■ 氏名
大畑 雅典 (ダイバタ マサノリ)
DAIBATA Masanori

■ 所属部局/職名
Research and Education Faculty, Medical Sciences Cluster, Basic Medicine Unit/Professor
教育研究部 医療学系 基礎医学部門/教授

■ 学部・学科・コース等
Medical School, Medical Course, Department of Microbiology and Infection
医学部 医学科 微生物学

■ 連絡先
住 所高知県南国市岡豊町小蓮
電 話088-880-2321
F A X088-880-2324
E-Maildaibatam●kochi-u.ac.jp    (送信の際は“●”を半角の“@”に変更して送信してください。)
U R Lhttp://www.kochi-ms.ac.jp/~ff_mcrbi/index.html

■ 出身大学院・研究科等
高知大学 博士(医学研究科 ) 1989 (修了)

■ 出身学校・専攻等
高知大学 (医学部 ) 1985 (卒業)

■ 取得学位
医学博士 (課程) 血液内科学

■ 研究職歴
1989年     高知医科大学大学院博士課程修了
1989年〜1994年 米国マサチューセッツ医科大学 Instructor
1994年〜2000年 高知医科大学 第三内科 助手
2000年〜2007年 高知大学 医学部 血液・呼吸器内科 講師
2007年〜2009年 高知大学 医学部 血液・呼吸器内科 准教授
2009年〜 高知大学 医学部 教授

■ 委員歴・役員歴

■ 受賞学術賞
日本癌学会奨励賞 (2000年)
高知信用金庫・安心友の会 学術賞 (1999年)

■ 所属学会
日本内科学会
 (総合内科専門医・指導医 国内)
日本血液学会
 (専門医・代議員・指導医 国内)
日本感染症学会
 (専門医・指導医・評議員 国内)
日本呼吸器学会
 (専門医・指導医 国内)
日本化学療法学会
 (抗菌化学療法専門医・指導医 国内)
日本ウイルス学会
 (評議員 国内)
日本がん治療認定医機構
 (がん治療認定医・指導医 国内)
ICD制度協議会
 (インフェクションコントロールドクター 国内)
日本癌学会
 ( 国内)
日本リンパ網内系学会
 ( 国内)
日本細菌学会
 ( 国内)
米国血液学会(ASH)
 ( 国外)
米国癌学会(AACR)
 ( 国外)

■ 専門分野
ウイルス学・臨床感染症学・血液学・腫瘍学・呼吸器病学

■ 主な研究テーマ・活動
【研究テーマ】
「ウイルスと発がんについて」
ヒトのがん全体の約25%はウイルスや細菌などの微生物が原因であることが明らかになっている。特に「ウイルスによる発がん」はがん研究の中でも大きな研究領域を占めている。
HTLV-Iによる成人T細胞白血病(ATL)、C型肝炎ウイルス(HCV)による肝がん、ヒトパピローマウイルス(HPV)による子宮頸がん、またヘルペスウイルスに属するEpstein-Barrウイルス(EBV)による種々の悪性リンパ腫、ホジキンリンパ腫、胃がんなどはその代表である。さらに2008年にはヒトに癌を惹起する第7番目の腫瘍ウイルスとしてメルケル細胞ポリオーマウイルス(MCPyV)が報告された。
当分野では、これらウイルスによる発がんメカニズム解明に向けての研究をおこなう。
またヒトヘルペスウイルス6(HHV-6)とその感染様式および造血器腫瘍との関連性についても探索する。


■ 研究についてのPR
【受賞歴】
1999年:高知信用金庫・高知安心友の会 学術賞
2000年:日本癌学会 奨励賞 研究課題「リンパ指向性ウイルスと造血器腫瘍」

■ 社会人・生徒を対象として可能な講演・授業(例えば講演題目)
感染症学・ウイルス学・血液学・腫瘍学

■ 研究業績(論文・解説)
Generation and characteristics of a novel "double-hit" high grade B-cell lymphoma cell line DH-My6 with MYC/IGH and BCL6/IGH gene arrangements and potential molecular targeted therapies.
 Oncotarget (H. Kikuchi, T. Higuchi, Y. Hashida, A. Taniguchi, M. Kamioka, T. Taguchi, A. Yokoyama, I. Murakami, M. Fujieda, M. Daibata.) 9/, 33482-33499 2018 (学術雑誌)

Genetic Variability of the Noncoding Control Region of Cutaneous Merkel Cell Polyomavirus: Identification of Geographically-Related Genotypes.
 The Journal of Infectious Diseases (Y. Hashida, T. Higuchi, K. Matsui, Y. Shibata, K. Nakajima, S. Sano, M. Daibata.) 217/, 1601-1611 2018 (学術雑誌)

Prevalence and genetic variability of human polyomaviruses 6 and 7 in healthy skin among asymptomatic individuals.
 The Journal of Infectious Diseases. (Y. Hashida, T. Higuchi, S. Matsuzaki, K. Nakajima, S. Sano, M. Daibata. ) 217/, 483-493 2018 (学術雑誌)

Merkel cell polyomavirus and Langerhans cell neoplasm.
 Cell Communication and Signaling. (I. Murakami, N. Wada, J. Nakashima, M. Iguchi, M. Toi, Y. Hashida, T. Higuchi, M. Daibata, M. Matsushita, T. Iwasaki, S. Kuwamoto, Y. Horie, K. Nagata, K. Hayashi, T. Oka, T. Yoshino, T. Imamura, A. Morimoto, S. Imashuku, J. Gogusev, F. Jaubert.) 16/, 49 2018 (学術雑誌)

Recovery of micobacteriophages from archival stocks stored for approximately 50 years in Japan.
 Archives of Virology. (T. Ujihara, J. Uchiyama, T. Nasukawa, H. Ando, H. Murakami, N. Ohara, H. Taniguchi, T. Yamazaki, M. Daibata, M. Sakaguchi, S. Matsuzaki.) /, 2018 (学術雑誌)

Isolation of Bacteriophages for Fastidious Bacteria.
 Methods in Molecular Biology. (S. Matsuzaki, J. Uchiyama, I. Takemura-Uchiyama, T. Ujihara, M. Daibata.) 1693/, 3-10 2018 (学術雑誌)

