAGUCHI Masahiro

■ 所属部局/職名
Research and Education Faculty, Medical Sciences Cluster, Basic Medicine Unit/Professor
教育研究部 医療学系 基礎医学部門/教授

■ 学部・学科・コース等
Medical School, Medical Course, Department of Physiology
医学部 医学科 生理学

■ 連絡先
住 所
電 話
F A X
E-Mail
U R L

■ 出身大学院・研究科等

■ 出身学校・専攻等

■ 取得学位
医学博士 () 京都大学

■ 研究職歴

■ 委員歴・役員歴

■ 受賞学術賞

■ 所属学会

■ 専門分野

■ 主な研究テーマ・活動

■ 研究についてのPR

■ 社会人・生徒を対象として可能な講演・授業(例えば講演題目)

■ 研究業績(論文・解説)
Japanese Soy Sauce Improves Upper Limb Performance.
 Occupational Therapy International (Yano Y, Murata Y, Taniguchi M, Okutani F, Yamaguchi M, Kaba H.) 2019/, ID 2748721 2019 () 10.1155/2019/2748721

GABAergic neurons in the olfactory cortex projecting to the lateral hypothalamus in mice.
 Scientific Reports (Murata K, Kinoshita T, Fukazawa Y, Kobayashi K, Kobayashi K, Miyamichi K, Okuno H, Bito H, Sakurai Y, Yamaguchi M, Mori K, Manabe H.) 9/, article 7132 2019 () 10.1038/s41598-019-43580-1

Opposing roles of dopamine receptor D1- and D2-expressing neurons in the anteromedial olfactory tubercle in acquisition of place preference in mice.
 Frontiers in Behavioral Neuroscience (Murata K, Kinoshita T, Fukazawa Y, Kobayashi K, Yamanaka A, Hikida T, Manabe H, Yamaguchi M.) 13/, article 50 2019 () 10.3389/fnbeh.2019.00050.

Representations of microgeometric tactile information during object recognition.
 Cognitive processing (Yasaka K, Mori T, Yamaguchi M, Kaba H) /, 201811 () 10.1007/s10339-018-0892-3

Functional development of olfactory tubercle domains during weaning period in mice.
 Scientific reports (Murofushi W, Mori K, Murata K, Yamaguchi M) 8/1, 13204 201809 () 10.1038/s41598-018-31604-1

Cigarette smoke directly impairs skeletal muscle function through capillary regression and altered myofibre calcium kinetics in mice.
 The Journal of physiology (Nogueira L, Trisko BM, Lima-Rosa FL, Jackson J, Lund-Palau H, Yamaguchi M, Breen EC) 596/14, 2901-2916 201807 () 10.1113/JP275888

α2-Adrenergic receptor activation promotes long-term potentiation at excitatory synapses in the mouse accessory olfactory bulb.
 Learning & memory (Cold Spring Harbor, N.Y.) (Huang GZ, Taniguchi M, Zhou YB, Zhang JJ, Okutani F, Murata Y, Yamaguchi M, Kaba H) 25/4, 147-157 201804 () 10.1101/lm.046391.117

Area-Specific Regulation of Quiescent Neural Stem Cells by Notch3 in the Adult Mouse Subependymal Zone.
 The Journal of neuroscience : the official journal of the Society for Neuroscience (Kawai H, Kawaguchi D, Kuebrich BD, Kitamoto T, Yamaguchi M, Gotoh Y, Furutachi S) 37/49, 11867-11880 201712 () 10.1523/JNEUROSCI.0001-17.2017

CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility.
 Neurobiology of disease (Okuda K, Kobayashi S, Fukaya M, Watanabe A, Murakami T, Hagiwara M, Sato T, Ueno H, Ogonuki N, Komano-Inoue S, Manabe H, Yamaguchi M, Ogura A, Asahara H, Sakagami H, Mizuguchi M, Manabe T, Tanaka T) 106/, 158-170 201710 () 10.1016/j.nbd.2017.07.002

