■ 氏名
湯浅 創 (ユアサ ハジメ)
YUASA Hajime

■ 所属部局/職名
Research and Education Faculty, Natural Sciences Cluster, Science and Technology Unit/Associate Professor
教育研究部 自然科学系 理工学部門/准教授

■ 学部・学科・コース等
Faculty of Science and Technology
理工学部 化学生命理工学科

■ 連絡先
住 所
電 話088-844-8690
F A X
E-Mailjulie●kochi-u.ac.jp    (送信の際は“●”を半角の“@”に変更して送信してください。)
U R L

■ 出身大学院・研究科等
東北大学 博士(理学研究科 生物学専攻) 1998 (修了)

■ 出身学校・専攻等
東北大学 (理学部 生物学科) 1992 (卒業)

■ 取得学位
博士(理学) (課程) 東北大学

■ 研究職歴

■ 委員歴・役員歴

■ 受賞学術賞

■ 所属学会
日本生化学会
 (評議員 2015〜 国内)
日本進化学会
 ( )
日本分子生物学会
 ( )

■ 専門分野
分子進化・生化学

■ 主な研究テーマ・活動
トリプトファン分解酵素の比較生化学と分子進化



■ 研究についてのPR

■ 社会人・生徒を対象として可能な講演・授業(例えば講演題目)
専門に関する演題

■ 研究業績(論文・解説)
A single amino acid residue regulates the substrate affinity and specificity of indoleamine 2,3-dioxygenase.
 Archives of Biochemistry and Biophysics (Yuasa, H.J., Sugiura, M., Harumoto, T.) 640/Feb 15, 1-9 2018 (学術雑誌) 10.1016/j.abb.2017.12.019

Novel Specificity of IDO Enzyme Involved in the Biosynthesis of Mating Pheromone in the Ciliate Blepharisma stoltei.
 Protist (Sugiura, M., Yuasa, H.J., Harumoto, T.) 168/6, 686-696 2017 (学術雑誌) 10.1016/j.protis.2017.09.003

High l-Trp affinity of indoleamine 2,3-dioxygenase 1 is attributed to two residues located in the distal heme pocket.
 FEBS Journal (Yuasa, H.J.) 283/19, 3651-3661 2016 (学術雑誌) 10.1111/febs.13834

Low efficiency IDO2 enzymes are conserved in lower vertebrates, whereas higher efficiency IDO1 enzymes are dispensable.
 FEBS Journal (Yuasa, H.J., Mizuno, K., Ball, H.J.) 282/14, 2735-2745 2015 (学術雑誌) 10.1111/febs.13316

Efficient tryptophan-catabolizing activity is consistently conserved through evolution of TDO enzymes, but not IDO enzymes.
 Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution (Yuasa, H.J., Ball, H.J.) 324/2, 128-140 2015 (学術雑誌) 10.1002/jez.b.22608

Tryptophan-catabolizing enzymes - party of three.
 Frontiers in Immunology (Ball, H.J., Fedelis, F.F., Bakmiwewa, S.M., Hunt, N.H., Yuasa, H.J.) 5/, article #485 2014 (学術雑誌) 10.3389/fimmu.2014.00485

Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1.
 Amino Acids (Pantouris, G., Sery, M., Yuasa, H.J., Ball, H.J., Mowat, C.G.) 46/9, 2155-2163 2014 (学術雑誌) 10.1007/s00726-014-1766-3

Indoleamine 2,3-dioxygenases with very low catalytic activity are well conserved across kingdoms: IDOs of Basidiomycota.
 Fungal Genetics and Biology (Yuasa, H.J., Ball, H.J.) 56/, 98-106 2013 (学術雑誌) 10.1016/j.fgb.2013.03.003

The evolution of three types of indoleamine 2,3 dioxygenases in fungi with distinct molecular and biochemical characteristics.
 Gene (Yuasa, H.J., Ball, H.J.) 504/1, 64-74 2012 (学術雑誌) 10.1016/j.gene.2012.04.082