Differential gene expression profiling linked to tumor progression of splenic marginal zone lymphoma.
 Scientific Reports. (T. Higuchi, Y. Hashida, A. Taniguchi, M. Kamioka, M. Daibata. ) 7/, 11026 2017 (学術雑誌)

Monitoring of Epstein-Barr virus load and killer T cells in patients with juvenile idiopathic arthritis treated with methotrexate or tocilizumab.
 Modern Rheumatology. (M. Fujieda, K. Tsuruga, T. Sato, H. Kikuchi, W. Tamaki, M. Ishihara, M. Yamamoto, T. Oishi, H. Tanaka, M. Daibata.) 27/, 66-71 2017 (学術雑誌)

Establishment and characterization of a novel Hodgkin lymphoma cell line, AM-HLH, carrying the Epstein-Barr virus genome integrated into the host chromosome.
 Hematological Oncology. (M. Hayashida, M. Daibata, E. Tagami, T. Taguchi, F. Maekawa, K. Takeoka, K. Fukutsuka, D. Shimomura, T. Hayashi, Y. Iwatani, H. Ohno. ) 35/, 567-575 2017 (学術雑誌)

Ecology of Merkel Cell Polyomavirus in Healthy Skin among an Asian Cohort. Journal of Infectious Diseases.
 The Journal of Infectious Diseases. (Y. Hashida, M. Kamioka, M. Tanaka, S. Hosokawa, M. Murakami, K. Nakajima, H. Kikuchi, M. Fujieda, S. Sano, M. Daibata. ) 213/, 1708-1716 2016 (学術雑誌)

High load of Merkel cell polyomavirus DNA detected in the normal skin of Japanese patients with Merkel cell carcinoma.
 Journal of Clinical Virology. (Y. Hashida, K. Nakajima, H. Nakajima, T. Shiga, M. Tanaka, M. Murakami, S. Matsuzaki, S. Naganuma, N. Kuroda, Y. Seki, H. Katano, S. Sano, M. Daibata.) 82/, 101-107 2016 (学術雑誌)

Screening of KHP30-like prophages among Japanese Helicobacter pylori strains, and genetic analysis of a defective KHP30-like prophage sequence integrated in the genome of the H. pylori strain NY40.
 FEMS Microbiology Letters. (J. Uchiyama, I. Takemura-Uchiyama, S. Kato, H. Takeuchi, Y. Sakaguchi, T. Ujihara, M. Daibata, H. Shimakura, N. Okamoto, M. Sakaguchi, S. Matsuzaki. ) /, 2016 (学術雑誌)

Characterization of Pseudomonas aeruginosa phage KPP21 belonging to family Podoviridae genus N4-like viruses isolated in Japan.
 Microbiology and Immunology. (R. Shigehisa, J. Uchiyama, S. Kato, I. Takemura-Uchiyama, K. Yamaguchi, R. Miyata, T. Ujihara, Y. Sakaguchi, N. Okamoto, H. Shimakura, M. Daibata, M. Sakaguchi, S. Matsuzaki. ) 60/, 64-67 2016 (学術雑誌)

Concurrent Merkel cell carcinoma and squamous cell carcinoma in a chest nodule.
 European Journal of Dermatology. (M. Takahashi, H. Fukuda, Y. Yokouchi, Y. Hashida, M. Daibata, H. Mukai.) 25/, 492-494 2015 (学術雑誌)

Epstein-Barr virus-positive pyothorax-associated lymphoma arising from a posttraumatic empyema.
 Acta Haematologica. (A. Taniguchi, Y. Hashida, Y. Nemoto, H. Machida, S. Chi, T. Ikezoe, A. Yokoyama, M. Daibata. ) 134/, 155-160 2015 (学術雑誌)

Prevalence of human cytomegalovirus, polyomaviruses, and oncogenic viruses in glioblastoma among Japanese subjects.
 Infectious agents and cancer. (Y. Hashida, A. Taniguchi, T. Yawata, S. Hosokawa, M. Murakami, M. Hiroi, T. Ueba, M. Daibata.) 10/, 3 (9 pages) 2015 (学術雑誌)

PCR array analysis of gene expression profiles in chronic active Epstein-Barr virus infection.
 Microbes and Infection. (M. Murakami, Y. Hashida, M. Imajoh, A. Maeda, M. Kamioka, Y. Senda, T. Sato, M. Fujieda, H. Wakiguchi, M. Daibata.) 16/, 581-586 2014 (学術雑誌)

Considerations on the link between Merkel cell polyomavirus and lung cancer.
 Lung Cancer Management. (Y. Hashida, M. Daibata.) 3/, 297-299 2014 (学術雑誌)

Phylogenetic analysis of Merkel cell polyomavirus based on full-length LT and VP1 gene sequences derived from neoplastic tumors in Japanese patients.
 Journal of General Virology (Y. Hashida, M. Imajoh, M. Kamioka, A. Taniguchi, N. Kuroda, K. Hayashi, H. Nakajima, S. Sano, M. Daibata.) 95/, 135-141 2014 (学術雑誌)

The age of the phage.
 Nature. (S. Matsuzaki, J. Uchiyama, I. Uchiyama, M. Daibata.) 509/, 7489: S9 2014 (学術雑誌)

Genome analysis of Pseudomonas aeruginosa bacteriophage KPP23, belonging to the family Siphoviridae.
 Genome Announcement. (K. Yamaguchi, R. Miyata, R. Shigehisa, J. Uchiyama, I. Uchiyama, S. Kato, T. Ujihara, Y. Sakaguchi, M. Daibata, S. Matsuzaki. ) 2/, e00233-14 2014 (学術雑誌)

Characterization of a novel Pseudomonas aeruginosa bacteriophage, KPP25, of the family Podoviridae.
 Virus Res. (R. Miyata, K.Yamaguchi, J. Uchiyama, R. Shigehisa, I. Uchiyama, S. Kato, T. Ujihara, Y. Sakaguchi, M. Daibata, S. Matsuzaki. ) 189/, 43-46 2014 (学術雑誌)

Experimental phage therapy against lethal lung-derived septicemia caused by Staphylococcus aureus in mice.
 Microbes and Infection. (I. Uchiyama, J. Uchiyama, M. Osanai, N. Morimoto, T. Asagiri, T. Ujihara, M. Daibata, T. Sugiura, S. Matsuzaki.) 16/, 512-517 2014 (学術雑誌)