Skeletal myofiber vascular endothelial growth factor is required for the exercise training-induced increase in dentate gyrus neuronal precursor cells.
 The Journal of physiology (Rich B, Scadeng M, Yamaguchi M, Wagner PD, Breen EC) 595/17, 5931-5943 201709 () 10.1113/JP273994

Differences in characteristics of glucose intolerance between patients with NAFLD and chronic hepatitis C as determined by CGMS.
 Scientific reports (Ochi T, Kawaguchi T, Nakahara T, Ono M, Noguchi S, Koshiyama Y, Munekage K, Murakami E, Hiramatsu A, Ogasawara M, Hirose A, Mizuta H, Masuda K, Okamoto N, Suganuma N, Chayama K, Yamaguchi M, Torimura T, Saibara T) 7/1, 10146 201708 () 10.1038/s41598-017-09256-4

The role of sleep in the plasticity of the olfactory system.
 Neuroscience research (Yamaguchi M) 118/, 21-29 201705 () 10.1016/j.neures.2017.03.014

Mesenchymal Stem Cell Therapy Protects Lungs from Radiation-Induced Endothelial Cell Loss by Restoring Superoxide Dismutase 1 Expression.
 Antioxidants & redox signaling (Klein D, Steens J, Wiesemann A, Schulz F, Kaschani F, R?ck K, Yamaguchi M, Wirsd?rfer F, Kaiser M, Fischer JW, Stuschke M, Jendrossek V) 26/11, 563-582 201704 () 10.1089/ars.2016.6748

Functional Sub-Circuits of the Olfactory System Viewed from the Olfactory Bulb and the Olfactory Tubercle.
 Frontiers in neuroanatomy (Yamaguchi M) 11/, 33 2017 () 10.3389/fnana.2017.00033

Activation of arginine vasopressin receptor 1a facilitates the induction of long-term potentiation in the accessory olfactory bulb of male mice.
 Neuroscience letters (Namba T, Taniguchi M, Murata Y, Tong J, Wang Y, Okutani F, Yamaguchi M, Kaba H) 634/, 107-113 201611 () 10.1016/j.neulet.2016.09.056

The Dorsoventral Boundary of the Germinal Zone is a Specialized Niche for the Generation of Cortical Oligodendrocytes during a Restricted Temporal Window.
 Cerebral cortex (New York, N.Y. : 1991) (Naruse M, Ishino Y, Kumar A, Ono K, Takebayashi H, Yamaguchi M, Ishizaki Y, Ikenaka K, Hitoshi S) 26/6, 2800-2810 201606 () 10.1093/cercor/bhv141

Neural stem cells and neuro/gliogenesis in the central nervous system: understanding the structural and functional plasticity of the developing, mature, and diseased brain.
 The journal of physiological sciences : JPS (Yamaguchi M, Seki T, Imayoshi I, Tamamaki N, Hayashi Y, Tatebayashi Y, Hitoshi S) 66/3, 197-206 201605 () 10.1007/s12576-015-0421-4

Mapping of Learned Odor-Induced Motivated Behaviors in the Mouse Olfactory Tubercle.
 The Journal of neuroscience : the official journal of the Society for Neuroscience (Murata K, Kanno M, Ieki N, Mori K, Yamaguchi M) 35/29, 10581-10599 201507 () 10.1523/JNEUROSCI.0073-15.2015

Rapid induction of granule cell elimination in the olfactory bulb by noxious stimulation in mice.
 Neuroscience letters (Komano-Inoue S, Murata K, Mori K, Yamaguchi M) 598/, 43993 201506 () 10.1016/j.neulet.2015.05.002

Nasal Administration of Cholera Toxin as a Mucosal Adjuvant Damages the Olfactory System in Mice.
 PloS one (Fukuyama Y, Okada K, Yamaguchi M, Kiyono H, Mori K, Yuki Y) 10/9, e0139368 2015 () 10.1371/journal.pone.0139368

Top-down inputs from the olfactory cortex in the postprandial period promote elimination of granule cells in the olfactory bulb.
 The European journal of neuroscience (Komano-Inoue S, Manabe H, Ota M, Kusumoto-Yoshida I, Yokoyama TK, Mori K, Yamaguchi M) 40/5, 2724-2733 201409 () 10.1111/ejn.12679

Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning.
 The Journal of neuroscience : the official journal of the Society for Neuroscience (Sakamoto M, Ieki N, Miyoshi G, Mochimaru D, Miyachi H, Imura T, Yamaguchi M, Fishell G, Mori K, Kageyama R, Imayoshi I) 34/17, 5788-5799 201404 () 10.1523/JNEUROSCI.0674-14.2014

Critical periods in adult neurogenesis and possible clinical utilization of new neurons.
 Frontiers in neuroscience (Yamaguchi M, Mori K) 8/, 177 2014 () 10.3389/fnins.2014.00177

Nestin(+) tissue-resident multipotent stem cells contribute to tumor progression by differentiating into pericytes and smooth muscle cells resulting in blood vessel remodeling.
 Frontiers in oncology (Klein D, Meissner N, Kleff V, Jastrow H, Yamaguchi M, Erg?n S, Jendrossek V) 4/, 169 2014 () 10.3389/fonc.2014.00169

Reorganization of neuronal circuits of the central olfactory system during postprandial sleep.
 Frontiers in neural circuits (Yamaguchi M, Manabe H, Murata K, Mori K) 7/, 132 2013 () 10.3389/fncir.2013.00132

Visualization of odor-induced neuronal activity by immediate early gene expression.
 BMC neuroscience (Bepari AK, Watanabe K, Yamaguchi M, Tamamaki N, Takebayashi H) 13/, 140 201211 () 10.1186/1471-2202-13-140

Elimination of adult-born neurons in the olfactory bulb is promoted during the postprandial period.
 Neuron (Yokoyama TK, Mochimaru D, Murata K, Manabe H, Kobayakawa K, Kobayakawa R, Sakano H, Mori K, Yamaguchi M) 71/5, 883 201109 () 10.1016/j.neuron.2011.05.046

Compensation of depleted neuronal subsets by new neurons in a local area of the adult olfactory bulb.
 The Journal of neuroscience : the official journal of the Society for Neuroscience (Murata K, Imai M, Nakanishi S, Watanabe D, Pastan I, Kobayashi K, Nihira T, Mochizuki H, Yamada S, Mori K, Yamaguchi M) 31/29, 10540-10557 201107 () 10.1523/JNEUROSCI.1285-11.2011

Continuous neurogenesis in the adult forebrain is required for innate olfactory responses.
 Proceedings of the National Academy of Sciences of the United States of America (Sakamoto M, Imayoshi I, Ohtsuka T, Yamaguchi M, Mori K, Kageyama R) 108/20, 8479-8484 201105 () 10.1073/pnas.1018782108

Valosin-containing protein (VCP) in novel feedback machinery between abnormal protein accumulation and transcriptional suppression.
 The Journal of biological chemistry (Koike M, Fukushi J, Ichinohe Y, Higashimae N, Fujishiro M, Sasaki C, Yamaguchi M, Uchihara T, Yagishita S, Ohizumi H, Hori S, Kakizuka A) 285/28, 21736-21749 201007 () 10.1074/jbc.M109.099283

Essential roles of Notch signaling in maintenance of neural stem cells in developing and adult brains.
 The Journal of neuroscience : the official journal of the Society for Neuroscience (Imayoshi I, Sakamoto M, Yamaguchi M, Mori K, Kageyama R) 30/9, 3489-3498 201003 () 10.1523/JNEUROSCI.4987-09.2010

Perisomatic-targeting granule cells in the mouse olfactory bulb.
 The Journal of comparative neurology (Naritsuka H, Sakai K, Hashikawa T, Mori K, Yamaguchi M) 515/, 409-426 20090801 () 10.1002/cne.22063

Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain.
 Nature neuroscience (Imayoshi I, Sakamoto M, Ohtsuka T, Takao K, Miyakawa T, Yamaguchi M, Mori K, Ikeda T, Itohara S, Kageyama R) 11/10, 1153-1161 200810 () 10.1038/nn.2185

