■ 氏名
西原 利治 (サイバラ トシジ)
SAIBARA Toshiji

■ 所属部局/職名
Research and Education Faculty, Medical Sciences Cluster, Clinical Medicine Unit/Professor
教育研究部 医療学系 臨床医学部門/教授

■ 学部・学科・コース等
Medical School, Medical Course, Department of Gastroenterology and Hepatology
医学部 医学科 消化器内科学

■ 連絡先
住 所
電 話088-880-2338
F A X
E-Mail
U R L

■ 出身大学院・研究科等

■ 出身学校・専攻等

■ 取得学位
医学博士 (論文) 京都大学 消化器内科学

■ 研究職歴
2003-2003 高知医科大学 助教授
2003-2009 高知大学   助教授
2009- 高知大学   教授

■ 委員歴・役員歴

■ 受賞学術賞

■ 所属学会
日本消化器病学会
 (評議員 国内)
日本肝臓学会
 (評議員 国内)

■ 専門分野
医学/内科学/消化器病学,肝臓病学

■ 主な研究テーマ・活動
肝細胞癌,自己免疫性肝疾患,NASH

■ 研究についてのPR
臨床に還元できることを目的に、Disease oriented clinical and basic research を目指しております

■ 社会人・生徒を対象として可能な講演・授業(例えば講演題目)

■ 研究業績(論文・解説)
A novel type hypertrigly ceridemia observed in FLS mice.
 Lipids () /38, 687-92 2003 (学術雑誌)

Pitavastatin ameliorates severe hepatic steatosis in aromatase-deficient(Ar-1-)mice.
 Lipids () /38, 519-523 2003 (学術雑誌)

Fenofibrate, a ligand for PPARα, inhibits aromatase cytochrome P450 expression in the ovary of mouse
 J. Lipid Res () /44, 265-270 2003 (学術雑誌)

Polymorphisms in microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in Japanese patients with nonalcoholic steatohepatitis
 J Hepatol () 40:781-786/, 2004 ()

Aromatase-knockout mouse carrying an estrogen-inducible enhanced green fluorescent protein gene facilitates detection of estrogen actions in vivo.
 Endocrinology () 145:1880-1888/, 2004 ()

Polymorphisms of interleukin 1・ and ・3-adrenergic receptor in Japanese patients with nonalcoholic steatohepatitis.
 Alcohol Clin Exp Res () 28:106S-110S/, 2004 ()

Expression of the estrogen-inducible EGFP gene in aromatase-null mice reveals differential tissue response to estrogenic compounds.
 Mol Cell Endocrinol () 14:119-126/, 2005 ()

CYP17 polymorphism as a risk factor of tamoxifen-induced hepatic steatosis in breast cancer patients
 Oncol Rep () 13:465-489/, 2005 ()

Similar anti-mitochondrial antibody reactivity profiles in familial primary biliary cirrhosis.
 Hepatol Res () 33/, 33-38 (学術雑誌)

Effects of obstructive sleep apnea syndrome on hepatic steatosis and nonalcoholic steatohepatitis.
 Hepatol Res (Tatsumi K, Saibara T.) 33/, 100-104 2005 (学術雑誌)

In vivo imaging of hepatic fatty acid metabolism in patients with nonalcoholic steatohepatitis using semiquantative 123I-BMIPP liver scan.
 Hepatol Res (Fukumoto M, Masuda K, Ogawa Y, Nishioka A, Ohnishi T, Murata Y, Yoshida S, Ono M, Saibara T, Onishi S.) 33/, 105-109 2005 (学術雑誌)

CYP17 polymorphism and tamoxifen-induced hepatic steatosis.
 Hepatol Res (Ohnishi T, Ogawa Y, Saibara T, Nishioka A, Kariya S, Fukumoto M, Onishi S, Yoshida S.) 33/, 178-180 2005 (学術雑誌)

Assessment of anti-estrogenic activity of tamoxifen in transgenic mice expressing an enhanced green fluorescent protein gene regulated by estrogen response element.
 Biochim Biophys Acta (Hayashi Y, Toda K, Saibara T, Okada T, Enzan H.) 1760/, 164-171 2006 (学術雑誌)

