■ 氏名
佐藤 隆幸 (サトウ タカユキ)
SATO Takayuki

■ 所属部局/職名
Research and Education Faculty, Medical Sciences Cluster, Basic Medicine Unit/Professor
教育研究部 医療学系 基礎医学部門/教授

■ 学部・学科・コース等
Medical School, Medical Course, Department of Physiology
医学部 医学科 生理学

■ 連絡先
住 所
電 話
F A X
E-Mail
U R L

■ 出身大学院・研究科等

■ 出身学校・専攻等
高知医科大学 (医学部 医学科) 1985 (卒業)

■ 取得学位
医学博士 (論文) 高知医科大学 循環器内科学

■ 研究職歴
1988-1994 高知医科大学 助手
1994-2000 国立循環器病センター研究所 研究員
2000-2003 高知医科大学 教授
2003- 高知大学医学部 教授


■ 委員歴・役員歴

■ 受賞学術賞
高知県産業振興計画賞 血管可視化装置「Mill Suss」高知県知事・公益財団法人高知県産業振興センター(大学発ベンチャーで設立した 株式会社プラス・メッドが受賞) (2017)
科学技術賞 開発部門「画期的な手術ナビゲーションシステムの開発」文部科学大臣 (2013)
国際画像セミナー日本映像処理研究会賞「注射の悩み解決します:近赤外蛍光インプラントの可能性」 (2012)
情報生活維新優秀賞(在宅介護・医療遠隔支援システムの構築) (2005)

■ 所属学会
日本生理学会
 ( 国内)

■ 専門分野
医用工学、神経制御学

■ 主な研究テーマ・活動
循環制御機構の解明と機能再建および機能再生学

■ 研究についてのPR
 循環器は、生体内での物流機構としてはたらき、一刻の機能停止も許されない。したがって、循環器疾患の治療においては、機能を再建することが必須である。
 研究においては、「いかにこの物流機構を制御して機能を保つか」に主眼をおき、循環器疾患の新しい治療技術を開発している。開発には、細胞生物学、循環生理学などの医学分野の技術とシステム工学、情報工学などの工学分野の技術を融合し、総合的・体系的におこなっている。たとえば、
 ・ヒトの血圧を自在にあやつる:循環生理学の知識と制御工学の融合
 ・細胞から心臓をつくる:細胞生物学と機械工学の融合
 ・神経刺激で心臓病による突然死を防止する:循環生理学と電気工学の融合
などがある。

■ 社会人・生徒を対象として可能な講演・授業(例えば講演題目)
 ・ヒトの血圧を自在にあやつる:循環生理学の知識と制御工学の融合
 ・細胞から心臓をつくる:細胞生物学と機械工学の融合
 ・神経刺激で心臓病による突然死を防止する:循環生理学と電気工学の融合

■ 研究業績(論文・解説)
New quantitative analysis method using HyperEye Medical System image for coronary artery bypass grafting.
 Angioloy. (Handa T, Orihashi K, Nishimori H, Yamamoto M, Sato T.) 5/, 2 2017 (学術雑誌)

Influence of vessel stenosis on indocyanine green fluorescence intensity assessed by near-infrared fluorescence angiography.
 Surg Today. (Yamamoto M, Nishimori H, Fukutomi T, Handa T, Kihara K, Tashiro M, Sato T, Orihashi K.) 47/877, 882 2017 (学術雑誌) DOI: 10.1007/s00595-016-1453-y

Quantitative assessment technique of HyperEye medical system angiography for coronary artery bypass grafting.
 Surg Today. (Yamamoto M, Nishimori H, Handa T, Fukutomi T, Kihara K, Tashiro M, Sato T, Orihashi K.) 47/2, 201-217 2017 (学術雑誌) doi: 10.1007/s00595-016-1369-6.

Donepezil, an acetylcholinesterase inhibitor, attenuates LPS-induced inflammatory response in murine macrophage cell line RAW 264.7 through inhibition of nuclear factor kappa B translocation.
 Eur J Pharmacol. (Arikawa M, Kakinuma Y, Noguchi T, Todaka H, Sato T. ) 789/17, 26 2016 (学術雑誌) 10.1016/j.ejphar.2016.06.053

Recent advances in near-infrared fluorescence-guided imaging surgery using indocyanine green.
 Surg Today. (Namikawa T, Sato T, Hanazaki K.) 45/12, 1467 2015 (学術雑誌) 10.1007/s00595-015-1158-7

Efficacy of intraoperative HyperEye Medical System angiography for coronary artery bypass grafting.
 Surg Today. (Yamamoto M, Orihashi K, Nishimori H, Handa T, Kondo N, Fukutomi T, Sato T.) 45/8, 966 2015 (学術雑誌) 10.1007/s00595-014-1015-0

迷走神経刺激療法の基礎と臨床
 細胞 (佐藤隆幸) 47/7, 14 2015 (その他)

Acetylcholine suppresses ventricular arrhythmias and improves conduction and connexin-43 properties during myocardial ischemia in isolated rabbit hearts.
 J Cardiovasc Electrophysiol. (Aiba T, Noda T, Hidaka I, Inagaki M, Katare RG, Ando M, Sunagawa K, Sato T, Sugimachi M.) 26/6, 678 2015 (学術雑誌)

近赤外光および近赤外蛍光の医療イメージングへの応用
 Medical & Imaging (佐藤隆幸) /2, 31 2015 (その他)

Treatment of a large, symptomatic refractory lymphocele after pelvic lymphadenectomy by using the hypereye medical system TM.
  J Gynecol Surg. (Ushiwaka T, Maeda N, Kunimi Y, Sugimoto T, Hanazaki K, Sato T, Fukata T. ) 31/61, 65 2015 (学術雑誌)

Successful preservation of the mesenteric and bowel circulation with treatment for a ruptured superior mesenteric artery aneurysm using the HyperEye Medical System.
 Am Surg. (Namikawa T, Uemura S, Kondo N, Yamamoto M, Maeda H, Nishimori H, Sato T, Orihashi K, Kobayashi M, Hanazaki K.) 80/12, e359 2015 (学術雑誌)

血圧の自律神経制御と起立性低血圧
 Clinical Neuroscience  (佐藤隆幸) 32/, 1354-1357 2014 (学術雑誌)