Enhanced cell-to-cell contacts between activated microglia and pyramidal cell dendrites following kainic acid-induced neurotoxicity in the hippocampus.
 Journal of neuroimmunology (Hasegawa S, Yamaguchi M, Nagao H, Mishina M, Mori K) 186/, 75-85 200705 () 10.1016/j.jneuroim.2007.03.005

Maps of odorant molecular features in the Mammalian olfactory bulb.
 Physiological reviews (Mori K, Takahashi YK, Igarashi KM, Yamaguchi M) 86/2, 409-433 200604 () 10.1152/physrev.00021.2005

Critical period for sensory experience-dependent survival of newly generated granule cells in the adult mouse olfactory bulb.
 Proceedings of the National Academy of Sciences of the United States of America (Yamaguchi M, Mori K) 102/27, 9697-9702 20050705 () 10.1073/pnas.0406082102

Analysis of neurogenesis using transgenic mice expressing GFP with nestin gene regulatory regions.
 Chemical senses (Yamaguchi M) 30 Suppl 1/, i117-8 200501 () 10.1093/chemse/bjh142

Activated natural killer cells adhere to cultured hippocampal neurons and affect the dendritic morphology.
 Journal of neuroimmunology (Hasegawa S, Yamaguchi M, Nagao H, Yoshihara Y, Mori K) 151/, 126-136 200406 () 10.1016/j.jneuroim.2004.03.002

Two distinct subpopulations of nestin-positive cells in adult mouse dentate gyrus.
 The Journal of neuroscience : the official journal of the Society for Neuroscience (Fukuda S, Kato F, Tozuka Y, Yamaguchi M, Miyamoto Y, Hisatsune T) 23/, 9357-9366 20031001 ()

Decrease in expression of alpha 5 beta 1 integrin during neuronal differentiation of cortical progenitor cells.
 Experimental cell research (Yoshida N, Hishiyama S, Yamaguchi M, Hashiguchi M, Miyamoto Y, Kaminogawa S, Hisatsune T) 287/2, 262-271 20030701 () 10.1016/S0014-4827(03)00158-7

Distorted odor maps in the olfactory bulb of semaphorin 3A-deficient mice.
 The Journal of neuroscience : the official journal of the Society for Neuroscience (Taniguchi M, Nagao H, Takahashi YK, Yamaguchi M, Mitsui S, Yagi T, Mori K, Shimizu T) 23/, 1390-1397 20030201 ()

Grouping and representation of odorant receptors in domains of the olfactory bulb sensory map.
 Microscopy research and technique (Nagao H, Yamaguchi M, Takahash Y, Mori K) 58/, 168-175 20020801 () 10.1002/jemt.10146

匂い行動と腹側線条体:嗅結節の構造と機能
 Clinical Neuroscience (山口 正洋) 36/12, 1415-1417 201812 ()

食べる意欲と食嗜好を支える嗅覚神経回路 (食の嗜好性と依存的食行動をめぐる脳科学と食品機能性科学の最前線 : 肥満症診療のNew Frontier)
 肥満研究 = Journal of Japan Society for the Study of Obesity : 日本肥満学会誌 (山口 正洋) 24/2, 79-83 2018 ()

【食欲と食嗜好のサイエンス 体外からの味・匂いと体内の栄養情報に揺り動かされる決断のメカニズム】 食行動を支える嗅覚 匂いによる食欲の制御機構
 実験医学 (山口 正洋) 35/6, 911-916 201704 ()

嗅覚神経回路の可塑性と個体の情動応答
 日本味と匂学会誌 = The Japanese journal of taste and smell research (山口 正洋) 24/1, 43900 201704 () 10.18965/tasteandsmell.24.1_3

匂い情報の皮質処理 : 嗅皮質の構造と機能について (特集 大脳皮質 : 成り立ちから機能へ)
 生体の科学 (山口 正洋) 68/1, 64-68 201701 () 10.11477/mf.2425200577

【嗅覚-New horizon】 受容と伝達のメカニズム 嗅上皮と嗅球におけるニューロン新生
 Clinical Neuroscience (山口 正洋) 34/12, 1316-1319 201612 ()

情動を動かす嗅覚 匂いによる情動、感情、痛み管理の可能性
 日本臨床麻酔学会誌 (山口 正洋) 36/6, S145-S145 201610 ()

