■ 氏名
仲 哲治 (ナカ テツジ)
NAKA Tetsuji

■ 所属部局/職名
教育研究部(学系・部門)以外の所属/特任教授

■ 学部・学科・コース等
Medical School, Medical Course, Department of Clinical immunology
医学部 医学科 臨床免疫学

■ 連絡先
住 所
電 話
F A X
E-Mail
U R L

■ 出身大学院・研究科等

■ 出身学校・専攻等

■ 取得学位
博士(医学) ()

■ 研究職歴

■ 委員歴・役員歴

■ 受賞学術賞

■ 所属学会

■ 専門分野

■ 主な研究テーマ・活動

■ 研究についてのPR

■ 社会人・生徒を対象として可能な講演・授業(例えば講演題目)

■ 研究業績(論文・解説)
NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IκB-ζ degradation.
 The Journal of experimental medicine (Kimura A, Kitajima M, Nishida K, Serada S, Fujimoto M, Naka T, Fujii-Kuriyama Y, Sakamato S, Ito T, Handa H, Tanaka T, Yoshimura A, Suzuki H) 215/8, 2197-2209 201808 () 10.1084/jem.20172024

Intratumoral delivery of an adenoviral vector carrying the SOCS-1 gene enhances T cell-mediated anti-tumor immunity by suppressing PD-L1.
 Molecular cancer therapeutics (Nakagawa S, Serada S, Kakubari R, Hiramatsu K, Sugase T, Matsuzaki S, Matsuzaki S, Ueda Y, Yoshino K, Ohkawara T, Fujimoto M, Kishimoto T, Kimura T, Naka T) /, 201806 () 10.1158/1535-7163.MCT-17-0822

Leucine rich α-2 glycoprotein is a potential urinary biomarker for renal tubular injury.
 Biochemical and biophysical research communications (Lee H, Fujimoto M, Ohkawara T, Honda H, Serada S, Terada Y, Naka T) 498/4, 1045-1051 201804 () 10.1016/j.bbrc.2018.03.111

SOCS1 gene therapy has antitumor effects in imatinib-resistant gastrointestinal stromal tumor cells through FAK/PI3?K signaling.
 Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (Sugase T, Takahashi T, Serada S, Fujimoto M, Ohkawara T, Hiramatsu K, Nishida T, Hirota S, Saito Y, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Hanasaki K, Kishimoto T, Mori M, Doki Y, Naka T) /, 201804 () 10.1007/s10120-018-0822-1

Anti-glypican-1 antibody-drug conjugate exhibits potent preclinical antitumor activity against glypican-1 positive uterine cervical cancer.
 International journal of cancer (Matsuzaki S, Serada S, Hiramatsu K, Nojima S, Matsuzaki S, Ueda Y, Ohkawara T, Mabuchi S, Fujimoto M, Morii E, Yoshino K, Kimura T, Naka T) 142/5, 1056-1066 201803 () 10.1002/ijc.31124

LSR Antibody Therapy Inhibits Ovarian Epithelial Tumor Growth by Inhibiting Lipid Uptake.
 Cancer research (Hiramatsu K, Serada S, Enomoto T, Takahashi Y, Nakagawa S, Nojima S, Morimoto A, Matsuzaki S, Yokoyama T, Takahashi T, Fujimoto M, Takemori H, Ueda Y, Yoshino K, Morii E, Kimura T, Naka T) 78/2, 516-527 201801 () 10.1158/0008-5472.CAN-17-0910

SOCS1 Gene Therapy Improves Radiosensitivity and Enhances Irradiation-Induced DNA Damage in Esophageal Squamous Cell Carcinoma.
 Cancer research (Sugase T, Takahashi T, Serada S, Fujimoto M, Hiramatsu K, Ohkawara T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Kishimoto T, Mori M, Doki Y, Naka T) 77/24, 6975-6986 201712 () 10.1158/0008-5472.CAN-17-1525

Leucine-rich α-2 glycoprotein promotes lung fibrosis by modulating TGF-β signaling in fibroblasts.
 Physiological reports (Honda H, Fujimoto M, Serada S, Urushima H, Mishima T, Lee H, Ohkawara T, Kohno N, Hattori N, Yokoyama A, Naka T) 5/24, 201712 () 10.14814/phy2.13556

Suppressor of cytokine signaling-1 gene therapy induces potent antitumor effect in patient-derived esophageal squamous cell carcinoma xenograft mice.
 International journal of cancer (Sugase T, Takahashi T, Serada S, Nakatsuka R, Fujimoto M, Ohkawara T, Hara H, Nishigaki T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Takiguchi S, Kishimoto T, Mori M, Doki Y, Naka T) 140/11, 2608-2621 201706 () 10.1002/ijc.30666

Leucine-rich alpha 2 glycoprotein promotes Th17 differentiation and collagen-induced arthritis in mice through enhancement of TGF-β-Smad2 signaling in na?ve helper T cells.
 Arthritis research & therapy (Urushima H, Fujimoto M, Mishima T, Ohkawara T, Honda H, Lee H, Kawahata H, Serada S, Naka T) 19/1, 137 201706 () 10.1186/s13075-017-1349-2

Leucine-rich α-2 glycoprotein is an innovative biomarker for psoriasis.
 Journal of dermatological science (Nakajima H, Serada S, Fujimoto M, Naka T, Sano S) 86/2, 170-174 201705 () 10.1016/j.jdermsci.2017.01.008

A novel pathogenesis of inflammatory bowel disease from the perspective of glyco-immunology.
 Journal of biochemistry (Shinzaki S, Iijima H, Fujii H, Kamada Y, Naka T, Takehara T, Miyoshi E) 161/5, 409-415 201705 () 10.1093/jb/mvx010

Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors.
 Genes, chromosomes & cancer (Takahashi T, Elzawahry A, Mimaki S, Furukawa E, Nakatsuka R, Nakamura H, Nishigaki T, Serada S, Naka T, Hirota S, Shibata T, Tsuchihara K, Nishida T, Kato M) 56/4, 303-313 201704 () 10.1002/gcc.22438

Glypican-1 targeted antibody-based therapy induces preclinical antitumor activity against esophageal squamous cell carcinoma.
 Oncotarget (Harada E, Serada S, Fujimoto M, Takahashi Y, Takahashi T, Hara H, Nakatsuka R, Sugase T, Nishigaki T, Saito Y, Hiramatsu K, Nojima S, Mitsuo R, Ohkawara T, Morii E, Mori M, Doki Y, Kaneda Y, Naka T) 8/15, 24741-24752 201704 () 10.18632/oncotarget.15799