Donepezil, therapeutic acetylcholinesterase inhibitor, prevents the progression of ventricular dysfunction by promoting myocardial glucose utilization in rat model of chronic heart failure following myocardial infarction.
 Cardiol Pharmacol. (Arikawa M, Kakinuma Y, Noguchi T, Sato T.) 3/2, 1000121 2014 (学術雑誌) 10.4172/2329-6607.1000121

Donepezil can improve ischemic muscle atrophy by activating angiomyogenic properties of satellite cells.
 Circ J. (Noguchi T, Kakinuma Y, Arikawa M, Okazaki K, Hoshino E, Iiyama T, Kubo T, Kitaoka H, Doi Y, Sato T.) 78/, 2317-2324 2014 (学術雑誌) 10.1253/circj.CJ-14-0095

Less deep vein thrombosis due to transcutaneous fibular nerve stimulation in total knee arthroplasty: a randomized controlled trial.
 Knee Surg Sports Traumatol Arthrosc. (Izumi M, Ikeuchi M, Aso K, Sugimura N, Kamimoto Y, Mitani T, Ueta T, Sato T, Yokoyama M, Sugiura T, Tani T.) 23/11, 3317 2014 (学術雑誌) 10.1007/s00167-014-3141-z

Antimuscle atrophy effect of nicotine targets muscle satellite cells partly through an α7 nicotinic receptor in a murine hindlimb ischemia model.
 Transl Res. (Kakinuma Y, Noguchi T, Okazaki K, Oikawa S, Iketani M, Kurabayashi M, Furihata M, Sato T. ) 164/, 32-45 2014 (学術雑誌) 10.1016/j.trsl.2014.02.005.

Successful treatment of non-occlusive mesenteric ischemia (NOMI) using the HyperEye Medical System™ for intraoperative visualization of the mesenteric and bowel circulation: report of a case.
 Surg Today. (Nitori N, Deguchi T, Kubota K, Yoshida M, Kato A, Kojima M, Kadomura T, Okada A, Okamura J, Kobayashi M, Sato T, Beck Y, Kitagawa Y, Kitajima M.) 44/, 359-362 2014 (学術雑誌) 10.1007/s00595-013-0503-y

Conditional VHL gene deletion causes hypoglycemic death associated with disproportionately increased glucose uptake by hepatocytes through an upregulated IGF-I receptor.
 PLoS One. (Kurabayashi A, Kakinuma Y, Morita T, Inoue K, Sato T, Furihata M. ) 8/7, e69139 2013 (学術雑誌) 10.1371/journal.pone.0069139.

近赤外光の医療応用-外科医をサポートする映像技術
 電子版 ビオフィリア (佐藤隆幸) 1/, 49-56 2013 (その他)

Heart-specific overexpression of choline acetyltransferase gene protects murine heart against ischemia through hypoxia-inducible factor-1α-related defense mechanisms.
 J Am Heart Assoc. (Kakinuma Y, Tsuda M, Okazaki K, Akiyama T, Arikawa M, Noguchi T, Sato T.) 2/1, e004887 2013 (学術雑誌) 10.1161/JAHA.112.004887.

近赤外蛍光カラーイメージングシステムの製品化事例
 医療機器学 (佐藤隆幸) 82/6, 463 2012 (学術雑誌)

A non-neuronal cardiac cholinergic system plays a protective role in myocardium salvage during ischemic insults.
 PLoS ONE (Kakinuma Y, Akiyama T, Okazaki K, Arikawa M, Noguchi T, Sato T.) 7/, e50761 2012 (学術雑誌) 10.1371/journal.pone.005076

自律神経失調症における起立性低血圧
 医学のあゆみ (佐藤隆幸) 82/6, 463 2012 (学術雑誌)

Influences of Donepezil on Cardiovascular System - Possible Therapeutic Benefits for Heart Failure - DOnepezil Cardiac TEst Registry (DOCTER) Study.
 J Cardiovasc Pharmacol. (Kubo T, Sato T, Noguchi T, Kitaoka H, Yamasaki F, Kamimura N, Shimodera S, Iiyama T, Kumagai N, Kakinuma Y, Diedrich A, Jordan J, Robertson D, Doi YL. ) 60/3, 310-314 2012 (学術雑誌)

Metabolic effect of combined telmisartan and nifedipine CR therapy in patients with essential hypertension.
 Int J Gen Med. (Shimizu Y, Yamasaki F, Fururo T, Kubo T, Sato T, Doi Y, Sugiura T.) 5/, 753-758 2012 (学術雑誌)

Indocyanine green injection for detecting sentinel nodes using color fluorescence camera in the laparoscopy-assisted gastrectomy.
 J Gastroenterol Hepatol (Yoshida M, Kubota K, Kuroda J, Ohta K, Nakamura T, Saito J, Kobayashi M, Sato T, Beck Y, Kitagawa Y, Kitajima M.) 27/, 29 2012 (学術雑誌) 10.1111/j.1440-1746.2012.07067.x.

Indocyanine green angiography for intra-operative assessment in vascular surgery.
 Eur J Vasc Endovasc Surg (Yamamoto M, Orihashi K, Nishimori H, Wariishi S, Fukutomi T, Kondo N, Kihara K, Sato T, Sasaguri S. ) 43/, 426 2012 (学術雑誌) 10.1016/j.ejvs.2011.12.030

Conditional VHL gene deletion activates a local NO-VEGF axis in a balanced manner reinforcing resistance to endothelium-targeted glomerulonephropathy.
 Nephrol Dial Transplant (Morita T, Kakinuma Y*, Kurabayashi A, Fujieda M, Sato T, Shuin T, Furihata M, Wakiguchi H) 26/, 4023 2011 (学術雑誌) 10.1093/ndt/gfr176

Assessing intraoperative blood flow in cardiovascular surgery.
 Surg Today (Yamamoto M, Sasaguri S, Sato T.) 41/, 1467 2011 (学術雑誌) 10.1007/s00595-010-4553-0

Donepezil, anti-Alzheimer’s disease drug, prevents cardiac rupture during acute phase of myocardial infarction in mice.
 PLoS ONE (Arikawa M, Kakinuma Y, Handa T, Yamasaki F, Sato T.) 6/, e20629 2011 (学術雑誌) 10.1371/journal.pone.0020629