Interferon-beta plus ribavirin for patients with hepatitis C virus genotype 1: a randomised pilot trial.
 Gut (Enomoto M, Tamori A, Kawada N, Jomura H, Nishiguchi S, Saibara T, Onishi S, Mochida S, Fujiwara K.) 55/, 139-140 2006 (学術雑誌)

Vascularization in tissue remodeling after rat hepatic necrosis induced by dimethylnitrosamine.
 Med Mol Morphol (Jin YL, Enzan H, Kuroda N, Hayashi Y, Toi M, Miyazaki E, Hamauzu T, Hiroi M, Guo LM, Shen ZS, Saibara T.) 39/, 33-43 2006 (学術雑誌)

In vivo imaging of hepatic fatty acid metabolism in patients with non-alcoholic steatohepatitis using semiquantitative 123I-labeled branched-chain fatty acid analog.
 J Gastroenterol Hepatol (Onishi S, Saibara T.) 21 (Suppl 3)/, S76-S78 2006 (学術雑誌)

The phosphatidylethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population.
 J Hepatol (Dong H, Wang J, Li C, Hirose A, Nozaki Y, Takahashi M, Ono M, Akisawa N, Iwasaki S, Saibara T, Onishi S.) 46/, 915-920 2007 (学術雑誌)

Obstructive sleep apnea syndrome is associated with some components of metabolic syndrome.
 Chest (Kono M, Tatsumi K, Saibara T, Nakamura A, Tanabe N, Takiguchi Y, Kuriyama T.) 131/, 1387-1392 2007 (学術雑誌)

Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis.
 Hepatology (Hirose A, Ono M, Saibara T, Nozaki Y, Masuda K, Yoshioka A, Takahashi M, Akisawa N, Iwasaki S, Oben JA, Onishi S.) 45/, 1375-81 2007 ()

Decreased lipoprotein lipase in obstructive sleep apnea syndrome.
 Circ J (Iesato K, Tatsumi K, Saibara T, Nakamura A, Terada J, Tada Y, Sakao S, Tanabe N, Takiguchi Y, Kuriyama T.) 71/, 1293-1298 2007 (学術雑誌)

Fibrate for treatment of primary biliary cirrhosis.
 Hepatol Res (Iwasaki S, Akisawa N, Saibara T, Onishi S.) 37(Suppl 3)/, S515- S517 2007 (学術雑誌)

Preserved tissue-structure of efferent ductules in aromatase deficient mice.
 J Endocrinol (Toda K, Okada T, Hayashi Y, Saibara T.) 199/, 137-146 2008 (学術雑誌)

Mutations in the small heterodimer partner gene increase morbidity risk in Japanese type 2 diabetes patients.
 Human Mutat (Enya M, Horikawa Y, Kuroda E, Yonemaru K, Tonooka N, Tomura H, Oda N, Yokoi N, Yamagata K, Shihara N, Iizuka K, Saibara T, Seino S, Takeda J) 29/, E271-E277 2008 (学術雑誌)

Expression of fascin-1, an actin-bundling protein, in migrating hepatoblasts during rat liver development.
 Cell Tissue Res (Hayashi Y, Toda K, Saibara T, Okamoto S, Osanai M, Enzan H, Lee GH.) 334/, 219-226 2008 (学術雑誌)

Recurrent familial hypobetalipoproteinemia-induced nonalcoholic fatty liver disease after living donor liver transplantation.
 Liver Transpl. (Harada N, Soejima Y, Taketomi A, Yoshizumi T, Uchiyama H, Ikegami T, Saibara T, Nishizaki T, Maehara Y.) 15/806-809, 2009 (学術雑誌)

Effects of Eriobotrya japonica seed extract on oxidative stress in rats with non-alcoholic steatohepatitis.
 J Pharm Pharmacol (Yoshioka S, Hamada A, Jobu K, Yokota J, Onogawa M, Kyotani S, Miyamura M, Saibara T, Onishi S, Nishioka Y.) 62/, 241-246 2010 (学術雑誌)