Splicing factor proline/glutamine-rich is a novel autoantigen of dermatomyositis and associated with anti-melanoma differentiation-associated gene 5 antibody.
 Journal of autoimmunity (Hosono Y, Nakashima R, Serada S, Murakami K, Imura Y, Yoshifuji H, Ohmura K, Naka T, Mimori T) 77/, 116-122 201702 () 10.1016/j.jaut.2016.11.006

Leucine-rich Alpha-2 Glycoprotein is a Serum Biomarker of Mucosal Healing in Ulcerative Colitis.
 Journal of Crohn's & colitis (Shinzaki S, Matsuoka K, Iijima H, Mizuno S, Serada S, Fujimoto M, Arai N, Koyama N, Morii E, Watanabe M, Hibi T, Kanai T, Takehara T, Naka T) 11/1, 84-91 201701 () 10.1093/ecco-jcc/jjw132

A novel approach of optical biopsy using probe-based confocal laser endomicroscopy for peritoneal metastasis.
 Surgical endoscopy (Hara H, Takahashi T, Nakatsuka R, Higashi S, Naka T, Sumiyama K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Takiguchi S, Mori M, Doki Y, Nakajima K) 30/8, 3437-3446 201608 () 10.1007/s00464-015-4626-7

Overexpression of glypican-1 implicates poor prognosis and their chemoresistance in oesophageal squamous cell carcinoma.
 British journal of cancer (Hara H, Takahashi T, Serada S, Fujimoto M, Ohkawara T, Nakatsuka R, Harada E, Nishigaki T, Takahashi Y, Nojima S, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Morii E, Mori M, Doki Y, Naka T) 115/1, 66-75 201606 () 10.1038/bjc.2016.183

Increased serum CXCR2 ligand levels in livedo vasculopathy with winter ulcerations: Possible contribution of neutrophil recruitment to lesional skin.
 Journal of dermatological science (Yang L, Murota H, Shindo S, Yang F, Serada S, Fujimoto M, Naka T, Katayama I) 82/1, 57-59 201604 () 10.1016/j.jdermsci.2016.01.004

Large-scale proteome analysis of abscisic acid and ABSCISIC ACID INSENSITIVE3-dependent proteins related to desiccation tolerance in Physcomitrella patens.
 Biochemical and biophysical research communications (Yotsui I, Serada S, Naka T, Saruhashi M, Taji T, Hayashi T, Quatrano RS, Sakata Y) 471/4, 589-595 201603 () 10.1016/j.bbrc.2016.02.024

Similar protein expression profiles of ovarian and endometrial high-grade serous carcinomas.
 British journal of cancer (Hiramatsu K, Yoshino K, Serada S, Yoshihara K, Hori Y, Fujimoto M, Matsuzaki S, Egawa-Takata T, Kobayashi E, Ueda Y, Morii E, Enomoto T, Naka T, Kimura T) 114/5, 554-561 201603 () 10.1038/bjc.2016.27

Myeloid cell-derived LRG attenuates adverse cardiac remodelling after myocardial infarction.
 Cardiovascular research (Kumagai S, Nakayama H, Fujimoto M, Honda H, Serada S, Ishibashi-Ueda H, Kasai A, Obana M, Sakata Y, Sawa Y, Fujio Y, Naka T) 109/2, 272-282 201602 () 10.1093/cvr/cvv273

Human herpesvirus 6 U11 protein is critical for virus infection.
 Virology (Mahmoud NF, Kawabata A, Tang H, Wakata A, Wang B, Serada S, Naka T, Mori Y) 489/, 151-157 201602 () 10.1016/j.virol.2015.12.011

Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling.
 Scientific reports (Yamada K, Miyamoto Y, Tsujii A, Moriyama T, Ikuno Y, Shiromizu T, Serada S, Fujimoto M, Tomonaga T, Naka T, Yoneda Y, Oka M) 6/, 21410 201602 () 10.1038/srep21410

Detecting Secondary C-KIT Mutations in the Peripheral Blood of Patients with Imatinib-Resistant Gastrointestinal Stromal Tumor.
 Oncology (Wada N, Kurokawa Y, Takahashi T, Hamakawa T, Hirota S, Naka T, Miyazaki Y, Makino T, Yamasaki M, Nakajima K, Takiguchi S, Mori M, Doki Y) 90/2, 112-117 2016 () 10.1159/000442948

Interleukin-6 Deficiency Does Not Affect Motor Neuron Disease Caused by Superoxide Dismutase 1 Mutation.
 PloS one (Han Y, Ripley B, Serada S, Naka T, Fujimoto M) 11/4, e0153399 2016 () 10.1371/journal.pone.0153399

Sputum Leucine-Rich Alpha-2 Glycoprotein as a Marker of Airway Inflammation in Asthma.
 PloS one (Honda H, Fujimoto M, Miyamoto S, Ishikawa N, Serada S, Hattori N, Nomura S, Kohno N, Yokoyama A, Naka T) 11/9, e0162672 2016 () 10.1371/journal.pone.0162672

Suppressor of cytokine signalling-1 induces significant preclinical antitumor effect in malignant melanoma cells.
 Experimental dermatology (Tagami-Nagata N, Serada S, Fujimoto M, Tanemura A, Nakatsuka R, Ohkawara T, Murota H, Kishimoto T, Katayama I, Naka T) 24/11, 864-871 201511 () 10.1111/exd.12802

CTLA4-Ig suppresses development of experimental autoimmune uveitis in the induction and effector phases: Comparison with blockade of interleukin-6.
 Experimental eye research (Iwahashi C, Fujimoto M, Nomura S, Serada S, Nakai K, Ohguro N, Nishida K, Naka T) 140/, 53-64 201511 () 10.1016/j.exer.2015.08.012

CpG oligodeoxynucleotides potentiate the antitumor activity of anti-BST2 antibody.
 Cancer science (Hiramatsu K, Serada S, Kobiyama K, Nakagawa S, Morimoto A, Matsuzaki S, Ueda Y, Fujimoto M, Yoshino K, Ishii KJ, Enomoto T, Kimura T, Naka T) 106/10, 1474-1478 201510 () 10.1111/cas.12738

Gene therapy with SOCS1 for gastric cancer induces G2/M arrest and has an antitumour effect on peritoneal carcinomatosis.
 British journal of cancer (Natatsuka R, Takahashi T, Serada S, Fujimoto M, Ookawara T, Nishida T, Hara H, Nishigaki T, Harada E, Murakami T, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Kishimoto T, Mori M, Doki Y, Naka T) 113/3, 433-442 201507 () 10.1038/bjc.2015.229