HyperEye Medical System を用いた乳癌センチネルリンパ節生検手技.
 手術 (杉本健樹, 花崎和弘, 佐藤隆幸.) 65/, 421 2011 (学術雑誌)

Feasibility of ICG fluorescence-guided sentinel node biopsy in animal models using the HyperEye Medical System.
 Ann Sur Oncol. (Yamauchi K, Nagafuji H, Nakamura T, Sato T, Kohno N ) 18/, 2042 2011 (学術雑誌)

Effects of various doses of aspirin on platelet activity and endothelial function.
 Heart Vessels. (Furuno T, Yamasaki F, Yokoyama T, Sato K, Sato T, Doi Y, Sugiura T. ) 26/, 267 2011 (学術雑誌)

アルツハイマー病に用いられるドネペジルの抗心不全作用
 循環器内科 (佐藤隆幸) 68/, 496-498 2010 (学術雑誌)

Donepezil treatment and cardiovascular mortality.
 Clin Pharmacol Ther (Sato K, Urbano R, Yu C, Yamasaki F, Sato T, Jordan J, Robertson D, Diedrich A. ) 88/3, 335-338 2010 (学術雑誌)

Differential regulation of TNF receptors by vagal nerve stimulation protect heart against acute ischemic injury.
  J Mol Cell Cardiol (Katare RG, Ando M, Kakinuma Y, Arikawa M, Yamasaki F, Sato T. ) 49/, 234-244 2010 (学術雑誌)

Donepezil, an acetylcholinesterase inhibitor against Alzheimer’s dementia,promotes angiogenesis in an ischemic hindlimb model.
 J Mol Cell Cardiol (Kakinuma Y, Furihata M, Akiyama T, Arikawa M, Handa T, Katare RG, Sato T.) 48/, 680-693 2010 (学術雑誌)

Engineered heart tissue: A novel tool to study the ischemic changes of the heart In vitro.
 PLoS ONE (Katare RG, Ando M, Kakinuma Y, Sato T. ) 5/, e9275 2010 (学術雑誌)

A new device for the intraoperative graft assessment: The HyperEye charge-coupled device camera system.
 Gen Thorac Cardiovasc Surg. (Handa T, Katare RG, Nishimori H, Wariishi S, Fukutomi T, Yamamoto M, Sasaguri S, Sato T.) 58/, 68-77 2010 (学術雑誌)

Cholinoceptive and cholinergic properties of cardiomyocytes involving an amplification mechanism for vagal efferent effects in sparsely innervated ventricular myocardium.
 FEBS J (Kakinuma Y, Akiyama T, Sato T. ) 276/, 5111-5125 2009 (学術雑誌)

Anti-Alzheimer’s drug, donepezil, markedly improves long-term survival after chronic heart failure in mice.
 J Card Fail (Handa T, Katare RG, Kakinuma Y, Arikawa M, Ando M, Sasaguri S, Yamasaki F, Sato T. ) 15/, 805-811 2009 (学術雑誌)

Preliminary experience for the evaluation of the intraoperative graft patency with real color charge-coupled device camera system: an advanced device for simultaneous capturing of color and near-infrared images during coronary artery bypass graft.
 Interact Cardiovasc Thorac Surg (Handa T, Sasaguri S, Sato T.) 9/, 150-154 2009 (学術雑誌)

Faster and stronger vascular "Biotube" graft fabrication in vivo using a novel nicotine-containing mold.
 J Biomed Mater Res B Appl Biomater (Sakai O, Kanda K, Takamizawa K, Sato T, Yaku H, Nakayama Y.) 90/, 412-420 2009 (学術雑誌)

Chronic intermittent fasting improves the survival following large myocardial ischemia by activation of BDNF/VEGF/PI3K signaling pathway.
 J Mol Cell Cardiol (Katare RG, Kakinuma Y, Arikawa M, Yamasaki F, Sato T. ) 46/, 405-412 2009 (学術雑誌)

Donepezilを使用した容量負荷心不全マウスにおける心機能改善効果、生存率改善効果の検討.
 心臓 (半田武巳, カタレ,ラジェシュG, 柿沼由彦, 有川幹彦, 安藤元紀, 山崎文靖, 佐藤隆幸, 笹栗志朗.) 41/, 115-129 2009 (学術雑誌)

Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mitochondrial permeability transition pore independent of the bradycardiac effect.
 J Thorac Cardiovasc Surg (Katare RG, Ando M, Kakinuma Y, Arikawa M, Handa T, Yamasaki F, Sato T. ) 137/, 223-231 2009 (学術雑誌)

Biphasic elevation of bilirubin oxidation during myocardial ischemia reperfusion.
 Circ J (Yamamoto Ma, Maeda H, Hirose N, Yamamoto Mo, Nakagawa A, Radhakrishnan G, Katare RG, Sato T, Yamaguchi T, Sasaguri S.) 72/, 1520-1527 2008 (学術雑誌)

A HIF-1alpha-related gene involved in cell protection from hypoxia by suppression of mitochondrial function.
 FEBS Lett (Kakinuma Y, Katare RG, Arikawa M, Muramoto K, Yamasaki F, Sato T. ) 582/, 332-340 2008 (学術雑誌)

Granulocyte colony-stimulating factor activates Wnt signal to sustain gap junction function through recruitment of β-catenin and cadherin.
 FEBS Lett (Kuwabara M, Kakinuma Y, Katare RG, Ando M, Yamasaki F, Doi Y, Sato T. ) 581/, 4821-4830 2007 (学術雑誌)

Modification in the von Hippel-Lindau protein is involved in the progression of experimentally induced rat glomerulonephritis.
 Nephron Exp Nephrol (Kudo Y, Kakinuma Y, Iguchi M, Sato T, Sugiura T, Furihata M, Shuin T. ) 106/, e97-e106 2007 (学術雑誌)

不規則チルト法と平衡線図解法を用いた圧受容反射機能の評価
 自律神経 (安藤元紀, 山崎文靖, 佐藤隆幸) 44/, 229-235 2007 ()

脊髄刺激による血圧制御
 自律神経 (山崎文靖, 牛田享宏, 横山武志, 山下幸一, 安藤元紀, 佐藤隆幸) 44/, 236-242 2007 ()

Postexercise VO2 "Hump" phenomenon as an indicator for inducible myocardial ischemia in patients with acute anterior myocardial infarction.
 Int J Cardiol (Takaki H, Sakuragi S, Nagaya N, Suzuki S, Goto Y, Sato T, Sunagawa K. ) 111/, 67-74 2006 (学術雑誌)