Deletion of tumor necrosis factor-alpha receptor type 1 exacerbates insulin resistance and hepatic steatosis in aromatase knockout mice.
 Biochim Biophys Acta. (Toda K, Hayashi Y, Saibara T.) 1801/6, 655-664 2010 (学術雑誌)

Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease.
 Gut (Asanuma T, Ono M, Kubota K, Hirose A, Hayashi Y, Saibara T, Inanami O, Ogawa Y, Enzan H, Onishi S, Kuwabara M, Oben JA.) 50/2, 258-266 2010 (学術雑誌)

Efficacy of bezafibrate for chronic GVHD of the liver after allogeneic hematopoietic stem cell transplantation.
 Bone Marrow Transplant. (Hidaka M, Iwasaki S, Matsui T, Kawakita T, Inoue Y, Sakai T, Harada N, Takemoto S, Nagakura S, Kiyokawa T, Takahashi M, Saibara T, Onishi S, Kawano F.) 45/5, 912-918 2010 ()

Effects of Eriobotrya japonica seed extract on oxidative stress in rats with non-alcoholic steatohepatitis.
 J Pharm Pharmacol (Yoshioka S, Hamada A, Jobu K, Yokota J, Onogawa M, Kyotani S, Miyamura M, Saibara T, Onishi S, Nishioka Y.) 62/, 241-246 2010 (学術雑誌)

Matrix metalloproteinase-1 expression in splenic angiosarcoma metastasizing to the serous membrane.
 Int J Clin Exp Pathol (Takeuchi T, Iwasaki S, Miyazaki J, Nozaki Y, Takahashi M, Ono M, Saibara T, Furihata M.) 3/6, 634-639 2010 (学術雑誌)

A simple clinical scoring system using ferritin, fasting insulin, and type IV collagen 7S for predicting steatohepatitis in nonalcoholic fatty liver disease.
 J Gastroenterol (Sumida Y, Yoneda M, Hyogo H, Yamaguchi K, Ono M, Fujii H, Eguchi Y, Suzuki Y, Imai S, Kanemasa K, Fujita K, Chayama K, Yasui K, Saibara T, Kawada N, Fujimoto K, Kohgo Y, Okanoue T; Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD).) 46/2, 257-68 (学術雑誌)

Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma.
 Clin Gastroenterol Hepatol (Yasui K, Hashimoto E, Komorizono Y, Koike K, Arii S, Imai Y, Shima T, Kanbara Y, Saibara T, Mori T, Kawata S, Uto H, Takami S, Sumida Y, Takamura T, Kawanaka M, Okanoue T; Japan NASH Study Group, Ministry of Health, Labour, and Welfare of Japan.) 9/, 428-33 2011 (学術雑誌)

A novel and comprehensive mouse model of human non-alcoholic steatohepatitis with the full range of dysmetabolic and histological abnormalities induced by gold thioglucose and a high-fat diet.
 Liver Int (Ogasawara M, Hirose A, Ono M, Aritake K, Nozaki Y, Takahashi M, Okamoto N, Sakamoto S, Iwasaki S, Asanuma T, Taniguchi T, Urade Y, Onishi S, Saibara T, Oben JA.) 31/, 542-51 2011 (学術雑誌)

Overexpression of GalNAc-transferase GalNAc-T3 promotes pancreatic cancer cell growth.
 Oncogene (Taniuchi K, Cerny RL, Tanouchi A, Kohno K, Kotani N, Honke K, Saibara T, Hollingsworth MA.) 30/, 4843-54 2011 (学術雑誌)

Platelet count for predicting fibrosis in nonalcoholic fatty liver disease.
 J Gastroenterol (Yoneda M, Fujii H, Sumida Y, Hyogo H, Itoh Y, Ono M, Eguchi Y, Suzuki Y, Aoki N, Kanemasa K, Imajo K, Chayama K, Saibara T, Kawada N, Fujimoto K, Kohgo Y, Yoshikawa T, Okanoue T; Japan Study Group of Nonalcoholic Fatty Liver Disease.) 46/, 1300-6 2011 (学術雑誌)