In silico analysis of AHJD-like viruses, Staphylococcus aureus phages S24-1 and S13
 Microbiologyopen. (J. Uchiyama, I. Uchiyama, S. Kato, M. Sato, T. Ujihara, H. Matsui, H. Hanaki, M. Daibata, S. Matsuzaki.) 3/, 257-270 2014 (学術雑誌)

Genomic and phylogenetic traits of Staphylococcus phages S25-3 and S25-4 (family Myoviridae, genus Twort-like viruses).
 Annals of Microbiology. (I. Takemura-Uchiyama, J. Uchiyama, S. Kato, T. Ujihara, M. Daibata, S. Matsuzaki.) 64/, 1453-1456 2014 (学術雑誌)

Intragenus generalized transduction in Staphylococcus spp. by a novel giant phage.
 ISME Journal (J. Uchiyama, I. Uchiyama , Y. Sakaguchi, K. Gamoh, S. Kato, M. Daibata, T. Ujihara, N. Misawa, S. Matsuzaki.) 8/, 1949-1952 2014 (学術雑誌)

Pyothorax-associated lymphoma (PAL) with biclonal Epstein-Barr virus infection: characterization of a novel PAL cell line with unique features.
 Leukemia Research (A. Taniguchi, Y. Hashida, Y. Nemoto, T. Taguchi, Y. Iwahara, M. Daibata. ) 37/, 1545-1550 2013 (学術雑誌)

Gene expression analysis in Merkel cell polyomavirus-positive non-small cell lung cancer from Japanese patients.
 International Journal of Cancer. (Y. Hashida, M. Imajoh, M. Daibata. ) 133/, 3014-3015 2013 (学術雑誌)

Detection of Merkel cell polyomavirus with a tumour-specific signature in non-small cell lung cancer.
 British Journal of Cancer. (Y. Hashida, M. Imajoh, Y. Nemoto, M. Kamioka, A. Taniguchi, T. Taguchi, M. Kume, K. Orihashi, M. Daibata. ) 108/, 629-637 2013 (学術雑誌)

Integrated and mutated forms of Merkel cell polyomavirus in non-small cell lung cancer.
 British Journal of Cancer. (Y. Hashida, M. Imajoh, M. Daibata.) 108/, 2624 2013 (学術雑誌)

Absence of Merkel cell polyomavirus in monocytic leukemias.
 Acta Haematologica. (Y. Hashida, M. Imajoh, A. Taniguchi, M. Kamioka, M. Daibata. ) 130/, 135-137 2013 (学術雑誌)

Prevalence and viral DNA loads of three novel human polyomaviruses in skin cancers from Japanese patients.
 The Journal of Dermatology. (M. Imajoh, Y. Hashida, H. Nakajima, S. Sano, M. Daibata. ) 40/, 657-660 2013 (学術雑誌)

Characterization of Helicobacter pylori bacteriophage KHP30.
 Applied and Environmental Microbiology. (J. Uchiyama, H. Takeuchi, S. Kato, K. Gamoh, I. Takemura-Uchiyama, T. Ujihara, M. Daibata, S. Matsuzaki. ) 79/, 3176-3184 2013 (学術雑誌)

Genotypic characteristics of a Mycobacterium sp. isolated from yellowtail Seriola quinqueradiata and striped jack Pseudocaranx dentex in Japan.
 Microbiology and Immunology. (I. Masayuki, H. Sugiura, Y. Hashida, K. Hatai, S. Oshima, M. Daibata, K. Kawai.) 57/, 13-20 2013 (学術雑誌)

Evaluating efficacy of bacteriophage therapy against Staphylococcus aureus infections using a silkworm larval infection model.
 I. Uchiyama, J. Uchiyama, S, Kato, T. Inoue, T. Ujihara, N. Ohara, M. Daibata, S. Matsuzaki. (FEMS Microbiology Letters.) 347/, 52-60 2013 (学術雑誌)

Synergistic bacteriolysis by bacteriophage EF24C endolysin ORF9 and lantibiotic nisin and its application to pulsed-field gel electrophoreic analysis of Enterococcus faecalis.
 Annals of Microbiology. (I. Takemura-Uchiyama, J. Uchiyama, M. Satoh, T. Uhihara, M. Daibata, S. Matsuzaki. ) 63/, 1209-1211 2013 (学術雑誌)

Detection of Merkel cell polyomavirus in cervical squamous cell carcinomas and adenocarcinomas from Japanese patients.
 Virology Journal. (M. Imajoh, Y. Hashida, Y. Nemoto, H. Oguri, N. Maeda, M. Furihata, T. Fukaya, M. Daibata. ) 9/, 154 2012 (学術雑誌)

High-throughput sequencing analysis of the chromosome 7q32 deletion reveals IRF5 as a potential tumour suppressor in splenic marginal-zone lymphoma.
 British Journal of Haematology. (V. Fresquet, E.F. Robles, A. Parker, J. Martinez-Useros, M. Mena, R. Malumbres, X. Agirre, S. Catarino, D. Arteta, L. Osaba, M. Mollejo, J. M. Hernandez-Rivas, M. J. Calasanz, M. Daibata, M. J. Dyer, F. Prosper, E. Vizcarra, M. Piris, D. Oscier, J. A. Martinez-Climent.) 158/, 712-726 2012 (学術雑誌)

Novel human polyomaviruses, Merkel cell polyomavirus and human polyomavirus 9, in Japanese chronic lymphocytic leukemia cases.
 Journal of Hematology & Oncology. (M. Imajoh, Y. Hashida, A. Taniguchi, M. Kamioka, M. Daibata. ) 5/, 25 2012 (学術雑誌)

Characterization of Epstein-Barr virus (EBV) BZLF1 gene promoter variants and comparison of cellular gene expression profiles in Japanese patients with infectious mononucleosis, chronic active EBV infection, and EBV-associated hemophagocytic lymphohistiocytosis.
 Journal of Medical Virology. (M. Imajoh, Y. Hashida, M. Murakami, A. Maeda, T. Sato, M. Fujieda, H. Wakiguchi, M. Daibata. ) 84/, 940-946 2012 (学術雑誌)