Acetylcholine inhibits the hypoxia-induced reduction of connexin43 protein in rat cardiomyocytes.
 J Pharmacol Sci (Zhang Y, Kakinuma Y, Ando M, Katare RG, Yamasaki F, Sugiura T, Sato T. ) 101/, 214-222 2006 (学術雑誌)

Nitric oxide stimulates vascular endothelial growth factor production in cardiomyocytes involved in angiogenesis.
 J Physiol Sci (Kuwabara M, Kakinuma Y, Ando M, Katare RG, Yamasaki F, Doi Y, Sato T.) 56/, 95-101 2006 (学術雑誌)

Artificial baroreflex: Clinical application of a bionic baroreflex system.
 Circulation (Yamasaki F, Ushida T, Yokoyama T, Ando M, Yamashita K, Sato T. ) 113/, 634-639 2006 (学術雑誌)

バイオニック治療戦略
 循環器専門医 (佐藤隆幸, 砂川賢二) 14/, 9-15 2006 ()

Efferent vagal nerve stimulation protects heart against ischemia-induced arrhythmias by preserving connexin43 protein.
 Circulation (Ando M, Katare RG, KakinumaY, Zhang D, Yamasaki F, Muramoto K, Sato T. ) 112/, 164-170 2005 (学術雑誌)

Association between arterial stiffness and platelet activation.
 J Hum Hypertens (Yamasaki F, Furuno T, Sato K, Zhang D, Nishinaga M, Sato T, Doi Y, Sugiura T.) 19/, 527-533 2005 (学術雑誌)

Acetylcholine from vagal stimulation protects cardiomyocytes against ischemia and hypoxia involving additive nonhypoxic induction of HIF-1α.
 FEBS Lett (Kakinuma Y, Ando M, Kuwabara M, Katare RG, Okudela K, Kobayashi M, Sato T. ) 579/, 2111-2118 2005 (学術雑誌)

HIF-1α is involved in the attenuation of experimentally induced rat glomerulonephritis.
 Nephron Exp Nephrol (Kudo Y, Kakinuma Y, Mori Y, Morimoto N, Karashima T, Furihata M, Sato T, Shuin T, Sugiura T. ) 100/, e95-e103 2005 (学術雑誌)

バイオニック動脈圧反射による血圧コントロール
 循環器科 (佐藤隆幸) 58/, 600-605 2005 ()

A self-calibrating telemetry system for measurement of ventricular pressure-volume relations in conscious, freely moving rats.
 Am J Physiol (Uemura K, Kawada T, Sugimachi M, Zheng C, Kashihara K, Sato T, Sunagawa K.) 287/, H2906-H2913 2004 (学術雑誌)

Effect of electrical modification of cardiomyocytes on transcriptional activity through 5’AMP-activated protein kinase.
 J Cardiovasc Pharmacol (KakinumaY, Zhang Y, Ando M, Sugiura T, Sato T.) 44/, S435-S438 2004 (学術雑誌)

Bionic epidural stimulation restores arterial pressure regulation during orthostasis.
 J Appl Physiol (Yanagiya Y, Sato T, Kawada T, Inagaki M, Tatewaki T, Zheng C, Kamiya A, Takaki H, Sugimachi M, Sunagawa K.) 97/, 984-990 2004 (学術雑誌)

Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats.
 Circulation (Li M, Zheng C, Sato T, Kawada T, Sugimachi M, Sunagawa K. ) 109/, 120-124 2004 (学術雑誌)

神経インターフェイス技法を用いた心不全治療と術中血圧制御
 循環制御 (佐藤隆幸) 25/, 348-351 2004 ()

バイオニックラットからの提言:迷走神経の電気刺激療法
 循環制御 (佐藤隆幸) 25/, 23-27 2004 ()

Carotid-sinus baroreflex modulation of core and skin temperatures in rats: an open-loop approach.
 Jpn J Physiol (Zhang D, Ando M, Yamasaki F, Sato T. ) 53/, 461-466 2003 (学術雑誌)

Biphasic response of action potential duration to sudden sympathetic stimulation in anesthetized cats.
 Circ J (Tatewaki T, Inagaki M, Kawada T, Shishido T, Yanagiya Y, Takaki H, Sato T, Sugimachi M, Sunagawa K.) 67/, 876-880 2003 (学術雑誌)

Dynamics of sympathetic baroreflex control of arterial pressure in rats.
 Am J Physiol (Sato T, Kawada T, Sugimachi M, Sunagawa K. ) 285/, R262-R270 2003 (学術雑誌)

Identification of open-loop transfer functions in closed-loop baroreflex system using random breathing in humans.
 Comput Cardiol (Yingthawornsuk T, Kawada T, Sato T, Inagaki M, Sunagawa K, Cox J, Shiavi RG, Diedrich A. ) 9/, 461-464 2002 (学術雑誌)

Bionic technology revitalizes native baroreflex function in rats with baroreflex failure.
 Circulation (Sato T, Kawada T, Sugimachi M, Sunagawa K.) 106/, 730-734 2002 (学術雑誌)

Reduction in the endocochlear potential caused by Cs+ in the perilymph can be explained by the five-compartment model of the stria vascularis.
 Cell Tissue Res (Ando M, Takeuchi S, Kakigi A, Raicu V, Sato T.) 309/, 229-235 2002 (学術雑誌)

起立性低血圧の病態生理を識る.
 Heart View (山崎文靖, 佐藤隆幸, 奥宮清人, 土居義典) 6/, 1152-1158 2002 ()

Integrative sympathetic baroreflex regulation of arterial pressure.
 Ann N Y Acad Sci (Sunagawa K, Sato T, Kawada T. ) 940/, 314-323 2001 (学術雑誌)

Dynamic sympathetic control of atrioventricular conduction time and heart period.
 Am J Physiol (Kawada T, Chen SL, Inagaki M, Shishido T, Sato T, Tatewaki T, Sugimachi M, Sunagawa K. ) 280/, H1602-H1607 2001 (学術雑誌)

Non-Debye dielectric relaxation in biological structures arises from their fractal nature.
 Phys Rev (Raicu V, Sato T, Raicu G. ) E64/, 021916-1〜10 2001 (学術雑誌)