Salt-inducible kinase 3 deficiency exacerbates lipopolysaccharide-induced endotoxin shock accompanied by increased levels of pro-inflammatory molecules in mice.
 Immunology (Sanosaka M, Fujimoto M, Ohkawara T, Nagatake T, Itoh Y, Kagawa M, Kumagai A, Fuchino H, Kunisawa J, Naka T, Takemori H) 145/2, 268-278 201506 () 10.1111/imm.12445

Leucine-rich α-2-glycoprotein promotes TGFβ1-mediated growth suppression in the Lewis lung carcinoma cell lines.
 Oncotarget (Takemoto N, Serada S, Fujimoto M, Honda H, Ohkawara T, Takahashi T, Nomura S, Inohara H, Naka T) 6/13, 11009-11022 201505 () 10.18632/oncotarget.3557

Leucine-rich α2 -glycoprotein as a potential biomarker for joint inflammation during anti-interleukin-6 biologic therapy in rheumatoid arthritis.
 Arthritis & rheumatology (Hoboken, N.J.) (Fujimoto M, Serada S, Suzuki K, Nishikawa A, Ogata A, Nanki T, Hattori K, Kohsaka H, Miyasaka N, Takeuchi T, Naka T) 67/8, 2056-2060 201505 () 10.1002/art.39164

Proteomic identification of heterogeneous nuclear ribonucleoprotein K as a novel cold-associated autoantigen in patients with secondary Raynaud's phenomenon.
 Rheumatology (Oxford, England) (Yang L, Fujimoto M, Murota H, Serada S, Fujimoto M, Honda H, Yamada K, Suzuki K, Nishikawa A, Hosono Y, Yoneda Y, Takehara K, Imura Y, Mimori T, Takeuchi T, Katayama I, Naka T) 54/2, 349-358 201502 () 10.1093/rheumatology/keu325

Clinicopathological Significance of Leucine-Rich α2-Glycoprotein-1 in Sera of Patients With Pancreatic Cancer.
 Pancreas (Furukawa K, Kawamoto K, Eguchi H, Tanemura M, Tanida T, Tomimaru Y, Akita H, Hama N, Wada H, Kobayashi S, Nonaka Y, Takamatsu S, Shinzaki S, Kumada T, Satomura S, Ito T, Serada S, Naka T, Mori M, Doki Y, Miyoshi E, Nagano H) 44/1, 93-98 201501 () 10.1097/MPA.0000000000000205

Human herpesvirus 6 gM/gN complex interacts with v-SNARE in infected cells.
 The Journal of general virology (Kawabata A, Serada S, Naka T, Mori Y) 95/Pt 12, 2769-2777 201412 () 10.1099/vir.0.069336-0

Identification of sialylated glycoproteins in Doxorubicin-treated hepatoma cells with glycoproteomic analyses.
 Journal of proteome research (Azuma K, Serada S, Takamatsu S, Terao N, Takeishi S, Kamada Y, Naka T, Miyoshi E) 13/11, 4869-4877 201411 () 10.1021/pr5004399

Annexin A4 induces platinum resistance in a chloride-and calcium-dependent manner.
 Oncotarget (Morimoto A, Serada S, Enomoto T, Kim A, Matsuzaki S, Takahashi T, Ueda Y, Yoshino K, Fujita M, Fujimoto M, Kimura T, Naka T) 5/17, 7776-7787 201409 () 10.18632/oncotarget.2306

Histamine contributes to tissue remodeling via periostin expression.
 The Journal of investigative dermatology (Yang L, Murota H, Serada S, Fujimoto M, Kudo A, Naka T, Katayama I) 134/8, 2105-2113 201408 () 10.1038/jid.2014.120

Periostin accelerates human malignant melanoma progression by modifying the melanoma microenvironment.
 Pigment cell & melanoma research (Kotobuki Y, Yang L, Serada S, Tanemura A, Yang F, Nomura S, Kudo A, Izuhara K, Murota H, Fujimoto M, Katayama I, Naka T) 27/4, 630-639 201407 () 10.1111/pcmr.12245

The translation elongation factor eEF2 is a novel tumor?associated antigen overexpressed in various types of cancers.
 International journal of oncology (Oji Y, Tatsumi N, Fukuda M, Nakatsuka S, Aoyagi S, Hirata E, Nanchi I, Fujiki F, Nakajima H, Yamamoto Y, Shibata S, Nakamura M, Hasegawa K, Takagi S, Fukuda I, Hoshikawa T, Murakami Y, Mori M, Inoue M, Naka T, Tomonaga T, Shimizu Y, Nakagawa M, Hasegawa J, Nezu R, Inohara H, Izumoto S, Nonomura N, Yoshimine T, Okumura M, Morii E, Maeda H, Nishida S, Hosen N, Tsuboi A, Oka Y, Sugiyama H) 44/5, 1461-1469 201405 () 10.3892/ijo.2014.2318

Annexin A4-conferred platinum resistance is mediated by the copper transporter ATP7A.
 International journal of cancer (Matsuzaki S, Enomoto T, Serada S, Yoshino K, Nagamori S, Morimoto A, Yokoyama T, Kim A, Kimura T, Ueda Y, Fujita M, Fujimoto M, Kanai Y, Kimura T, Naka T) 134/8, 1796-1809 201404 () 10.1002/ijc.28526

Annexin A4 is a promising therapeutic target for the treatment of platinum-resistant cancers.
 Expert opinion on therapeutic targets (Matsuzaki S, Serada S, Morimoto A, Ueda Y, Yoshino K, Kimura T, Naka T) 18/4, 403-414 201404 () 10.1517/14728222.2014.882323

MHC class I molecules are incorporated into human herpesvirus-6 viral particles and released into the extracellular environment.
 Microbiology and immunology (Ota M, Serada S, Naka T, Mori Y) 58/2, 119-125 201402 () 10.1111/1348-0421.12121

Expression of MHC class I molecule in HHV-6B-infected cells.
 Microbiology and immunology (Ota M, Serada S, Naka T, Mori Y) 58/2, Februarycover 201402 () 10.1111/1348-0421.12142

Varicella-zoster virus ORF49 functions in the efficient production of progeny virus through its interaction with essential tegument protein ORF44.
 Journal of virology (Sadaoka T, Serada S, Kato J, Hayashi M, Gomi Y, Naka T, Yamanishi K, Mori Y) 88/1, 188-201 201401 () 10.1128/JVI.02245-13