Involvement of KRAS G12A mutation in the IL-2-independent growth of a human T-LGL leukemia cell line, PLT-2.
 Nagoya Journal of Medical Science. (N. Mizutani, H. Ito, K. Hagiwara, M. Kobayashi, A. Hoshikawa, Y. Nishida, A. Takagi, T. Kojima, M. Suzuki, Y. Osawa, K. Ohishi, M. Daibata, T. Murate. ) 74/, 261-271 2012 (大学・研究所等紀要)

Pseudomonas aeruginosa keratitis in mice: effects of topical bacteriophage KPP12 administration.
 PlosOne. (K. Fukuda, W. Ishida, J. Uchiyama, M. Rashel, S. Kato, T. Morita, A. Muraoka, T. Sumi, S. Matsuzaki, M. Daibata, A. Fukushima.) 7/, e47742 2012 (学術雑誌)

Complete genome sequences of two Helicobacter pylori bacteriophages isolated from Japanese patients.
 Journal of Virology (J. Uchiyama, H. Takeuchi, S. Kato, I. Takemura-Uchiyama, T. Ujihara, M. Daibata, S. Matsuzaki. ) 86/, 11400-11401 2012 (学術雑誌)

Analysis of deoxynucleosides in bacteriophages φEF24C and K and the frequency of a specific restriction site in the genomes of bacteriophage subfamily Spounavirinae.
 Archives of Virology (J. Uchiyama, Y. Maeda, I. Takemura, K. Gamoh, S. Matsuzaki, M. Daibata. ) 157/, 1587-1592 2012 (学術雑誌)

Genetic characterization of Pseudomonas aeruginosa bacteriophage KPP10.
 Archives of Virology (J. Uchiyama, R. Mohammad, I. Takemura, S. Kato, T. Ujihara, A.Muraoka, S. Matsuzaki, M. Daibata. ) 154/, 733-738 2012 (学術雑誌)

Promoter methylation of the bone morphogenetic protein 6 gene in multiple myeloma.
 Oncology Reports (Y. Hashida, Y. Nemoto, M. Imajoh, M. Murakami, A. Taniguchi, N. Komatsu, A. Yokoyama, M. Daibata. ) 27/, 825-830 2012 (学術雑誌)

Multiple sites of highly amplified DNA sequences detected by molecular cytogenetic analysis in HS-RMS-2, a new pleomorphic rhabdomyosarcoma cell line.
 American Journal of Cancer Research (E. Takaoka, H. Sonobe, K Akimaru, S. Sakamoto, T. Shuin, M. Daibata, T. Taguchi, A. Tominaga.) 2/, 141-152 2011 (学術雑誌)

Improved adsorption of an Enterococcus faecalis bacteriophage EF24C with a point mutation.
 PLos ONE (J. Uchiyama, I. Takemura, M. Satoh, S. Kato, T. Ujihara, K. Akechi, S. Matsuzaki, M. Daibata. ) 6/, e26648 2011 (学術雑誌)

Characterization of lytic enzyme ORF9 derived from Enterococcus faecalis bacteriophage 61542;EF24C.
 Applied and Environmental Microbiology. (J. Uchiyama, I. Takemura, I. Hayashi, S. Matsuzaki, M. Sato, T. Ujihara, M. Murakami, M. Imajoh, M. Sugai, M. Daibata. ) 77/, 580-585 2011 (学術雑誌)

Presence of Merkel cell polyomavirus in Japanese cutaneous squamous cell carcinoma
 Journal of Clinical Virology (M. Murakami, M. Imajoh, T. Ikawa, H. Nakajima, M. Kamioka, Y.Nemoto, T. Ujihara, J. Uchiyama, S. Matsuzaki, S. Sano, M. Daibata.) 50/, 37-41 2011 (学術雑誌)

Epstein-Barr virus-infected subcutaneous panniculitis-like T-cell lymphoma associated with methotrexate treatment.
 International Journal of Hematology (Y. Nemoto, A. Taniguchi, M. Kamioka, Y. Nakaoka, M. Hiroi, A. Yokoyama, H. Enzan, M. Daibata) 92/, 364-368 2010 (学術雑誌)

Isolation and characterization of a novel Staphylococcus aureus Bacteriophage φMR25 and its therapeutic potential.
 Archives of Virology. (H.Hoshiba, J. Uchiyama, S. Kato, T. Ujihara, A. Muraoka, M. Daibata, H. Wakiguchi, S. Matsuzaki.) 155/, 545-552 2010 (学術雑誌)

Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma.
 Proc Nat Acad Sci USA. (S. Mathas, S. Kreher, K. J. Meaburn, K. Johrens, B. Lamprecht, C. Assaf, W. Sterry, M. E. Kadin, M. Daibata, S. Joos, M. Hummel, H. Stein, M. Janz, I. Anagnostopoulos, E. Schrock, T. Misteli, B. Dorken.) 106/, 5831-5836 2009 (学術雑誌)

Testican 3 expression in adult T-cell leukemia.
 Leukemia Res. (M. Kamioka, J. Imamura, N. Komatsu, M. Daibata, T. Sugiura.) 33/, 913-918 2009 (学術雑誌)

Erythropoietin-producing Lung Cancer.
 Intern Med. (I. Miyoshi, Y. Uemura, T. Nakai, M. Daibata, M. Ly, P. Saintigny.) 48/, 389-390 2009 (学術雑誌)

Promoter methylation of the bone morphogenetic protein-6 gene in association with adult T-cell leukemia.
 Int J Cancer. (A. Taniguchi, Y. Nemoto, A. Yokoyama, N. Kotani, S. Imai, T. Shuin, M. Daibata.) 123/, 1824-1831 2008 (学術雑誌)

Ultrastructural study of the morphogenesis of human herpesvirus 6 type B in human T-lymphotropic virus type I-producing lymphoid cells.
 Med. Mol. Morphol. (Y. Ohtsuki, M. Daibata, K. Bandobashi, G.H. Lee, M. Furihata, A. Yokoyama, I. Miyoshi.) 41/, 204-210 2008 (学術雑誌)