Three-dimensional and ultrastructural relationships between intermediate cells and capillaries in the gerbil stria vascularis.
 Hear Res (Takeuchi S, Ando M, Sato T, Kakigi A. ) 155/, 103-112 2001 (学術雑誌)

Chronic adriamycin treatment impairs myocardial interstitial neuronal release of norepinephrine and epinephrine.
 J Cardiovasc Pharmacol (Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Sugimachi M, Sunagawa K. ) 36/, S31-34 2000 (学術雑誌)

Counteraction of aortic baroreflex to carotid sinus baroreflex in a neck suction model.
 J Appl Physiol (Kawada T, Inagaki M, Takaki H, Sato T, Shishido T, Tatewaki T, Yanagiya Y, Sugimachi M, Sunagawa K.) 89/, 1979-1984 2000 (学術雑誌)

Single-beat estimation of end-systolic elastance using bilinearly approximated time-varying elastance curve.
 Circulation (Shishido T, Hayashi K, Shigemi K, Sato T, Sugimachi M, Sunagawa K. ) 102/, 1983-1989 2000 (学術雑誌)

Closed-loop identification of carotid sinus baroreflex transfer characteristics using electrical stimulation.
 Jpn J Physiol (Kawada T, Sato T, Inagaki M, Shishido T, Tatewaki T, Yanagiya Y, Zheng C, Sugimachi M, Sunagawa K. ) 50/, 371-380 2000 (学術雑誌)

Cyanide intoxication induced exocytotic epinephrine release in rabbit myocardium.
 J Auton Nerv Syst. (Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Inagaki M, Tatewaki T, Yanagiya Y, Sugimachi M, Sunagawa K. ) 80/, 137-141 2000 (学術雑誌)

Local epinephrine release in the rabbit myocardial interstitium in vivo.
  J Auton Nerv Syst (Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Yoshimura R, Inagaki M, Tatewaki T, Sugimachi M, Sunagawa K. ) 78/, 94-98 2000 (学術雑誌)

Increased brain angiotensin receptor in rats with chronic high-output heart failure.
 J Card Fail. (Yoshimura R, Sato T, Kawada T, Shishido T, Inagaki M, Miyano H, Nakahara T, Miyashita H, Takaki H, Tatewaki T, Yanagiya Y, Sugimachi M, Sunagawa K.) 6/, 66-72 2000 ()

Differential acetylcholine release mechanisms in the ischemic and non-ischemic myocardium.
 J Mol Cell Cardiol. (Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Inagaki M, Takaki H, Sugimachi M, Sunagawa K) 32/405, 414 2000 ()

A novel servo-control system that imposes desired aortic input impedance on in situ rat heart.
 Am J Physiol (Miyashita H, Sugimachi M, Sato T, Kawada T, Shishido T, Nakahara T, Yoshimura R, Takaki H, Miyano H, Sunagawa K) 278/, H998-H1007 2000 (学術雑誌)

バイオニック装置による中枢性動脈圧反射失調の機能再建.
 循環器病研究の進歩 (佐藤隆幸) 21/, 69-75 2000 ()

動脈圧変動 Mayer Wave の成因.
 Ther Res (佐藤隆幸, 川田 徹, 砂川賢二) 21/, 155-159 2000 ()

バイオニック動脈圧反射システム.
 日本 ME学会誌BME (佐藤隆幸, 砂川賢二. ) 13/, 15-20 1999 ()

交感神経制御型心臓ペースメーカの開発.
 日本ME学会誌BME (杉町 勝, 川田 徹, 稲垣正司, 宍戸稔聡, 佐藤隆幸, 砂川賢二. ) 13/, 10-14 1999 ()

統合的な枠組みにおける神経性の動脈圧制御.
 日本 ME学会誌BME (佐藤隆幸, 砂川賢二. ) 13/, 3-9 1999 ()

圧受容器反射を介した交感神経による動脈圧調節機構解析の新しい枠組み.
 Ther Res (川田 徹, 佐藤隆幸, 宍戸稔聡, 宮野博史, 稲垣正司, 杉町 勝, 砂川賢二. ) 20/, 145-150 1999 ()

Development of a servo-controller of heart rate using a cycle ergometer.
 Heart Vessels (Kawada T, Ikeda Y, Takaki H, Sugimachi M, Kawaguchi O, Shishido T, Sato T, Matsuura W, Miyano H, Sunagawa K.) 14/, 177-184 1999 ()

Development of a servo-controller of heart rate using a treadmill.
 Jpn Circ J (Kawada T, Sunagawa G, Takaki H, Shishido T, Miyano H, Miyashita H, Sato T, Sugimachi M, Sunagawa K.) 63/, 945-950 1999 (学術雑誌)

Dynamic counterbalance between direct and indirect vagal controls of atrioventricular conduction in cats.
 Am J Physiol (Chen SL, Kawada T, Inagaki M, Shishido T, Miyano H, Sato T, Sugimachi M, Takaki H, Sunagawa K. ) 277/, H2129-H2135 1999 (学術雑誌)

Summation of dynamic transfer characteristics of left and right carotid sinus baroreflexes in rabbits.
 Am J Physiol (Kawada T, Sato T, Shishido T, Inagaki M, Tatewaki T, Yanagiya Y, Sugimachi M, Sunagawa K.) 277/, H857-H865 1999 (学術雑誌)

Novel therapeutic strategy against central baroreflex failure: a bionic baroreflex system.
 Circulation (Sato T, Kawada T, Shishido T, Sugimachi M, Alexander J Jr, Sunagawa K. ) 100/, 299-304 1999 (学術雑誌)

Neuronal uptake affects dynamic characteristics of heart rate response to sympathetic stimulation.
 Am J Physiol (Nakahara T, Kawada T, Sugimachi M, Miyano H, Sato T, Shishido T, Yoshimura R, Miyashita H, Inagaki M, Alexander J Jr, Sunagawa K. ) 277/, R140-R146 1999 (学術雑誌)

New analytic framework for understanding sympathetic baroreflex control of arterial pressure.
  Am J Physiol (Sato T, Kawada T, Inagaki M, Shishido T, Takaki H, Sugimachi M, Sunagawa K.) 276/, H2251-H2261 1999 (学術雑誌)