Screening for novel serum biomarker for monitoring disease activity in rheumatoid arthritis using iTRAQ technology-based quantitative proteomic approach.
 Methods in molecular biology (Clifton, N.J.) (Serada S, Naka T) 1142/, 99-110 2014 () 10.1007/978-1-4939-0404-4_12

New findings of kinase switching in gastrointestinal stromal tumor under imatinib using phosphoproteomic analysis.
 International journal of cancer (Takahashi T, Serada S, Ako M, Fujimoto M, Miyazaki Y, Nakatsuka R, Ikezoe T, Yokoyama A, Taguchi T, Shimada K, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Mori M, Doki Y, Naka T, Nishida T) 133/11, 2737-2743 201312 () 10.1002/ijc.28282

Molecular mechanism underlying the antiproliferative effect of suppressor of cytokine signaling-1 in non-small-cell lung cancer cells.
 Cancer science (Shimada K, Serada S, Fujimoto M, Nomura S, Nakatsuka R, Harada E, Iwahori K, Tachibana I, Takahashi T, Kumanogoh A, Kishimoto T, Naka T) 104/11, 1483-1491 201311 () 10.1111/cas.12266

CD34?/CD38? acute myelogenous leukemia cells aberrantly express CD82 which regulates adhesion and survival of leukemia stem cells.
 International journal of cancer (Nishioka C, Ikezoe T, Furihata M, Yang J, Serada S, Naka T, Nobumoto A, Kataoka S, Tsuda M, Udaka K, Yokoyama A) 132/9, 2006-2019 201305 () 10.1002/ijc.27904

CD134 is a cellular receptor specific for human herpesvirus-6B entry.
 Proceedings of the National Academy of Sciences of the United States of America (Tang H, Serada S, Kawabata A, Ota M, Hayashi E, Naka T, Yamanishi K, Mori Y) 110/22, 9096-9099 201305 () 10.1073/pnas.1305187110

Substrate-attached materials are enriched with tetraspanins and are analogous to the structures associated with rear-end retraction in migrating cells.
 Cell adhesion & migration (Yamada M, Mugnai G, Serada S, Yagi Y, Naka T, Sekiguchi K) 7/3, 304-314 201305 () 10.4161/cam.25041

Lectin-based immunoassay for aberrant IgG glycosylation as the biomarker for Crohn's disease.
 Inflammatory bowel diseases (Shinzaki S, Kuroki E, Iijima H, Tatsunaka N, Ishii M, Fujii H, Kamada Y, Kobayashi T, Shibukawa N, Inoue T, Tsujii M, Takeishi S, Mizushima T, Ogata A, Naka T, Plevy SE, Takehara T, Miyoshi E) 19/2, 321-331 201302 () 10.1097/MIB.0b013e318280eade

SOCS-1 gene delivery cooperates with cisplatin plus pemetrexed to exhibit preclinical antitumor activity against malignant pleural mesothelioma.
 International journal of cancer (Iwahori K, Serada S, Fujimoto M, Ripley B, Nomura S, Mizuguchi H, Shimada K, Takahashi T, Kawase I, Kishimoto T, Naka T) 132/2, 459-471 201301 () 10.1002/ijc.27611

Plasma membrane proteomics identifies bone marrow stromal antigen 2 as a potential therapeutic target in endometrial cancer.
 International journal of cancer (Yokoyama T, Enomoto T, Serada S, Morimoto A, Matsuzaki S, Ueda Y, Yoshino K, Fujita M, Kyo S, Iwahori K, Fujimoto M, Kimura T, Naka T) 132/2, 472-484 201301 () 10.1002/ijc.27679

Calretinin mediates apoptosis in small cell lung cancer cells expressing tetraspanin CD9.
 FEBS open bio (He P, Kuhara H, Tachibana I, Jin Y, Takeda Y, Tetsumoto S, Minami T, Kohmo S, Hirata H, Takahashi R, Inoue K, Nagatomo I, Kida H, Kijima T, Naka T, Morii E, Kawase I, Kumanogoh A) 3/, 225-230 2013 () 10.1016/j.fob.2013.04.005

Karyopherin alpha2 is essential for rRNA transcription and protein synthesis in proliferative keratinocytes.
 PloS one (Umegaki-Arao N, Tamai K, Nimura K, Serada S, Naka T, Nakano H, Katayama I) 8/10, e76416 2013 () 10.1371/journal.pone.0076416

Serum leucine-rich alpha-2 glycoprotein is a disease activity biomarker in ulcerative colitis.
 Inflammatory bowel diseases (Serada S, Fujimoto M, Terabe F, Iijima H, Shinzaki S, Matsuzaki S, Ohkawara T, Nezu R, Nakajima S, Kobayashi T, Plevy SE, Takehara T, Naka T) 18/11, 2169-2179 201211 () 10.1002/ibd.22936

Antiproliferative effect of SOCS-1 through the suppression of STAT3 and p38 MAPK activation in gastric cancer cells.
 International journal of cancer (Souma Y, Nishida T, Serada S, Iwahori K, Takahashi T, Fujimoto M, Ripley B, Nakajima K, Miyazaki Y, Mori M, Doki Y, Sawa Y, Naka T) 131/6, 1287-1296 201209 () 10.1002/ijc.27350

Serum HE4 as a diagnostic and prognostic marker for lung cancer.
 Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Iwahori K, Suzuki H, Kishi Y, Fujii Y, Uehara R, Okamoto N, Kobayashi M, Hirashima T, Kawase I, Naka T) 33/4, 1141-1149 201208 () 10.1007/s13277-012-0356-9

Suppressor of cytokine signaling 1 DNA administration inhibits inflammatory and pathogenic responses in autoimmune myocarditis.
 Journal of immunology (Baltimore, Md. : 1950) (Tajiri K, Imanaka-Yoshida K, Matsubara A, Tsujimura Y, Hiroe M, Naka T, Shimojo N, Sakai S, Aonuma K, Yasutomi Y) 189/4, 2043-2053 201208 () 10.4049/jimmunol.1103610

Periostin, a matricellular protein, accelerates cutaneous wound repair by activating dermal fibroblasts.
 Experimental dermatology (Ontsuka K, Kotobuki Y, Shiraishi H, Serada S, Ohta S, Tanemura A, Yang L, Fujimoto M, Arima K, Suzuki S, Murota H, Toda S, Kudo A, Conway SJ, Narisawa Y, Katayama I, Izuhara K, Naka T) 21/5, 331-336 201205 () 10.1111/j.1600-0625.2012.01454.x