BART inhibits pancreatic cancer cell invasion by inhibiting ARL2-mediated RhoA inactivation.
 Int J Oncol. (Taniuchi K, Iwasaki S, Saibara T) 39/, 1243-52 2011 (学術雑誌)

Serum dehydroepiandrosterone sulphate levels in patients with non-alcoholic fatty liver disease.
 Intern Med. (Koga M, Saito H, Mukai M, Saibara T, Kasayama S.) 50/, 1657-61 2011 (学術雑誌)

Angiotensinogen gene haplotype is associated with the prevalence of Japanese non-alcoholic steatohepatitis.
 Hepatol Res. (Ono M, Ochi T, Munekage K, Ogasawara M, Hirose A, Nozaki Y, Takahashi M, Okamoto N, Saibara T.) 41/, 1223-9. 2011 (学術雑誌)

Impact of ovarian sex steroids on ovulation and ovulatory gene induction in aromatase-null mice.
 Endocrinology (Toda K, Hayashi Y, Ono M, Saibara T.) 153/, 386-94. 2012 (学術雑誌)

Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population.
 BMC Gastroenterol. (Sumida Y, Yoneda M, Hyogo H, Itoh Y, Ono M, Fujii H, Eguchi Y, Suzuki Y, Aoki N, Kanemasa K, Fujita K, Chayama K, Saibara T, Kawada N, Fujimoto K, Kohgo Y, Yoshikawa T, Okanoue T; Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD).) 12/, 2 2012 (学術雑誌)

Usefulness of Technetium-99 m-2-methoxy-isobutyl-isonitrile liver scintigraphy for evaluating disease activity of non-alcoholic fatty liver disease.
 Hepatol Res. (Masuda K, Ono M, Fukumoto M, Hirose A, Munekage K, Ochi T, Okamoto N, Akagi N, Ogawa Y, Saibara T.) 42/, 273-9 2012 (学術雑誌)

Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study.
 J Gastroenterol. (Eguchi Y, Hyogo H, Ono M, Mizuta T, Ono N, Fujimoto K, Chayama K, Saibara T; JSG-NAFLD.) 47/, 586-95 2012 (学術雑誌)

Is impaired Kupffer cell function really important to the pathogenesis of nonalcoholic steatohepatitis?
 J Gastroenterol Hepatol. (Ono M, Saibara T.) 27/, 622-4 2012 (学術雑誌)

Clinical and pathological progression of non-alcoholic steatohepatitis to hepatocellular carcinoma.
 Hepatol Res. (Yasui K, Hashimoto E, Tokushige K, Koike K, Shima T, Kanbara Y, Saibara T, Uto H, Takami S, Kawanaka M, Komorizono Y, Okanoue T; The Japan NASH Study Group.) 42/, 767-773 2012 (学術雑誌)

BART inhibits pancreatic cancer cell invasion by PKCα inactivation through binding to ANX7.
 PLoS One. (Taniuchi K, Yokotani K, Saibara T.) 7/, e35674 2012 (学術雑誌)

17β-Estradiol is critical for the preovulatory induction of prostaglandin E(2) synthesis in mice.
 Mol Cell Endocrinol. (Toda K, Ono M, Yuhki K, Ushikubi F, Saibara T.) 362/, 176-82. 2012 (学術雑誌)

Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese.
 PLoS One. (Kawaguchi T, Sumida Y, Umemura A, Matsuo K, Takahashi M, Takamura T, Yasui K, Saibara T, Hashimoto E, Kawanaka M, Watanabe S, Kawata S, Imai Y, Kokubo M, Shima T, Park H, Tanaka H, Tajima K, Yamada R, Matsuda F; Takeshi Okanoue, Japan Study Group of Nonalcoholic Fatty Liver Disease.) 7/, e38322. 2012 (学術雑誌)