Simultaneous identification of static and dynamic vagosympathetic interactions in regulating heart rate.
 Am J Physiol (Kawada T, Sugimachi M, Shishido T, Miyano H, Sato T, Yoshimura R, Miyashita H, Nakahara T, Alexander J Jr, Sunagawa K.) 276/, R782-R789 1999 (学術雑誌)

Acute effect of tumor necrosis factor-alpha is minimal on mechanics but significant on energetics in blood-perfused canine left ventricles.
  Crit Care Med (Miyano H, Shishido T, Kawada T, Miyashita H, Sato T, Sugimachi M, Sunagawa K.) 27/, 168-176 1999 (学術雑誌)

New simple methods for isolating baroreceptor regions of carotid sinus and aortic depressor nerves in rats.
 Am J Physiol (Sato T, Kawada T, Miyano H, Shishido T, Inagaki M, Yoshimura R, Tatewaki T, Sugimachi M, Alexander J Jr, Sunagawa K.) 276/, H326-H332 1999 (学術雑誌)

大動脈減圧神経の圧受容にみられるダイナミクス:ホワイトノイズ法による解析.
 循環器病研究の進歩 (佐藤隆幸, 川田 徹, 宮野博史, 宍戸稔聡, 稲垣正司, 杉町 勝, 砂川賢二. ) 19/, 43-50 1999 ()

Effect of diltiazem on sympathetic hyperactivity in patients with vasospastic angina as assessed by spectral analysis of arterial pressure and heart rate variability.
 Am J Cardiol (Yamasaki F, Sato T, Sugimoto K, Takata J, Chikamori T, Sasaki M, Doi Y.) 81/, 137-140 1998 (学術雑誌)

動脈圧反射からみた心不全.
 医学のあゆみ (佐藤隆幸, 砂川賢二. ) 187/, 821-826 1998 ()

Dynamic control of arterial blood pressure by the sympathetic baroreflex.
 Fundam Clin Pharmacol (Sunagawa K, Ikeda Y, Kawada T, Sugimachi M, Shishido T, Sato T, Miyano H, Matsuura W, Inagaki M, Alexander J Jr.) 12(Suppl 1)/, 23s-28s 1998 (学術雑誌)

Liquid chromatographic determination of myocardial interstitial epinephrine.
 J Chromatogr B Biomed Sci Appl (Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Sugimachi M, Inagaki M, Alexander J Jr, Sunagawa K.) 714/, 375-378 1998 (学術雑誌)

The brain is a possible target for an angiotensin-converting enzyme inhibitor in the treatment of chronic heart failure.
 J Card Fail (Sato T, Yoshimura R, Kawada T, Shishido T, Miyano H, Sugimachi M, Sunagawa K. ) 4/, 139-144 1998 (学術雑誌)

Cholinesterase affects dynamic transduction properties from vagal stimulation to heart rate.
 Am J Physiol (Nakahara T, Kawada T, Sugimachi M, Miyano H, Sato T, Shishido T, Yoshimura R, Miyashita H, Sunagawa K.) 275/, R541-R547 1998 (学術雑誌)

Accumulation of cAMP augments dynamic vagal control of heart rate.
 Am J Physiol (Nakahara T, Kawada T, Sugimachi M, Miyano H, Sato T, Shishido T, Yoshimura R, Miyashita H, Inagaki M, Alexander J Jr, Sunagawa K. ) 275/, H562-H567 1998 (学術雑誌)

Dynamic sympathetic regulation of left ventricular contractility studied in the isolated canine heart.
 Miyano H, Nakayama Y, Shishido T, Inagaki M, Kawada T, Sato T, Miyashita H, Sugimachi M, Alexander J Jr, Sunagawa K. (Am J Physiol) 275/, H400-H408 1998 (学術雑誌)

ESPVR of in situ rat left ventricle shows contractility-dependent curvilinearity.
  Am J Physiol (Sato T, Shishido T, Kawada T, Miyano H, Miyashita H, Inagaki M, Sugimachi M, Sunagawa K. ) 274/, H1429-H434 1998 (学術雑誌)

A new method to measure regional myocardial time-varying elastance using minute vibration.
 Am J Physiol (Shishido T, Sugimachi M, Kawaguchi O, Miyano H, Kawada T, Matsuura W, Ikeda Y, Sato T, Alexander J Jr, Sunagawa K.) 274/, H1404-H415 1998 (学術雑誌)

Dynamic transduction properties of in situ baroreceptors of rabbit aortic depressor nerve.
 Am J Physiol (Sato T, Kawada T, Shishido T, Miyano H, Inagaki M, Miyashita H, Sugimachi M, Knuepfer M M, Sunagawa K. ) 274/, H358-H365 1998 (学術雑誌)

Effects of nifedipine and enalapril on cardiac autonomic nervous function during the tilt test in elderly patients with hypertension.
 Hypertension Res (Okabayashi J, Matsubayashi K, Doi Y, Sato T, Ozawa T.) 20/, 1-6 1997 (学術雑誌)

ストレスに対する循環適応.
 バイオメカニズム学会誌 (佐藤隆幸, 砂川賢二. ) 21/, 65-68 1997 (学術雑誌)

(心筋と血管系リモデリング)序:心臓血管系のリモデリングとは.
 臨床科学 (佐藤隆幸, 砂川賢二. ) 33/, 1247-1251 1997 (学術雑誌)

Interstitial norepinephrine level by cardiac microdialysis correlates with ventricular contractility.
 Am J Physiol (Kawada T, Yamazaki T, Akiyama T, Shishido T, Miyano H, Sato T, Sugimachi M, Alexander J Jr, Sunagawa K.) 273/, H1107-H1112 1997 (学術雑誌)

Closed-loop identification of carotid sinus baroreflex open-loop transfer characteristics in rabbits.
 Am J Physiol (Kawada T, Sugimachi M, Sato T, Miyano H, Shishido T, Miyashita H, Yoshimura R, Takaki H, Alexander J Jr, Sunagawa K. ) 273/, H1024-H1031 1997 (学術雑誌)

Vagal stimulation decreases left ventricular contractility mainly through negative chronotropic effect.
 Am J Physiol (Matsuura W, Sugimachi M, Kawada T, Sato T, Shishido T, Miyano H, Nakahara T, Ikeda Y, Alexander J Jr, Sunagawa K.) 273/, H534-H539 1997 (学術雑誌)