Dysregulation of melanocyte function by Th17-related cytokines: significance of Th17 cell infiltration in autoimmune vitiligo vulgaris.
 Pigment cell & melanoma research (Kotobuki Y, Tanemura A, Yang L, Itoi S, Wataya-Kaneda M, Murota H, Fujimoto M, Serada S, Naka T, Katayama I) 25/2, 219-230 201203 () 10.1111/j.1755-148X.2011.00945.x

Therapeutic strategies in epithelial ovarian cancer.
 Journal of experimental & clinical cancer research : CR (Kim A, Ueda Y, Naka T, Enomoto T) 31/, 14 201202 () 10.1186/1756-9966-31-14

Blockade of interleukin-6 receptor alleviates disease in mouse model of scleroderma.
 The American journal of pathology (Kitaba S, Murota H, Terao M, Azukizawa H, Terabe F, Shima Y, Fujimoto M, Tanaka T, Naka T, Kishimoto T, Katayama I) 180/1, 165-176 201201 () 10.1016/j.ajpath.2011.09.013

Involvement of SIK3 in glucose and lipid homeostasis in mice.
 PloS one (Uebi T, Itoh Y, Hatano O, Kumagai A, Sanosaka M, Sasaki T, Sasagawa S, Doi J, Tatsumi K, Mitamura K, Morii E, Aozasa K, Kawamura T, Okumura M, Nakae J, Takikawa H, Fukusato T, Koura M, Nish M, Hamsten A, Silveira A, Bertorello AM, Kitagawa K, Nagaoka Y, Kawahara H, Tomonaga T, Naka T, Ikegawa S, Tsumaki N, Matsuda J, Takemori H) 7/5, e37803 2012 () 10.1371/journal.pone.0037803

Periostin facilitates skin sclerosis via PI3K/Akt dependent mechanism in a mouse model of scleroderma.
 PloS one (Yang L, Serada S, Fujimoto M, Terao M, Kotobuki Y, Kitaba S, Matsui S, Kudo A, Naka T, Murota H, Katayama I) 7/7, e41994 2012 () 10.1371/journal.pone.0041994

IL-6-mediated Th17 differentiation through RORγt is essential for the initiation of experimental autoimmune myocarditis.
 Cardiovascular research (Yamashita T, Iwakura T, Matsui K, Kawaguchi H, Obana M, Hayama A, Maeda M, Izumi Y, Komuro I, Ohsugi Y, Fujimoto M, Naka T, Kishimoto T, Nakayama H, Fujio Y) 91/4, 640-648 201109 () 10.1093/cvr/cvr148

Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma.
 International journal of cancer (Iwahori K, Serada S, Fujimoto M, Nomura S, Osaki T, Lee CM, Mizuguchi H, Takahashi T, Ripley B, Okumura M, Kawase I, Kishimoto T, Naka T) 129/4, 1005-1017 201108 () 10.1002/ijc.25716

Blockade of interleukin-6 signaling suppresses not only th17 but also interphotoreceptor retinoid binding protein-specific Th1 by promoting regulatory T cells in experimental autoimmune uveoretinitis.
 Investigative ophthalmology & visual science (Haruta H, Ohguro N, Fujimoto M, Hohki S, Terabe F, Serada S, Nomura S, Nishida K, Kishimoto T, Naka T) 52/6, 3264-3271 201105 () 10.1167/iovs.10-6272

Comparative analysis of the effects of anti-IL-6 receptor mAb and anti-TNF mAb treatment on CD4+ T-cell responses in murine colitis.
 Inflammatory bowel diseases (Terabe F, Fujimoto M, Serada S, Shinzaki S, Iijima H, Tsujii M, Hayashi N, Nomura S, Kawahata H, Jang MH, Miyasaka M, Mihara M, Ohsugi Y, Kishimoto T, Naka T) 17/2, 491-502 201102 () 10.1002/ibd.21384

Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice.
 Journal of controlled release : official journal of the Controlled Release Society (Nomura T, Abe Y, Kamada H, Shibata H, Kayamuro H, Inoue M, Kawara T, Arita S, Furuya T, Yamashita T, Nagano K, Yoshikawa T, Yoshioka Y, Mukai Y, Nakagawa S, Taniai M, Ohta T, Serada S, Naka T, Tsunoda S, Tsutsumi Y) 149/1, 44057 201101 () 10.1016/j.jconrel.2009.12.015

Reprint of: Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines: Programmed endosomal escape and dissociation.
 Journal of controlled release : official journal of the Controlled Release Society (Akita H, Kogure K, Moriguchi R, Nakamura Y, Higashi T, Nakamura T, Serada S, Fujimoto M, Naka T, Futaki S, Harashima H) 149/1, 58-64 201101 () 10.1016/j.jconrel.2010.08.023

The influence of excessive IL-6 production in vivo on the development and function of Foxp3+ regulatory T cells.
 Journal of immunology (Baltimore, Md. : 1950) (Fujimoto M, Nakano M, Terabe F, Kawahata H, Ohkawara T, Han Y, Ripley B, Serada S, Nishikawa T, Kimura A, Nomura S, Kishimoto T, Naka T) 186/1, 32-40 201101 () 10.4049/jimmunol.0903314

Targeting annexin A4 to counteract chemoresistance in clear cell carcinoma of the ovary.
 Expert opinion on therapeutic targets (Kim A, Serada S, Enomoto T, Naka T) 14/9, 963-971 201009 () 10.1517/14728222.2010.511180

Blockade of interleukin-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Th17 responses.
 Experimental eye research (Hohki S, Ohguro N, Haruta H, Nakai K, Terabe F, Serada S, Fujimoto M, Nomura S, Kawahata H, Kishimoto T, Naka T) 91/2, 162-170 201008 () 10.1016/j.exer.2010.04.009

Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines: programmed endosomal escape and dissociation.
 Journal of controlled release : official journal of the Controlled Release Society (Akita H, Kogure K, Moriguchi R, Nakamura Y, Higashi T, Nakamura T, Serada S, Fujimoto M, Naka T, Futaki S, Harashima H) 143/3, 311-317 201005 () 10.1016/j.jconrel.2010.01.012