Noxa mediates bortezomib induced apoptosis in both sensitive and intrinsically resistant mantle cell lymphoma cells and this effect is independent of constitutive activity of the AKT and NF-kappaB pathways.
 Leukemia and Lymphoma. (EG. Rizzatti, H. Mora-Jensen, MA. Weniger, F. Gibellini, E. Lee, M. Daibata; R. Lai, A. Wiestner.) 49/, 798-808 2008 (学術雑誌)

Cell origin of pyothorax-associated lymphoma: a lymphoma strongly associated with Epstein-Barr virus infection.
 Leukemia. (T. Takakuwa, K. Tresnasari, N Rahadiani, H. Miwa, M. Daibata, K. Aozasa.) 22/, 620-627 2008 (学術雑誌)

Chromosomal integration of human herpesvirus 6 DNA in anticonvulsant hypersensitivity syndrome.
 Bri J Dermatol. (H. Watanabe, M. Daibata, M. Tohyama, J. Batchelor, K. Hashimoto, M. Ijima.) 158/, 640-642 2008 (学術雑誌)

An asian variant of intravascular lymphoma: unique clinical and pathological manifestation in the gallbladder.
 APMIS. (N. Kuroda, M. Mizobuchi, Y. Shimamura, Y. Taniguchi, M. Daibata, I. Miyoshi, T. Ichimura, H. Beppu, M. Ohara, T. Hirouchi, K, Mizuno, G.H. Lee.) 115/, 371-375 2007 (学術雑誌)

Promoter hypermethylation of the bone morphogenetic protein-6 gene in malignant lymphoma.
 Clinical Cancer Res. (M. Daibata, Y. Nemoto, K. Bandobashi, N. Kotani, M. Kuroda, M. Tsuchiya, H. Okuda, T. Takakuwa, S. Imai, T. Shuin, H. Taguchi.) 13/, 3528-3535 2007 (学術雑誌)

A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia.
 Blood. (T. L. Gu, T. Mercher, J. W. Tyner, V. L. Goss, D. K. Walters, M. G. Cornejo, C. Reeves, L. Popova, K. Lee, M. C. Heinrich, J. Rush, M. Daibata, I. Miyoshi, D. G. Gilliland, B. J. Druker, R. D. Polakiewicz.) 110/, 323-333 2007 (学術雑誌)

Psammoma bodies in malignant pleural mesothelioma.
 Intern Med. (I. Miyoshi, N. Komatsu, M. Daibata, M. Kobayashi, M. Hiroi, Y. Ohstuki, H. Taguchi.) 46/, 529-530 2007 (学術雑誌)

Bilateral endobronchial involvement in mantle cell lymphoma.
 Intern Med. (I. Miyoshi, K. Togitani, Y. Kuwayama, M. Daibata, M. Matsumoto, H. Taguchi.) 46/, 429-430 2007 (学術雑誌)

Cutaneous involvement in Hodgkin’s disease.
 Intern Med. (I. Miyoshi, M. Daibata, M. Fujishita, H. Taguchi.) 46/, 73-74 2007 (学術雑誌)

Bridging necrosis and reticulin bridging fibrosis induced by the intrahepatic infiltration of acute biphenotypic leukemia.
 APMIS. (N. Kuroda, M. Mizobuchi, Y. Shimamura, M. Daibata, I. Miyoshi, M. Ohara, T. Hirouchi, K. Mizuno, G.H. Lee.) 114/, 908-911 2006 (学術雑誌)

In vitro Epstein-Barr virus immortalized lymphoma cell line carrying t(9;14)(p13;q32) chromosome abnormality, derived from splenic lymphoma with villous lymphocytes.
 Int J Cancer. (M. Daibata, T. Taguchi, Y. Nemoto, S. Iwasaki, Y. Ohtsuki, H. Taguchi.) 118/, 513-517 2006 (学術雑誌)

Loss of expression of Epstein-Barr virus nuclear antigen-2 correlates with a poor prognosis in cases of pyothorax-associated lymphoma.
 Int J Cancer. (T. Takakuwa, M.F. Ham, W.J. Luo, S. Nakatsuka, M. Daibata, K. Aozasa.) 118/, 2782-2789 2006 (学術雑誌)

Cutaneous and nodal cryptococcosis in an ATL Patient.
 Intern Med. (I. Miyoshi I, N. Hatakeyama, M. Daibata, H. Taguchi.) 45/, 1105-1106 2006 (学術雑誌)

Disseminated mucormycosis (zygomycosis) in acute myeloid leukemia.
 Intern Med. (T. Saito, T. Ikezoe, M. Daibata, T. Takeuchi, Y. Ohtsuki, H. Taguchi, I. Miyoshi.) 45/, 1073-1074 2006 (学術雑誌)

Nasal T-cell lymphoma.
 Intern Med. (I. Miyoshi, M. Daibata, T. Saito, T. Mitsuoka, N. Kuroda, Y. Ohtsuki, H. Taguchi.) 45/, 569-570 2006 (学術雑誌)

Bence Jones myeloma cells with crystalline inclusions.
 Intern Med. (I. Miyoshi, M. Daibata, T. Saito, Y. Ohtsuki, Taguchi H.) 45/, 337-338 2006 (学術雑誌)

Different breakage-prone regions on chromosome 1 detected in t(11;14)-positive mantle cell lymphoma cell lines and multiple myeloma cell lines are associated with different tumor progression-related mechanisms.
 Cytogenet Genome Res. (C. Rudolph, T. Liehr, D. Steinemann, M. Emura, M. Daibata, Y. Matsuo, N. Emi, M. Abe, R. Lai, K. Mrasek, U. Claussen, B. Schlegelberger.) 112/, 213-221 2006 (学術雑誌)

Absence of Chlamydia psittaci in ocular adnexal lymphoma from Japanese patients.
 Br J Haematol. (M. Daibata, Y. Nemoto, K. Togitani, A.Fukushima, H. Ueno, K. Ouchi , H. Fukushi, S. Imai, H.Taguchi H.) 132/, 651-652 2006 (学術雑誌)

Induction of lytic Epstein-Barr virus (EBV) infection by synergistic action of rituximab and dexamethasone renders EBV-positive lymphoma cells more susceptible to ganciclovir cytotoxicity in vitro and in vivo.
 J Virol. (M. Daibata, K. Bandobashi, M. Kuroda, S. Imai, I. Miyoshi, H. Taguchi.) 79/, 5875-5879 2005 (学術雑誌)