匂いの学習記憶 : 覚醒睡眠サイクルと情動の役割 (特集 記憶ふたたび)
 生体の科学 (山口 正洋) 67/1, 61-65 201601 () 10.11477/mf.2425200400

大人でも新しく生まれる嗅覚系神経細胞 (AYUMI 嗅覚の脳神経科学の最前線)
 医学のあゆみ (山口 正洋) 253/6, 481-486 20150509 ()

嗅覚と食べ物のおいしさ・好き嫌いについて (特集 おいしさを科学する)
 Aroma research = アロマリサーチ : journal of aroma science technology and safety (山口 正洋) 14/3, 207-211 2013 ()

匂いの神経回路は食事のあとに再構成される
 Aroma Research (山口 正洋) 13/1, 38-39 2012 ()

【嗅覚障害と神経変性疾患】 嗅覚障害と神経新生
 脳21 (山口 正洋) 14/4, 345-348 201110 ()

味覚・嗅覚受容体研究の最前線‐4 匂い経験で新しくなる嗅覚系の神経細胞
 化学と生物 (山口正洋) 48/5, 346-351 20100501 () 10.1271/kagakutoseibutsu.48.346

知っておきたい健康情報 においを感じる仕組みを知ろう
 こころのオアシス (山口 正洋) 5/8, 38-40 200708 ()

脊髄損傷を嗅覚系の細胞で治療する Olfactory ensheathing cellは救世主となり得るか
 Aroma Research (山口 正洋) 8/2, 140-140 200705 ()

Current Topics 嗅覚神経回路は匂い刺激で変化する--嗅球新生神経細胞の生死決定機構
 Aroma research (山口 正洋) 6/4, 352-355 2005 ()

S-1-7 Neurogenesis in the adult olfactory bulb(<特集>ISOT/JASTS 2004)
 日本味と匂学会誌 (山口正洋) 11/3, 287-288 200412 ()

【感覚受容の分子機構を探る 嗅・味・痛覚の受容体研究と医学応用への可能性】 嗅覚系の神経回路と情報処理機構
 実験医学 (山口 正洋, 森 憲作) 18/17, 2302-2307 200011 ()

【骨形成の新機能を探る-Reverse Geneticsで解明する骨代謝】 ドミナントネガティブ型レチノイン酸受容体によって誘導された骨格異常
 実験医学 (垣塚 彰, 山口 正洋) 16/2, 126-130 199802 ()

■ 研究業績(著書)
The olfactory system: from odor molecules to motivational behaviors.(2014)
 出版社:Springer

Neurogenesis in the Adult Brain.(2011)
 出版社:Springer

■ 研究業績(口頭・ポスター)
Role of olfactory tubercle in the weaning process of neonatal mice (The 18th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception 2019 ポスター)

食行動における嗅覚の働き -脳と体を結びつけるメカニズム- (口腔ブレインサイエンス 2019 )

嗅球新生ニューロンへの入力と選別機構 (第15回成体脳ニューロン新生懇談会 2019 )

匂い行動の発達と学習に関わる嗅皮質領域 (日本味と匂学会第52回大会 2018 )

匂いに基づく食の嗜好性とモチベーションの神経機構 (口腔ブレインサイエンス 2018 )

食を支える匂いの感覚―匂いによる食欲促進について― (明石地区病院栄養士会 2018 )

匂いが食のモチベーションを誘導する神経機構 (第72回日本栄養・食糧学会大会 2018 )

Neural circuit for acquiring distinct odor-guided motivated behaviors in mice (第95回日本生理学会 2018 )

Neural circuit mechanism of odor-induced motivation of feeding (第40回日本分子生物学会年会・第90回日本生化学会大会合同大会 2017 )

食嗜好の学習に関わる嗅覚神経回路 (第2回 食欲・食嗜好の分子・神経基盤研究会 2017 )

情動を動かす嗅覚:匂いによる情動、感情、痛み管理の可能性 (日本臨床麻酔学会第36回大会 2016 )

■ 研究業績(特許)

■ 研究業績(その他の活動)


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