Green tea polyphenol epigallocatechin gallate inhibits cell signaling by inducing SOCS1 gene expression.
 International immunology (Ripley BJ, Fujimoto M, Serada S, Ohkawara T, Nishikawa T, Terabe F, Matsukawa Y, Stephanou A, Knight RA, Isenberg DA, Latchman DS, Kishimoto T, Naka T) 22/5, 359-366 201005 () 10.1093/intimm/dxq015

iTRAQ-based proteomic identification of leucine-rich alpha-2 glycoprotein as a novel inflammatory biomarker in autoimmune diseases.
 Annals of the rheumatic diseases (Serada S, Fujimoto M, Ogata A, Terabe F, Hirano T, Iijima H, Shinzaki S, Nishikawa T, Ohkawara T, Iwahori K, Ohguro N, Kishimoto T, Naka T) 69/4, 770-774 201004 () 10.1136/ard.2009.118919

Brain volume analyses and somatosensory evoked potentials in multiple system atrophy.
 Journal of neurology (Miyatake S, Mochizuki H, Naka T, Ugawa Y, Tanabe H, Kuzume D, Suzuki M, Ogata K, Kawai M) 257/3, 419-425 201003 () 10.1007/s00415-009-5338-5

SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses, in Human Liver Diseases.
 Gastroenterology research and practice (Fujimoto M, Naka T) 2010/, 2010 () 10.1155/2010/470468

Natural occurring IL-17 producing T cells regulate the initial phase of neutrophil mediated airway responses.
 Journal of immunology (Baltimore, Md. : 1950) (Tanaka S, Yoshimoto T, Naka T, Nakae S, Iwakura Y, Cua D, Kubo M) 183/11, 7523-7530 200912 () 10.4049/jimmunol.0803828

Enhanced expression of Annexin A4 in clear cell carcinoma of the ovary and its association with chemoresistance to carboplatin.
 International journal of cancer (Kim A, Enomoto T, Serada S, Ueda Y, Takahashi T, Ripley B, Miyatake T, Fujita M, Lee CM, Morimoto K, Fujimoto M, Kimura T, Naka T) 125/10, 2316-2322 200911 () 10.1002/ijc.24587

Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses.
 The Journal of experimental medicine (Kimura A, Naka T, Nakahama T, Chinen I, Masuda K, Nohara K, Fujii-Kuriyama Y, Kishimoto T) 206/9, 2027-2035 200908 () 10.1084/jem.20090560

Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses.
 Arthritis and rheumatism (Fujimoto M, Serada S, Mihara M, Uchiyama Y, Yoshida H, Koike N, Ohsugi Y, Nishikawa T, Ripley B, Kimura A, Kishimoto T, Naka T) 58/12, 3710-3719 200812 () 10.1002/art.24126

Megakaryocyte potentiating factor as a tumor marker of malignant pleural mesothelioma: evaluation in comparison with mesothelin.
 Lung cancer (Amsterdam, Netherlands) (Iwahori K, Osaki T, Serada S, Fujimoto M, Suzuki H, Kishi Y, Yokoyama A, Hamada H, Fujii Y, Yamaguchi K, Hirashima T, Matsui K, Tachibana I, Nakamura Y, Kawase I, Naka T) 62/1, 45-54 200810 () 10.1016/j.lungcan.2008.02.012

Aberrant expression of glycosylation in juvenile gastrointestinal stromal tumors.
 Proteomics. Clinical applications (Takahashi T, Naka T, Fujimoto M, Serada S, Horino J, Terabe F, Hirota S, Miyoshi E, Hirai T, Nakajima K, Nishitani A, Souma Y, Sawa Y, Nishida T) 2/9, 1246-1254 200809 () 10.1002/prca.200700119

IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis.
 Proceedings of the National Academy of Sciences of the United States of America (Serada S, Fujimoto M, Mihara M, Koike N, Ohsugi Y, Nomura S, Yoshida H, Nishikawa T, Terabe F, Ohkawara T, Takahashi T, Ripley B, Kimura A, Kishimoto T, Naka T) 105/26, 9041-9046 200807 () 10.1073/pnas.0802218105

SOCS1 regulates CCR7 expression and migration of CD4+ T cells into peripheral tissues.
 Journal of immunology (Baltimore, Md. : 1950) (Yu CR, Mahdi RM, Liu X, Zhang A, Naka T, Kishimoto T, Egwuagu CE) 181/2, 1190-1198 200807 ()

Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells.
 Proceedings of the National Academy of Sciences of the United States of America (Kimura A, Naka T, Nohara K, Fujii-Kuriyama Y, Kishimoto T) 105/28, 9721-9726 200807 () 10.1073/pnas.0804231105

Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice.
 International immunology (Horino J, Fujimoto M, Terabe F, Serada S, Takahashi T, Soma Y, Tanaka K, Chinen T, Yoshimura A, Nomura S, Kawase I, Hayashi N, Kishimoto T, Naka T) 20/6, 753-762 200806 () 10.1093/intimm/dxn033

Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus.
 Journal of leukocyte biology (Yamaguchi H, Takagi J, Miyamae T, Yokota S, Fujimoto T, Nakamura S, Ohshima S, Naka T, Nagata S) 83/5, 1300-1307 200805 () 10.1189/jlb.1107730

Suppressor of cytokine signaling 1 inhibits pulmonary inflammation and fibrosis.
 The Journal of allergy and clinical immunology (Nakashima T, Yokoyama A, Onari Y, Shoda H, Haruta Y, Hattori N, Naka T, Kohno N) 121/5, 1269-1276 200805 () 10.1016/j.jaci.2008.02.003

[Role of IL-6 in the development and pathogenesis of CIA and EAE].
 Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology (Fujimoto M, Serada S, Naka T) 31/2, 78-84 200804 () 10.2177/jsci.31.78

Transcriptional complex formation of c-Fos, STAT3, and hepatocyte NF-1 alpha is essential for cytokine-driven C-reactive protein gene expression.
 Journal of immunology (Baltimore, Md. : 1950) (Nishikawa T, Hagihara K, Serada S, Isobe T, Matsumura A, Song J, Tanaka T, Kawase I, Naka T, Yoshizaki K) 180/5, 3492-3501 200803 ()

Demonstration of cooperative contribution of MET- and EGFR-mediated STAT3 phosphorylation to liver regeneration by exogenous suppressor of cytokine signalings.
 Journal of hepatology (Seki E, Kondo Y, Iimuro Y, Naka T, Son G, Kishimoto T, Fujimoto J, Tsutsui H, Nakanishi K) 48/2, 237-245 200802 () 10.1016/j.jhep.2007.08.020

Proteomics-based identification of alpha-enolase as a tumor antigen in non-small lung cancer.
 Cancer science (He P, Naka T, Serada S, Fujimoto M, Tanaka T, Hashimoto S, Shima Y, Yamadori T, Suzuki H, Hirashima T, Matsui K, Shiono H, Okumura M, Nishida T, Tachibana I, Norioka N, Norioka S, Kawase I) 98/8, 1234-1240 200708 () 10.1111/j.1349-7006.2007.00509.x

IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells.
 Proceedings of the National Academy of Sciences of the United States of America (Kimura A, Naka T, Kishimoto T) 104/29, 12099-12104 200707 () 10.1073/pnas.0705268104

SOCS proteins, cytokine signalling and immune regulation.
 Nature reviews. Immunology (Yoshimura A, Naka T, Kubo M) 7/6, 454-465 200706 () 10.1038/nri2093

Effects of pioglitazone on suppressor of cytokine signaling 3 expression: potential mechanisms for its effects on insulin sensitivity and adiponectin expression.
 Diabetes (Kanatani Y, Usui I, Ishizuka K, Bukhari A, Fujisaka S, Urakaze M, Haruta T, Kishimoto T, Naka T, Kobayashi M) 56/3, 795-803 200703 () 10.2337/db06-1039

Overproduction of collagen and diminished SOCS1 expression are causally linked in fibroblasts from idiopathic pulmonary fibrosis.
 Biochemical and biophysical research communications (Shoda H, Yokoyama A, Nishino R, Nakashima T, Ishikawa N, Haruta Y, Hattori N, Naka T, Kohno N) 353/4, 1004-1010 200702 () 10.1016/j.bbrc.2006.12.128

Proteomic analysis of autoantigens associated with systemic lupus erythematosus: Anti-aldolase A antibody as a potential marker of lupus nephritis.
 Proteomics. Clinical applications (Serada S, Fujimoto M, Takahashi T, He P, Hayashi A, Tanaka T, Hagihara K, Yamadori T, Mochizuki M, Norioka N, Norioka S, Kawase I, Naka T) 1/2, 185-191 200702 () 10.1002/prca.200600497

Overexpression of PIAS3 suppresses cell growth and restores the drug sensitivity of human lung cancer cells in association with PI3-K/Akt inactivation.
 Neoplasia (New York, N.Y.) (Ogata Y, Osaki T, Naka T, Iwahori K, Furukawa M, Nagatomo I, Kijima T, Kumagai T, Yoshida M, Tachibana I, Kawase I) 8/10, 817-825 200610 () 10.1593/neo.06409

SOCS-2 interferes with myotube formation and potentiates osteoblast differentiation through upregulation of JunB in C2C12 cells.
 Journal of cellular physiology (Ouyang X, Fujimoto M, Nakagawa R, Serada S, Tanaka T, Nomura S, Kawase I, Kishimoto T, Naka T) 207/2, 428-436 200605 () 10.1002/jcp.20579

IL-18 gene polymorphisms affect IL-18 production capability by monocytes.
 Biochemical and biophysical research communications (Arimitsu J, Hirano T, Higa S, Kawai M, Naka T, Ogata A, Shima Y, Fujimoto M, Yamadori T, Hagiwara K, Ohgawara T, Kuwabara Y, Kawase I, Tanaka T) 342/4, 1413-1416 200604 () 10.1016/j.bbrc.2006.02.096

Luteolin, a flavonoid, inhibits AP-1 activation by basophils.
 Biochemical and biophysical research communications (Hirano T, Higa S, Arimitsu J, Naka T, Ogata A, Shima Y, Fujimoto M, Yamadori T, Ohkawara T, Kuwabara Y, Kawai M, Matsuda H, Yoshikawa M, Maezaki N, Tanaka T, Kawase I, Tanaka T) 340/1, 43837 200602 () 10.1016/j.bbrc.2005.11.157

Luteolin, a flavonoid, inhibits CD40 ligand expression by activated human basophils.
 International archives of allergy and immunology (Hirano T, Arimitsu J, Higa S, Naka T, Ogata A, Shima Y, Fujimoto M, Yamadori T, Ohkawara T, Kuwabara Y, Kawai M, Kawase I, Tanaka T) 140/2, 150-156 2006 () 10.1159/000092554

Osteoblast differentiation is impaired in SOCS-1-deficient mice.
 Journal of bone and mineral metabolism (Abe T, Nomura S, Nakagawa R, Fujimoto M, Kawase I, Naka T) 24/4, 283-290 2006 () 10.1007/s00774-006-0685-0

Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT.
 Proceedings of the National Academy of Sciences of the United States of America (Kimura A, Naka T, Muta T, Takeuchi O, Akira S, Kawase I, Kishimoto T) 102/47, 17089-17094 200511 () 10.1073/pnas.0508517102

Suppressor of cytokine signaling 1 suppresses muscle differentiation through modulation of IGF-I receptor signal transduction.
 Biochemical and biophysical research communications (Inaba M, Saito H, Fujimoto M, Sumitani S, Ohkawara T, Tanaka T, Kouhara H, Kasayama S, Kawase I, Kishimoto T, Naka T) 328/4, 953-961 200503 () 10.1016/j.bbrc.2005.01.046

Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration.
 Hepatology (Baltimore, Md.) (Seki E, Tsutsui H, Iimuro Y, Naka T, Son G, Akira S, Kishimoto T, Nakanishi K, Fujimoto J) 41/3, 443-450 200503 () 10.1002/hep.20603

Negative regulation of cytokine and TLR signalings by SOCS and others.
 Advances in immunology (Naka T, Fujimoto M, Tsutsui H, Yoshimura A) 87/, 61-122 2005 () 10.1016/S0065-2776(05)87003-8

Implication of SOCS-1 gene methylation in acute myeloid leukaemia.
 British journal of haematology (Watanabe D, Naka T, Kishimoto T) 127/5, 608-609 200412 () 10.1111/j.1365-2141.2004.05245.x

Suppressor of cytokine signalling-1 gene silencing in acute myeloid leukaemia and human haematopoietic cell lines.
 British journal of haematology (Watanabe D, Ezoe S, Fujimoto M, Kimura A, Saito Y, Nagai H, Tachibana I, Matsumura I, Tanaka T, Kanegane H, Miyawaki T, Emi M, Kanakura Y, Kawase I, Naka T, Kishimoto T) 126/5, 726-735 200409 () 10.1111/j.1365-2141.2004.05107.x

SOCS-1 suppresses TNF-alpha-induced apoptosis through the regulation of Jak activation.
 International immunology (Kimura A, Naka T, Nagata S, Kawase I, Kishimoto T) 16/7, 991-999 200407 () 10.1093/intimm/dxh102

Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils.
 International archives of allergy and immunology (Hirano T, Higa S, Arimitsu J, Naka T, Shima Y, Ohshima S, Fujimoto M, Yamadori T, Kawase I, Tanaka T) 134/2, 135-140 200406 () 10.1159/000078498

Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers.
 Japanese journal of clinical oncology (Komazaki T, Nagai H, Emi M, Terada Y, Yabe A, Jin E, Kawanami O, Konishi N, Moriyama Y, Naka T, Kishimoto T) 34/4, 191-194 200404 () 10.1093/jjco/hyh035

Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases.
 International immunology (Fujimoto M, Tsutsui H, Xinshou O, Tokumoto M, Watanabe D, Shima Y, Yoshimoto T, Hirakata H, Kawase I, Nakanishi K, Kishimoto T, Naka T) 16/2, 303-314 200402 () 10.1093/intimm/dxh030

Regulation of cytokine signaling by SOCS family molecules.
 Trends in immunology (Fujimoto M, Naka T) 24/12, 659-666 200312 () 10.1016/j.it.2003.10.008

Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas.
 Journal of human genetics (Nagai H, Naka T, Terada Y, Komazaki T, Yabe A, Jin E, Kawanami O, Kishimoto T, Konishi N, Nakamura M, Kobayashi Y, Emi M) 48/2, 65-69 2003 () 10.1007/s100380300008

A regulatory role for suppressor of cytokine signaling-1 in T(h) polarization in vivo.
 International immunology (Fujimoto M, Tsutsui H, Yumikura-Futatsugi S, Ueda H, Xingshou O, Abe T, Kawase I, Nakanishi K, Kishimoto T, Naka T) 14/11, 1343-1350 200211 () 10.1093/intimm/dxf094

SOCS-1 participates in negative regulation of LPS responses.
 Immunity (Nakagawa R, Naka T, Tsutsui H, Fujimoto M, Kimura A, Abe T, Seki E, Sato S, Takeuchi O, Takeda K, Akira S, Yamanishi K, Kawase I, Nakanishi K, Kishimoto T) 17/5, 677-687 200211 () 10.1016/S1074-7613(02)00449-1

Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation.
 Proceedings of the National Academy of Sciences of the United States of America (Seki Y, Hayashi K, Matsumoto A, Seki N, Tsukada J, Ransom J, Naka T, Kishimoto T, Yoshimura A, Kubo M) 99/20, 13003-13008 200210 () 10.1073/pnas.202477099

Infiltrating eosinophils and eotaxin: their association with idiopathic eosinophilic esophagitis.
 Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology (Fujiwara H, Morita A, Kobayashi H, Hamano K, Fujiwara Y, Hirai K, Yano M, Naka T, Saeki Y) 89/4, 429-432 200210 () 10.1016/S1081-1206(10)62047-9

Activation of signal transducer and activator transcription 3 and expression of suppressor of cytokine signal 1 during liver regeneration in rats.
 Journal of hepatology (Sakuda S, Tamura S, Yamada A, Miyagawa Ji, Yamamoto K, Kiso S, Ito N, Imanaka K, Wada A, Naka T, Kishimoto T, Kawata S, Matsuzawa Y) 36/3, 378-384 200203 () 10.1016/S0168-8278(01)00282-3

Joint disease caused by defective gp130-mediated STAT signaling.
 Arthritis research (Naka T, Kishimoto T) 4/3, 154-156 2002 () 10.1186/ar400

The paradigm of IL-6: from basic science to medicine.
 Arthritis research (Naka T, Nishimoto N, Kishimoto T) 4 Suppl 3/, S233-42 2002 () 10.1186/ar565

SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo.
 Immunity (Naka T, Tsutsui H, Fujimoto M, Kawazoe Y, Kohzaki H, Morita Y, Nakagawa R, Narazaki M, Adachi K, Yoshimoto T, Nakanishi K, Kishimoto T.) 14/5, 535-545 200105 () 10.1016/S1074-7613(01)00132-7

Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation.
 J Exp Med (Kawazoe Y, Naka T, Fujimoto M, Kohzaki H, Morita Y, Narazaki M, Okumura K, Saitoh H, Nakagawa R, Uchiyama Y, Akira S, Kishimoto T.) 193/2, 263-269 200101 () 10.1084/jem.193.2.263

Defective thymocyte development and perturbed homeostasis of T cells in STAT-induced STAT inhibitor-1/suppressors of cytokine signaling-1 transgenic mice.
 J Immunol (Fujimoto M, Naka T, Nakagawa R, Kawazoe Y, Morita Y, Tateishi A, Okumura K, Narazaki M, Kishimoto T.) 165/4, 1799-1806 200008 ()

IFN regulatory factor-1-mediated transcriptional activation of mouse STAT-induced STAT inhibitor-1 gene promoter by IFN-gamma.
 J Immunol (Saito H, Morita Y, Fujimoto M, Narazaki M, Naka T, Kishimoto T.) 164/11, 5833-5843 200006 ()

Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts.
 Proc Natl Acad Sci U S A (Morita Y, Naka T, Kawazoe Y, Fujimoto M, Narazaki M, Nakagawa R, Fukuyama H, Nagata S, Kishimoto T.) 97/10, 5405-5410 200005 () 10.1073/pnas.090084797

Negative regulation of cytokine signaling: STAT-induced STAT inhibitor.
 Trends Biochem Sci (Naka T, Fujimoto M, Kishimoto T.) 24/10, 394-398 199910 () 10.1016/S0968-0004(99)01454-1

Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice.
 Proc Natl Acad Sci U S A (Naka T, Matsumoto T, Narazaki M, Fujimoto M, Morita Y, Ohsawa Y, Saito H, Nagasawa T, Uchiyama Y, Kishimoto T.) 95/26, 15577-15582 199812 () 10.1073/pnas.95.26.15577

Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling.
 Proc Natl Acad Sci U S A (Narazaki M, Fujimoto M, Matsumoto T, Morita Y, Saito H, Kajita T, Yoshizaki K, Naka T, Kishimoto T.) 95/22, 13130-13134 199810 () 10.1073/pnas.95.22.13130

Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.
 Biochem Biophys Res Commun (Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T.) 237/1, 79-83 199708 () 10.1006/bbrc.1997.7080

Structure and function of a new STAT-induced STAT inhibitor.
 Nature (Naka T, Narazaki M, Hirata M, Matsumoto T, Minamoto S, Aono A, Nishimoto N, Kajita T, Taga T, Yoshizaki K, Akira S, Kishimoto T.) 387/6636, 924-929 199706 () 10.1038/43219

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