Inhibition of NO synthesis does not potentiate dynamic cardiovascular response to sympathetic nerve activity.
 Am J Physiol (Miyano H, Kawada T, Sugimachi M, Shishido T, Sato T, Alexander J Jr, Sunagawa K. ) 273/, H38-H43 1997 (学術雑誌)

Inhibition of NO synthesis minimally affects the dynamic baroreflex regulation of sympathetic nerve activity.
 Am J Physiol (Miyano H, Kawada T, Shishido T, Sato T, Sugimachi M, Alexander J Jr, Sunagawa K. ) 272/, H2446-H2452 1997 (学術雑誌)

Inhibition of NO synthesis minimally affects the dynamic baroreflex regulation of sympathetic nerve activity.
 Am J Physiol (Miyano H, Kawada T, Shishido T, Sato T, Sugimachi M, Alexander J Jr, Sunagawa K. ) 272/, H2446-H2452 1997 (学術雑誌)

Dynamic vagosympathetic interaction augments heart rate response irrespective of stimulation patterns.
 Am J Physiol (Kawada T, Sugimachi M, Shishido T, Miyano H, Ikeda Y, Yoshimura R, Sato T, Takaki H, Alexander J Jr, Sunagawa K. ) 272/, H2180-H2187 1997 (学術雑誌)

Neural arc of baroreflex optimizes dynamic pressure regulation in achieving both stability and quickness.
 Am J Physiol (Ikeda Y, Kawada T, Sugimachi M, Kawaguchi O, Shishido T, Sato T, Miyano H, Matsuura W, Alexander J Jr, Sunagawa K. ) 271/, H882-H890 1996 ()

Power spectral analysis of spontaneous blood pressure and heart rate variability in elderly hypertensives.
 Hypertension Res (Aono T, Sato T, Nishinaga M, Kawamoto A, Ozawa T. ) 19/, 9-16 1996 (学術雑誌)

Sympathetic hyperactivity in patients with vasospastic angina: assessment by spectral analysis of heart rate and arterial pressure variabilities.
 Jpn Circ J (Yamasaki F, Sato T, Takata J, Chikamori T, Ozawa T, Sasaki M, Doi Y. ) 60/, 10-16 1996 (学術雑誌)

心臓後負荷としての動脈インピーダンス.1995;9:2-10
 日本ME学会誌 BME (杉町 勝, 宍戸稔聡, 松浦 渉, 宮野博史, 川田 徹, 佐藤隆幸, 砂川賢二. ) 9/, 2-10 1995 (学術雑誌)

老人高血圧患者におけるニフェジピンとエナラプリルの自律神経活動に与える影響.
 日本老年医学会雑誌 (岡林旬子、松林公蔵、佐藤隆幸、小澤利男) 31/, 285-292 1994 (学術雑誌)

Centrally administered ouabain aggravates central sleep apneas.
 J Appl Physiol (Sato T, Tadokoro M, Kaba H, Saito H, Seto K, Takatsuji H. ) 74/, 545-548 1993 (学術雑誌)

Accuracy of a continuous blood pressure monitor based on arterial tonometry.
 Hypertension (Sato T, Nishinaga M, Kawamoto A, Ozawa T, Takatsuji H.) 21/, 866-874 1993 (学術雑誌)

Centrally administered ouabain aggravates rapid-eye-movement-sleep-related bradyarrhythmias in freely moving rats.
 Br J Pharmacol (Sato T, Seto K. ) 110/, 253-256 1993 (学術雑誌)

Influence of the electrical stimulation of the medial amygdala on adrenocortical sensitivity to adrenocorticotrophin in hypophysectomized rats.
 Exp Clin Endocrinol (Saito H, Sato T, Kaba H, Okutani F, Yu GZ, Seto K, Kimura F, Kawakami M, Roberts S.) 100/, 145-147 1992 (学術雑誌)

Electrophysiologic study of dysrhythmias after atrial operations in dogs.
 Ann Thorac Surg (Tamiya T, Yamashiro T, Hata A, Kuge K, Asano S, Sato T. ) 54/, 717-724 1992 (学術雑誌)

Influence of the electrical stimulation of the hypothalamus on adrenocortical steroidogenesis in hypophysectomized rats.
 Exp Clin Endocrinol (Saito H, Sato T, Kaba H, Tadokoro M, Edashige N, Seto K, Kimura F, Kawakami M. ) 99/, 110-112 1992 (学術雑誌)

Influence of microinjection of insulin into the ventromedial hypothalamus on acetate metabolism in rumen epithelium of sheep.
 Exp Clin Endocrinol (Saito H, Kaba H, Ohri A, Sato T, Seto K, Kimura F, Kawakami M, Black AL. ) 96/, 331-334 1990 (学術雑誌)

Influence of dorsal hippocampal stimulation and dorsal fornix lesions on hepatic glucose metabolism in rabbits.
 Exp Clin Endocrinol (Saito H, Kaba H, Sato T, Nojima K, Li CS, Seto K, Kimura F, Kawakami M. ) 96/, 113-116 1990 (学術雑誌)

Sleep apneas and cardiac arrhythmias in freely moving rats.
 Am J Physiol (Sato T, Saito H, Seto K, Takatsuji H.) 259/, R282-R287 1990 (学術雑誌)

Influence of electrical stimulation of the hypothalamus on ovarian steroidogenesis in hypophysectomized and adrenalectomized rats.
 Exp Clin Endocrinol (Saito H, Kaba H, Sato T, Kondo M, Takeshima Y, Edashige N, Seto K, Kawakami M. ) 95/, 259-261 1990 (学術雑誌)

Influence of electrical stimulation of the limbic structure on adrenocortical steroidogenesis in hypophysectomized rats.
 Exp Clin Endocrinol (Saito H, Kaba H, Sato T, Honmura A, Kawakami T, Seto K, Yamamoto H, Kawakami M. ) 94/, 387-390 1989 (学術雑誌)

Role of the suprachiasmatic nuclei of the hypothalamus on diurnal rhythm in cardiac arrhythmias.
 Heart Vessels (Otsuka K, Sato T, Saito H, Kaba H, Seto K, Yanaga T, Ogura H, Ozawa T.) 2/, 15-22 1986 (学術雑誌)