Pulmonary alveolar proteinosis complicating acute myeloid leukemia.
 Br J Haematol. (I. Miyoshi, M. Daibata, S. Takemoto, H. Machida, H. Taguchi.) 131/, 1 2005 (学術雑誌)

Calcaneus involvement by multiple myeloma.
 Am J Hematol. (M. Daibata, K. Bandobashi, H. Taguchi.) 80/, 311-312 2005 (学術雑誌)

Miliary tuberculosis not affecting the lungs but complicated by acute respiratory distress syndrome.
 Int. Med. (I. Miyoshi, M. Daibata, N. Kuroda, H. Taguchi, H. Enzan.) 44/, 622-624 2005 (学術雑誌)

Alterations of DNA damage-response genes ATM and ATR in pyothorax-associated lymphoma.
 Lab. Invest. (A. Liu, T. Takakuwa, S. Fujita, M. F. Ham, W. J. Luo, M. Daibata, K. Aozasa.) 85/, 436-446 2005 (学術雑誌)

Bone marrow necrosis.
 Br. J. Haematol. (I. Miyoshi, M. Daibata, Y. Ohtsuki, H. Taguchi.) 130/, 467 2005 (学術雑誌)

Chronic disseminated intravascular coagulation associated with abdominal aortic aneurysm.
 Int. Med. (I. Miyoshi, M. Daibata, H. Taguchi.) 44/, 771 2005 (学術雑誌)

Viral pneumonia: Coinfection of Cytomegarovirus and herpes simplex virus.
 Int. Med. (I. Miyoshi, M. Daibata, H. Taguchi, Y. Ohtsuki.) 44/, 518-519 2005 (学術雑誌)

Lymphoma associated with Epstein-Barr virus-positive pyothorax.
 Int. Med. (M. Daibata, T. Saito, H. Machida, I. Miyoshi, H. Taguchi.) 43/, 1210-1211 2004 (学術雑誌)

Absence of human herpesvirus 8 in lung tissues from Japanese patients with primary pulmonary hypertension.
 Res. Med. (M. Daibata, I. Miyoshi, H. Taguchi, H. Matsubara, H. Date, N. Shimizu, Y. Ohtsuki.) 98/, 1231-1232 2004 ()

Non-multiple lymphomatous polyposis form of mantle cell lymphoma in the gastrointestinal tract.
 J. Gastroenterol. (S. Tamura, K. Ohkawauchi, Y. Yokoyama, Y. Higashidani, M. Daibata, M. Hiroi, S. Yamamori, S. Onishi.) 39/, 995-1000 2004 (学術雑誌)

Differential gene-expression profiling in the leukemia cell lines derived from indolent and aggressive phases of CD56+ T-cell large granular lymphocyte leukemia.
 Int. J. Cancer (M. Daibata, Y. Matsuo, H. Machida, T. Taguchi, Y. Ohtsuki, H. Taguchi.) 108/, 845-851 2004 (学術雑誌)

Pure red cell aplasia in a patient with trisomy X chromosome abnormality and reactivated Epstein-Barr virus infection.
 Int. J. Hematol. (M. Daibata, H. Machida, Y. Nemoto, H. Taguchi.) 77/, 354-358 2003 (学術雑誌)

Epstein-Barr virus in concomitant gastric carcinoma and adult T-cell leukemia/lymphoma.
 Am. J. Med. (M. Daibata, Y. Nemoto, S. Takemoto, I. Miyoshi, H. Taguchi.) 114/, 509-510 2003 (学術雑誌)

Simian virus 40 in Japanese patients with lymphoproliferative disorders.
 Bri. J. Haematol. (M. Daibata, Y. Nemoto, M. Kamioka, S. Imai, H. Taguchi.) 121/, 190-191 2003 (学術雑誌)

The novel t(11;12;18)(q21;q13;q21) represents a variant translocation of the t(11;18)(q21;q21) associated with MALT-type lymphoma.
 Leukemia (J. Dierlamm, E. M. M. Penas, M. Daibata, H. Tagushi, K. Hinz, M. Baens, J. Cools, G. Schilling, L. Michaux, P. Marynen, I. Miyoshi, D. K. Hossfeld.) 16/, 1863-1864 2002 (学術雑誌)

Malignant lymphoma with human herpesvirus 6-positive multifocal leukoencephalopathy.
 Review Series: Oncology. (M. Daibata, N. Hatakeyama, M. Kamioka, Y. Nemoto, M. Hiroi, I. Miyoshi, H. Taguchi.) 1/, 11-13 2002 (学術雑誌)

Human herpesvirus 6 and adult-onset Still's disease.
 Am. J. Med. (M. Daibata, H. Taguchi.) 113/, 532 2002 (学術雑誌)

A novel chromosome translocation (16;20)(q22;p13) in polycythemia vera.
 Cancer Genet. Cytogenet. (M. Daibata, T. Taguchi, H. Taguchi.) 137/, 29-32 2002 (学術雑誌)

Human herpesvirus 6 in progressive multifocal leukoencephalopathy.
 Review Series: Infectious Diseases. (M. Daibata.) 2/, 10-11 2002 (学術雑誌)

Epstein-Barr virus (EBV)-positive pyothorax-associated lymphoma (PAL): chromosomal integration of EBV in a novel CD2-positive PAL B-cell line.
 Br. J. Haematol. (M. Daibata, T. Taguchi, Y. Nemoto, T. Saito, H. Machida, S. Imai, I. Miyoshi, H. Taguchi.) 117/, 546-557 2002 (学術雑誌)

Detection of human herpesvirus 6 and JC virus in progressive multifocal leukoencephalopathy complicating follicular lymphoma.
 Am. J. Hematol. (M. Daibata, N. Hatakeyama, M. Kamioka, Y. Nemoto, M. Hiroi, I. Miyoshi, and H. Taguchi.) 67/, 200-205 2001 (学術雑誌)

Lactate dehydrogenase production and release in a newly established human myeloma cell line.
 Am. J. Hematol. (N. Hatakeyama, M.Daibata, Y. Nemoto, Y. Ohtsuki, H. Taguchi.) 66/, 267-273 2001 (学術雑誌)