Molecular evolution of bacterial indoleamine 2,3-dioxygenase.
 Gene (Yuasa, h.J., Ball, H.J.) 485/1, 22-31 2011 (学術雑誌) 10.1016/j.gene.2011.06.002

Molecular evolution and characterization of fungal indoleamine 2, 3-dioxygenases.
 Journal of Molecular Evolution (Yuasa, H.J., Ball, H.J.) 72/2, 160-168 2011 (学術雑誌) 10.1007/s00239-010-9412-5

1-L-Methyltryptophan is a more effective inhibitor of vertebrate IDO2 enzymes than 1-D-methyltryptophan.
 Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology (Yuasa, H.J., Ball, H.J., Austin, C.J.D., Hunt, N.H.) 157/1, 10-15 2010 (学術雑誌) 10.1016/j.cbpb.2010.04.006

Biochemical characteristics and inhibitor selectivity of mouse indoleamine 2,3-dioxygenase-2.
 Amino Acids (Austin, C.J.D., Mailu, B.M., Maghzal, G.J., Sanchez-Perez, A., Rahlfs, S., Zocher, K., Yuasa, H.J., Arthur, J.W., Becker, K., Stocker, R., Hunt, N.H., Ball, H.J. ) 39/2, 565-578 2010 (学術雑誌) 10.1007/s00726-010-0475-9

Characterization and evolution of vertebrate indoleamine 2, 3-dioxygenases. IDOs from monotremes and marsupials.
 Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology (Yuasa, H.J., Ball, H.J., Ho, Y.F., Austin, C.J.D., Whittington, C.M., Belov, K., Maghzal, G.J., Jarmiin, L.S., Hunt, N.H.) 153/2, 137-144 2009 (学術雑誌) 10.1016/j.cbpb.2009.02.002

Biochemical characteristics and inhibitor selectivity of mouse indoleamine 2,3-dioxygenase-2.
 International Journal of Biochemistry and Cell Biology (Ball, H.J., Yuasa, H.J., Austin, C.J., Weiser, S., Hunt, N.H.) 41/3, 467-471 2009 (学術雑誌) 10.1016/j.biocel.2008.01.005

Evolution of vertebrate indoleamine 2,3-dioxygenases.
 Journal of Molecular Evolution (Yuasa, H.J., Takubo, M., Takahashi, A., Hasegawa, T., Noma, H., Suzuki, T. ) 65/6, 705-714. 2007 (学術雑誌) 10.1007/s00239-007-9049-1

Bacterial expression and characterization of molluscan IDO-like myoglobin.
 Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology (Yuasa, H.J., Hasegawa, T., Nakamura, T. and Suzuki, T. ) 146/4, 461-469 2007 (学術雑誌) 10.1016/j.cbpb.2006.11.028

Do molluscs possess indoleamine 2,3-dioxygenase?
 Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology (Yuasa, H.J., Suzuki, T.) 140/3, 445-454 2005 (学術雑誌) 10.1016/j.cbpc.2004.11.007

Identification of Ca2+-dependent calmodulin-binding proteins in rat spermatogenic cells as complexes of the heat-shock proteins.
 Molecular Reproduction and Development (Moriya, M., Ochiai, M., Yuasa, H.J., Suzuki, N., Yazawa, M.) 69/3, 316-324 2004 (学術雑誌) 10.1002/mrd.20134

Comparison of the sequences of Turbo and Sulculus indoleamine dioxygenase-like myoglobin genes.
 Gene (Suzuki, T., Yokouchi, K., Kawamichi, H., Yamamoto, Y., Uda, K., Yuasa, H.J.) 308/, 89-94 2003 (学術雑誌) 10.1016/S0378-1119(03)00467-0

Genomic structure of the sponge, Halichondria okadai calcyphosine gene.
 Gene (Yuasa, H.J., Nakatomi, A., Suzuki, T., Yazawa, M.) 298/1, 21-27 2002 (学術雑誌) 10.1016/S0378-1119(02)00920-4

The structural organization of ascidian Halocynthia roretzi troponin I genes.
 Journal of Biochemistry (Yuasa, H.J., Kawamura, K., Yamamoto, H. and Takagi, T.) 132/1, 135-141 2002 (学術雑誌) 10.1093/oxfordjournals.jbchem.a003191