Influence of lesions in the limbic-hypothalamic system on metabolic response of pyruvate to daily repeated cold exposure in rabbits.
 Exp Clin Endocrinol (Seto K, Saito H, Otsuka K, Sato T, Otsuka K, Kawakami M. ) 86/, 223-232 1985 (学術雑誌)

Circadian rhythm of cardiac bradyarrhythmia episodes in rats.
 Chronobiologia (Otsuka K, Sato T, Saito H, Kaba H, Otsuka K, Seto K, Ogura H, Ozawa T. ) 12/, 11-28 1985 (学術雑誌)

Arrhythmogenic properties of paradoxical sleep.
 Am Heart J (Saito H, Otsuka K, Sato T, Yoshimatsu K, Kaba H, Seto K, Ichimaru Y, Sato Y, Yanaga T.) 105/, 875-877 1983 (学術雑誌)

■ 研究業績(著書)
Yamamoto M, Orihashi K, Sato T. Intraoperative indocyanine green imaging technique in cardiovascular surgery. In: Wilbert SA, editor. Artery Bypass. p. 81-97. (2013)
 出版社:InTech

佐藤隆幸. 自律神経失調症における起立性低血圧. 熊谷裕生 編. 別冊「医学のあゆみ」自律神経による調節とその破綻. 第1版, p81-86.(2013)
 出版社:医歯薬出版株式会社

PRIMER ON THE AUTONOMIC NERVOUS SYSTEM. 3nd ed.(2012)
 出版社:Elsevier Academic Press(USA)

牛田享宏, 山崎文靖, 横山武志, 佐藤隆幸. XV. 血圧コントロールシステムとしての脊髄電気刺激療法. 森本昌宏 編著「脊髄電気刺激療法」p213-220. (2008)
 出版社:克誠堂

佐藤隆幸. I.高血圧診療に必要な基礎知識. 1. 血圧とは?―血圧の生理― 2)血圧と臓器循環. 苅尾七臣・島田和幸 編集. 「新・心臓病診療プラクティス 11.高血圧を識る・個別診療に生かす」p17-18. (2008)
 出版社:文光堂

佐藤隆幸, Diedrich A, 砂川賢二. バイオニック圧反射. 「ロバートソン自律神経学」原著第2版 高橋 昭 他 監訳. p431-433. (2007)
 出版社:エルゼビア・ジャパン

山崎文靖, 西永正典, 杉浦哲朗, 佐藤隆幸. PWVに影響しうる要因とその機序. 血圧. 宗像正徳 編集. 「PWVを知る PWVで診る」p67-71. (2006)
 出版社:中山書店

Sato T, Diedrich A, Sunagawa K. Bionic Baroreflex. In: Robertson D et al. editors. Primer on the autonomic nervous system. 2nd ed. p. 423-425.(2004)
 出版社:Elsevier Academic Press(USA)

佐藤隆幸. 起立性低血圧の機序と治療. 柳澤信夫,篠原幸人,岩田 誠,清水輝夫,寺本 明 編. 「Annual Review 神経 2004」XV. 自律神経疾患. p301-306. (2004)
 出版社:中外医学社

佐藤隆幸. 橈骨動脈と大動脈の脳波の比較−伝達関数の意義.臨床動脈波研究会 小澤利男,増田善昭,山科 章 編.「脈をどう診るか−新しい脈波の臨床応用」p48-55. (2003)
 出版社:メジカルビュー社

佐藤隆幸, 砂川賢二. 情報型人工臓器の基礎. 浅野茂隆, 小澤和恵, 藤正 巌 編. 岩波講座「現代医学の基礎」第14巻「移植と人工臓器」 p159-p171. (2001)
 出版社:岩波書店

佐藤隆幸. 心臓血管系の調節. 管 弘之, 高木 都, 後藤葉一, 砂川賢二. 編著日本エム・イー学会編/ME教科書シリーズB-1 「心臓力学とエナジェティクス」p127-p140. (2000)
 出版社:コロナ社

■ 研究業績(口頭・ポスター)

■ 研究業績(特許)
開口絞り
 EP Patent No.2454985

照明用開口絞り
 Chinese Patent No.ZL201180065496.5

樹脂組成物及び成形体
 特許第6188209号

熱可塑性樹脂組成物及び成形体
 特許第6188206号

撮像システム
 特許第6142389号

撮像システム
 Patent No.US 9625386

穿刺練習具
 特許第6061318号

樹脂組成物、成形体及び製造方法
 特許第6057486号

照明用開口絞り
 特許第5796244号

動脈可視化装置、および動脈撮像装置
 特許第5626943号

LED照射装置
 特許第5564654号

開口絞り
 US 8,711,461B2

撮像装置
 特許第5507376号

開口絞り
 特許第5418707号

開口絞り
 特許第5224078号

撮像装置
 特許第4971816号

撮像装置
 中国:ZL200810005302.2

虚血性疾患に対する血管新生促進治療薬
 特許第4888856号

心臓リモデリング抑制薬および心不全治療薬
 特許第4872044号

CARDIAC PACING SYSTEM, BLOOD PRESSURE REGULATING SYSTEM, AND CARDIAC DISEASE TREATMENT SYSTEM BY SUBSTITUTING NATIVE BIOLOGICAL REGULATORY FUNCTION
 US 7,962,216 B2

MEDICAL TREATMENT SYSTEM USING BIOLOGICAL REGULATION FUNCTION ALTERNATE, CARDIAC PACING SYSTEM BASED ON THE MEDICAL TREATMENT SYSTEM, BLOOD PRESSURE REGULATING SYSTEM, AND CARDIAC DISEASE TREATING SYSTEM.
 US 7,835,791 B2

生体圧迫装置及び血圧測定装置
 特許第4544917号

生体調節機能代替を用いた治療用システム
 特許第4189448号

Image pickup apparatus
 US 7,538,309 B2

動脈硬化評価装置
 特許第3692112号

マイクロ電極
 特許第3660823号

■ 研究業績(その他の活動)
新エネルギー・産業技術総合開発機構(NEDO)「未来医療を実現する先端医療機器・システムの研究開発」(2014-2019)受託研究等

高知県産学官連携産業創出研究推進事業(動脈・静脈穿刺ナビゲーション装置の開発)(2012-2014)受託研究等

科学技術振興機構 重点地域研究開発推進プログラム(育成研究)近赤外蛍光を捕捉する術中ナビゲーションカラーイメージングシステムの開発(2008-2009)受託研究等


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