Genomic organization, tissue expression, and cellular localization of AF3p21, a fusion partner of MLL in therapy-related leukemia.
 Genes Chrom. Cancer (A. Hayakawa, Y. Matsuda, M. Daibata, H. Nakamura, K. Sano.) 30/, 364-374 2001 (学術雑誌)

Presence of human herpesvirus 6 DNA in somatic cells.
 Blood (M. Daibata, T. Taguchi, K. Miyoshi, H. Taguchi, I. Miyoshi.) 95/, 1108-1109 2000 (学術雑誌)

Constitutional t(3;11)(p21;q23) in a family, including one member with malignant lymphoma: Establishment of novel cell lines with this translocation.
 Cancer Genet. Cytogenet. (M. Daibata, Y. Nemoto, N. Komatsu, H. Machida, I. Miyoshi, H. Taguchi.) 117/, 28-31 2000 (学術雑誌)

Co-infection of HHV-6 and HHV-8 is rare in primary effusion lymphoma.
 Leukemia Res. (H. Asou, T. Tasaka, J. W. Said, M. Daibata, N. Kamada, H. P. Koeffler.) 24/, 59-61 2000 (学術雑誌)

Human herpesviruses in primary ocular lymphoma.
 Leukemia and Lymphoma (M. Daibata, T. Komatsu, H. Taguchi.) 37/, 361-365 2000 (学術雑誌)

Inheritance of chromosomally integrated human herpesvirus 6 DNA.
 Blood (M. Daibata, T. Taguchi, Y. Nemoto, H. Taguchi, I. Miyoshi.) 94/, 1545-1549 1999 (学術雑誌)

Human herpesvirus 7 and lymphocytic leukaemia.
 Br. J. Haematol. (M. Daibata, M. Kamioka, H. Wakiguchi, I. Miyoshi, H. Taguchi.) 104/, 934 1999 (学術雑誌)

Presence of human herpesvirus 6 DNA in cord blood cells.
 J. Infect. Dis. (M. Daibata, I. Miyoshi.) 179/, 1046-1047 1999 (学術雑誌)

Integration of human herpesvirus 6 DNA in lymphoproliferative disorders and its transmission.
 In: Recent Research Developments in Virology (S.G. Pandalai, ed.). Transworld Research Network (Trivandrum, India) (M. Daibata.) 1/, 1-6 1999 (学術雑誌)

Integration of human herpesvirus 6 genome in human chromosomes.
 Lancet (M. Daibata, T. Taguchi, H. Taguchi, I. Miyoshi.) 352/, 1707-1708 1998 (学術雑誌)

Chromosomal transmission of human herpesvirus 6 DNA in acute lymphoblastic leukaemia.
 Lancet (M. Daibata, T. Taguchi, T. Sawada, H. Taguchi, I. Miyoshi.) 352/, 543-544 1998 (学術雑誌)

Lymphoblastoid cell lines with integrated human herpesvirus 6.
 J. Hum. Virol. (M. Daibata, T. Taguchi, I. Kubonishi, H. Taguchi, I. Miyoshi.) 1/, 475-481 1998 (学術雑誌)

Integration of human herpesvirus 6 in a Burkitt’s lymphoma cell line.
 Br. J. Haematol. (M. Daibata, T. Taguchi, H. Taguchi, I. Miyoshi.) 102/, 1307-1313 1998 (学術雑誌)

Identification of integrated human herpesvirus 6 DNA in early pre-B cell acute lymphoblastic leukemia.
 Leukemia (M. Daibata, T. Taguchi, M. Kamioka, I. Kubonishi, H. Taguchi, I. Miyoshi.) 12/, 1002-1005 1998 (学術雑誌)

Human herpesvirus 8 in premalignant and cancerous skin lesions in a Japanese patient with adult T-cell leukaemia.
 Br. J. Haematol. (M. Daibata, M. Chikazawa, H. Taguchi, I. Miyoshi.) 100/, 802-803 1998 (学術雑誌)

Analysis of the Smad2 gene in hematological malignancies.
 Leukemia (T. Ikezoe, S. Takeuchi, M. Kamioka, M. Daibata, I. Kubonishi, H. Taguchi, I. Miyoshi.) 12/, 94-95 1998 (学術雑誌)

Human herpesvirus 8 in Kaposi’s sarcoma of an HIV-negative Japanese woman with adult T-cell leukaemia.
 Br. J. Haematol. (M. Daibata, Y. Kawachi, I. Miyoshi.) 97/, 507-508 1997 (学術雑誌)

Human herpesvirus 6 (HHV-6)-positive Burkitt’s lymphoma: Establishment of a novel cell line infected with HHV-6.
 Blood (K. Bandobashi, M. Daibata, M. Kamioka, Y. Tanaka, I. Kubonishi, H. Taguchi, Y. Ohtsuki, I. Miyoshi.) 90/, 1200-1207 1997 (学術雑誌)

Angioimmunoblastic lymphadenopathy with disseminated human herpesvirus 6 infection in a patient with acute myeloblastic leukemia.
 Leukemia (M. Daibata, E. Ido, K. Murakami, T. Kuzume, H. Taguchi, I. Miyoshi.) 11/, 882-895 1997 (学術雑誌)

Expression of Fas and apotosis of a Hodgkin’s disease cell line (HD-70).
 Int. J. Hematol. (I.Kubonishi, M. Daibata, I. Sakuma, T. Yoshino, H. Sonobe, Y. Ohtsuki, I. Miyoshi.) 65/, 305-307 1997 (学術雑誌)

High serum levels of CA125 and interleukin-6 in a patient with Ki-1 lymphoma.
 Br. J. Haematol. (I. Kubonishi, K. Bandobashi, N. Murata, M. Daibata, E. Ido, H. Sonobe, Y. Ohtsuki, I. Miyoshi.) 98/, 450-452 1997 (学術雑誌)

Differential tumorigenicity between Epstein-Barr virus genome-positive and genome-negative cell lines with t(11;14)(q13;q32) derived from mantle cell lymphoma.
 J. Virol. (M. Daibata, I. Kubonishi, I. Miyoshi.) 70/, 9003-9007 1996 (学術雑誌)

Antisense oligodexynucleotides against the BZLF1 transcript inhibit induction of productive Epstein-Barr virus replication.
 Antiviral Res. (M. Daibata, E.-M. Enzinger, J. E. Monroe, R. E. Kilkuskie, A. K. Field, C. Mulder.) 29/, 243-260 1996 (学術雑誌)