Structural organization of lower marine nonvertebrate calmodulin genes.
 Gene (Yuasa, H.J., Suzuki, T., Yazawa, M. ) 279/2, 205-212 2001 (学術雑誌) 10.1016/S0378-1119(01)00755-7

Genomic structure of the sandworm, Perinereis vancaurica tetradentata, troponin C.
 Gene (Yuasa, H.J., Takagi, T.) 268/1-2, 17-22 2001 (学術雑誌) 10.1016/S0378-1119(01)00431-0

The genomic structure of the scallop, Patinopecten yessoensis, troponin C gene: a hypothesis for the evolution of troponin C.
 Gene (Yuasa, H.J., Takagi, T.) 245/2, 275-281 2000 (学術雑誌) 10.1016/S0378-1119(00)00046-9

Genomic structure of the amphioxus calcium vector protein.
 Journal of Biochemistry (Yuasa, h.J., Cox, J.A., Takagi, T.) 126/3, 572-577 1999 (学術雑誌) 10.1093/oxfordjournals.jbchem.a022488

The structural organization of the ascidian, Halocynthia roretzi, calmodulin genes. The vicissitude of introns during the evolution of calmodulin genes.
 Gene (Yuasa, H.J., Yamamoto. H., Takagi, T.) 229/1-2, 163-169 1999 (学術雑誌) 10.1016/S0378-1119(99)00028-1

Diversity of the troponin C genes during chordate evolution.
 Journal of Biochemistry (Yuasa, H.J., Cox, J.A., Takagi, T.) 123/6, 1180-1190 1998 (学術雑誌) 10.1093/oxfordjournals.jbchem.a022059

Cloning and sequencing of three C-type lectins from body surface mucus of the land slug, Incilaria fruhstorferi.
 Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology (Yuasa, H.J., Furuta, E., Nakamura, A., Takagi, T.) 119/3, 479-484 1998 (学術雑誌) 10.1016/S0305-0491(98)00008-X

Primary structure of troponin I isoforms from the ascidian Halocynthia roretzi.
 Journal of Biochemistry (Yuasa, H.J., Sato, S., Yamamoto, H., Takagi, T.) 122/2, 374-380 1997 (学術雑誌) 10.1093/oxfordjournals.jbchem.a021763

Structure of the ascidian, Halocynthia roretzi, troponin C gene.
 Journal of Biochemistry (Yuasa, H.J., Sato, S., Yamamoto, H., Takagi, T.) 121/4, 671-676 1997 (学術雑誌) 10.1093/oxfordjournals.jbchem.a021638

Electrospray ionization mass spectrometric composition of the 400 kDa hemoglobin from the pogonophoran Oligobrachia mashikoi and the primary structures of three major globin chains.
 Biochimica et Biophysica Acta (Yuasa, H.J., Green, B.N., Takagi, T., Suzuki, N., Vinogradov, S.N., Suzuki, T.) 1296/2, 235-244 1996 (学術雑誌) 10.1016/0167-4838(96)00081-7

Convergent evolution. The gene structure of Sulculus 41 kDa myoglobin is homologous with that of human indoleamine dioxygenase.
 Biochimica et Biophysica Acta (Suzuki, T., Yuasa, H., Imai, K.) 1308/1, 41-48 1996 (学術雑誌) 10.1016/0167-4781(96)00059-0

Phylogenetic position of the Japanese river otter Lutra nippon inferred from the nucleotide sequence of 224 bp of the mitochondrial cytochrome b gene.
 Zoological Science (Suzuki, T., Yuasa, H., Machida, Y.) 13/4, 621-626 1996 (学術雑誌) 10.2108/zsj.13.621

The giant extracellular hemoglobin from the polychaete Neanthes diversicolor. The cDNA-derived amino acid sequence of linker chain L2 and the exon/intron boundary conserved in linker genes.
 Biochimica et Biophysica Acta (Suzuki, T., Ohta, T., Yuasa, H.J., Takagi, T.) 1217/3, 291-296 1994 (学術雑誌) 10.1016/0167-4781(94)90288-7