BART inhibits pancreatic cancer cell invasion by Rac1 inactivation through direct binding to active Rac1.
 Neoplasia. (Taniuchi K, Yokotani K, Saibara T.) 14/, 440-50. 2012 (学術雑誌)

Abnormality in expression levels of gluconeogenesis-related genes by high-dose supplementation with pyridoxamine in mice.
 Int J Vitam Nutr Res (Thi Viet Do H, Toda K, Saibara T, Yagi T.) 82/, 34-40 2012 (学術雑誌)

Noninvasive scoring systems in patients with nonalcoholic fatty liver disease with normal alanine aminotransferase levels.
 J Gastroenterol. (Yoneda M, Imajo K, Eguchi Y, Fujii H, Sumida Y, Hyogo H, Ono M, Suzuki Y, Kawaguchi T, Aoki N, Sata M, Kanemasa K, Kohgo Y, Saibara T, Chayama K, Itoh Y, Yoshikawa T, Anzai K, Fujimoto K, Okanoue T, Nakajima A; Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD).) /, 2012 (学術雑誌)

Liver acid sphingomyelinase inhibits growth of metastatic colon cancer.
 J Clin Invest (Osawa Y, Suetsugu A, Matsushima-Nishiwaki R, Yasuda I, Saibara T, Moriwaki H, Seishima M, Kozawa O.) /, 2012 (学術雑誌) pii: 65188. 10.1172/JCI65188.

The pharmacokinetics and pharmacodynamics of tolvaptan in patients with liver cirrhosis with insufficient response to conventional diuretics: a multicentre, double-blind, parallel-group, phase III study.
  () /, (学術雑誌)

Hepatocyte destruction with enhanced collagen synthesis: characteristic feature of chronic hepatitis C patients on haemodialysis.
  () /, ()

Clinical efficacy of combination therapy with ME3738 and pegylated interferon-alpha-2a in patients with hepatitis C virus genotype 1.
  () /, ()

Tumor necrosis factor-α promotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells.
  () /, ()

Bofutsushosan, a Japanese herbal (Kampo) medicine, attenuates progression of nonalcoholic steatohepatitis in mice.
  () /, ()

The association of insomnia with gastroesophageal reflux symptoms in biopsy-proven nonalcoholic fatty liver disease.
  () /, ()

Evaluation of Ki-67 index in EUS-FNA specimens for the assessment of malignancy risk in pancreatic neuroendocrine tumors.
  () /, ()

Glycemic variability is an independent predictive factor for development of hepatic fibrosis in nonalcoholic fatty liver disease.
  () /, ()

Aromatase-null mice expressing enhanced green fluorescent protein in germ cells provide a model system to assess estrogen-dependent ovulatory responses.
  () /, ()

Type 2 diabetes mellitus is associated with the fibrosis severity in patients with nonalcoholic fatty liver disease in a large retrospective cohort of Japanese patients.
  () /, ()

Upper limit of normal serum alanine aminotransferase levels in Japanese subjects.
  () /, ()

Multicenter validation study of anti-programmed cell death-1 antibody as a serological marker for type 1 autoimmune hepatitis.
  () /, ()

RUVBL1 directly binds actin filaments and induces formation of cell protrusions to promote pancreatic cancer cell invasion.
  () /, ()

Safety and efficacy of image-guided enzyme-targeting radiosensitization and intraoperative radiotherapy for locally advanced unresectable pancreatic cancer.
  () /, ()

Simultaneous occurrence of gastric lipoma and early gastric cancer.
  () /, ()

Simple scoring system for predicting cirrhosis in nonalcoholic fatty liver disease.
  () /, ()

■ 研究業績(著書)
NASH診療ハンドブック(2007)
 出版社:中外医学社
 ISBN:978-4-498-04292-6

NASH診療best approach(2008)
 出版社:中外医学社
 ISBN:978-4-498-14202-2

■ 研究業績(口頭・ポスター)

■ 研究業績(特許)
Provisional US patent application (Method for detecting a risk of lipid metabolism deficiency, and a test agent used thereafter.)

■ 研究業績(その他の活動)


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