Regulation of the BZLF1 promoter of Epstein-Barr virus by second messengers in anti-immunoglobulin treated B cells.
 Virology (M. Daibata, S. H. Speck, C. Mulder, T. Sairenji.) 198/, 446-454 1994 (学術雑誌)

More efficient peptide binding to MHC class II molecules during cathepsin B digestion of Ii than after Ii release.
 Mol. Immunol. (M. Daibata, M. Xu, R. E. Humphreys, V. E. Reyes.) 31/, 255-260 1994 (学術雑誌)

Cathepsin B cleavage and release of invariant chain from MHC class II molecules follow a staged pattern.
 Mol. Immunol. (M. Xu, G. A. Capraro, M. Daibata, V. E. Reyes, R. E. Humphreys.) 31/, 723-731 1994 (学術雑誌)

Invariant chain dissociation from class II MHC is a catalyst for foreign peptidebinding.
 Annal. NY. Acad. Sci. (V. E. Reyes, M. Daibata, R. Espejo, R. E. Humphreys.) 730/, 338-341 1994 (学術雑誌)

Charging of peptides to MHC class II molecules during proteolysis of Ii.
 In Antigen Processing and Presentation (R. E. Humphreys and S. K. Pierce, eds.). Academic Press (San Diego, CA) (M. Xu, M. Daibata, S. Adams, R. E. Humphreys, V. E. Reyes.) /, 227-241 1994 (学術雑誌)

Epstein-Barr virus (EBV) replication and expressions of EA-D (BMRF1 gene product), virus-specific deoxyribonuclease and DNA polymerase in EBV-activated Akata cells.
 Virology (M. Daibata, T. Sairenji.) 196/, 900-904 1993 (学術雑誌)

Phosphorylation of the Epstein-Barr virus BZLF1 immediate-early gene product ZEBRA.
 Virology (M. Daibata, R. E. Humphreys, T. Sairenji.) 188/, 916-920 1992 (学術雑誌)

Effect of genistein, a tyrosine kinase inhibitor, on latent Epstein-Barr virus activation induced by crosslinkage of membrane IgG in Akata B cells.
 J. Immunol. (M. Daibata, I. Mellinghoff, S. Takagi, R. E. Humphreys, T, Sairenji.) 147/, 292-297 1991 (学術雑誌)

EBV activation by anti-IgG-triggered, second messenger pathways.
 In: Epstein-Barr Virus and Human Disease (D.V. Albashi, ed.). Human Press (Clifton, NJ) (M. Daibata, S. Takagi, R. E. Humphreys, K. Takada, T. Sairenji.) /, 305-309 1991 ()

Intracellular localization of tyrosine kinase substrates beneath crosslinked surface immunoglobulins in B cells.
 J. Exp. Med. (S. Takagi, M. Daibata, T. J. Last, R. E. Humphreys, D. C. Parker, T. Sairenji.) 174/, 381-388 1991 (学術雑誌)

Relating homology between the Epstein-Barr virus BOLF1 molecule and HLA-DQw8 β chain to recent onset type I (insulin-dependent) diabetes mellitus.
 Diabetologia (T. Sairenji, M. Daibata, C. H. Sorli, H. Qvistback, R. E. Humphreys, J. Ludvigsson, J. Palmer, M. Landin-Olsson, G. Sundkvist, B. Michelson, A. Lernmark, T. Dyrberg.) 34/, 33-39 1991 (学術雑誌)

Early events in Epstein-Barr virus genome expression after activation: Regulation by second messengers of B cell activation.
 Virology (Mellinghoff, M. Daibata, R. E. Humphreys, C. Mulder, K. Takada, T. Sairenji.) 185/, 922-928 1991 (学術雑誌)

Establishment of a new Epstein-Barr virus nuclear antigen-positive B cell line, BALL-2, with t(8;14)(q24;q32) chromosome abnormality from B-cell acute lymphoblastic leukemia, L2.
 Amer. J. Hematol. (Kubonishi, M. Daibata, S. Yano, M. Isobe, N. Kurosawa, H. Nagumo, Z. Ogita, J. H. Ohyashiki, K. Toyama, I. Miyoshi.) 37/, 179-185 1991 (学術雑誌)

Activation of latent Epstein-Barr virus via anti-IgG-triggered, second messenger pathways in the Burkitt's lymphoma cell line Akata.
 J. Immunol. (M. Daibata, R. E. Humphreys, K. Takada, T. Sairenji.) 144/, 4788-4793 1990 (学術雑誌)

The establishment of Epstein-Barr virus nuclear antigen-positive (SP-50B) and Epstein-Barr virus nuclear antigen-negative (SP-53) cell lines with t(11;14)(q13;q32) chromosome abnormality from an intermediate lymphocytic lymphoma.
 Cancer (M. Daibata, I. Kubonishi, T. Eguchi, S. Yano, Y. Ohtsuki, I. Miyoshi.) 64/, 1248-1253 1989 (学術雑誌)

Serial transplantation of an HTLV-I-transformed hamster lymphoid cell line into hamsters.
 Int. J. Cancer (T. Eguchi, I. Kubonishi, M. Daibata, S. Yano, J. Imamura, Y. Ohtsuki, I. Miyoshi.) 41/, 868-872 1988 (学術雑誌)

Generalized lymph node metastasis of early uterine cancer in an HTLV-I carrier.
 Cancer (H. Taguchi, M. Daibata, T. Kitagawa, I. Kubonishi, M. Asai, Y. Sagara, H. Enzan, H. Hara, I. Miyoshi.) 62/, 2614-2716 1988 (学術雑誌)

Establishment of a new human B cell line carrying t(11;14) chromosome abnormality.
 Jpn. J. Cancer Res. (M. Daibata, M. Takasaki, S. Hirose, I. Kubonishi, H. Taguchi, Y. Ohtsuki, I. Miyoshi.) 78/, 1182-1185 1987 (学術雑誌)

Gastric lymphoma associated with human T-cell leukemia virus type I.
 Arch. Int. Med. (Kubonishi, M. Daibata, M. Fujishita, H. Taguchi, I. Miyoshi.) 147/, 603-605 1987 (学術雑誌)

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