Primary structure of Tetrahymena hemoglobins.
 Biochimica et Biophysica Acta (Takagi, T., Iwaasa, H., Yuasa, H., Shikama, K., Takemasa, T., Watanabe, Y.) 1173/1, 75-78 1993 (学術雑誌) 0.1016/0167-4781(93)90245-9

■ 研究業績(著書)

■ 研究業績(口頭・ポスター)
トリプトファン分解酵素の分子進化の新局面 X A New Aspect of Molecular Evolution of Indoleamine 2,3-dioxygemase. Season 10: IDO and TDO in invertebrate species. (第91回日本生化学会大会 2018 ポスター)

Molecular Evolution of Tryptophan-degrading Enzymes. (The 15th International Society for Tryptophan Research Conference (ISTRY2018) 2018 口頭発表)

トリプトファン分解酵素の分子進化の新局面 IX A New Aspect of Molecular Evolution of Indoleamine 2,3-dioxygemase. Season 9: Four IDO isoforms from the ciliate, Blepharisma stoltei. (第90回日本生化学会大会(2017年度 生命科学系学会合同年次大会) 2017 ポスター)

ツールとしての祖先型配列:キメラ解析への応用 (第19回日本進化学会大会 2017 口頭発表)

トリプトファン分解酵素の分子進化の新局面 VIII A New Aspect of Molecular Evolution of Indoleamine 2,3-dioxygemase. Season 8:Two amino acid substitutions are sufficient to bestow high affinity for L-Trp on IDO2. (第89回日本生化学会大会 2016 ポスター)

トリプトファン分解酵素の分子進化の新局面 VII A New Aspect of Molecular Evolution of Indoleamine 2,3-dioxygemase. Season 7:How to evolve to the higher efficiency IDO. (第88回日本生化学会大会 2015 ポスター)

トリプトファン分解酵素にみる分子進化 (第17回日本進化学会大会 2015 口頭発表)

トリプトファン分解酵素の分子進化の新局面 VI A New Aspect of Molecular Evolution of Indoleamine 2,3-dioxygemase. Season 6:The role of Ser/Thr in the distal heme pocket. (第87回日本生化学会大会 2014 ポスター)

トリプトファン分解酵素の分子進化の新局面 V A New Aspect of Molecular Evolution of Indoleamine 2,3-dioxygemase. Season 5:Invertebrate IDOs. (第86回日本生化学会大会 2013 ポスター)

無脊椎動物トリプトファン分解酵素の分子進化 (第84回日本動物学会大会 2013 口頭発表)

トリプトファン分解酵素の分子進化の新局面 IV A New Aspect of Molecular Evolution of Indoleamine 2,3-dioxygemase. Season 4:IDO with very low catalytic activity are well conserved across kingdoms. (第85回日本生化学会大会 2012 ポスター)

トリプトファン分解酵素の分子進化の新局面 III A New Aspect of Molecular Evolution of Indoleamine 2,3-dioxygemase. Season 3:IDOγ, the 3rd IDO from Ascormycota fungi. (第84回日本生化学会大会 2011 ポスター)

トリプトファン分解酵素の分子進化の新局面 II A New Aspect of Molecular Evolution of Indoleamine 2,3-dioxygemase. Season 2:Fungal and Bacterial IDOs. (第83回日本生化学会大会/第33回日本分子生物学会年会 合同大会 2010 ポスター)

トリプトファン分解酵素の分子進化の新局面 A New Aspect of Molecular Evolution of Indoleamine 2,3-dioxygemase. (第82回日本生化学会大会 2009 ポスター)

A new aspect of molecular evolution of IDO-related proteins. (Sixth Australian Conference on the Kynurenine Pathway of Tryptophan Metabolism 2007 口頭発表)

Bacterial expression and characterization of molluscan IDO-related proteins. (20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress 2006 ポスター)

Bacterial expression and characterization of mammalian IDO and molluscan IDO-related proteins. (第78回日本生化学会大会 2005 ポスター)

■ 研究業績(特許)

■ 研究業績(その他の活動)


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