■ 氏名
戸田 勝巳 (トダ カツミ)
TODA Katsumi

■ 所属部局/職名
Research and Education Faculty, Medical Sciences Cluster, Basic Medicine Unit/Associate Professor
教育研究部 医療学系 基礎医学部門/准教授

■ 学部・学科・コース等
Medical School, Medical Course, Department of Biochemistry
医学部 医学科 生化学

■ 連絡先
住 所
電 話088?880?2316
F A X
E-Mailtodak●med.kochi-u.ac.jp    (送信の際は“●”を半角の“@”に変更して送信してください。)
U R L

■ 卒業大学及び大学院等
北海道大学理学部卒業、北海道大学大学院理学研究科修了

■ 学位(種類)
理学博士

■ 所属学会
日本生化学会、日本分子生物学会、日本内分泌学会、米国内分泌学会

■ 専門分野
生化学、分子生物学

■ 主な研究テーマ・活動
エストロゲンの生理作用の解析

■ 研究についてのPR

■ 社会人・生徒を対象として可能な講演・授業(例えば講演題目)

■ 研究業績
1) K. Toda, Y. Okada, M. Zubair, K.I.Morohashi, T. Saibara, T. Okada: Aromatase-Knockout Mouse Carrying an Estrogen-Inducible Enhanced Green Fluorescent Protein Gene Facilitates Detection of Estrogen Actions in Vivo. Endocrinology. (2004) 145, 1880-1888
2) K. Toda, T. Okada, C. Miyaura, and T. Saibara: Fenofibrate, a ligand for PPARa, inhibits aromatase cytochrome P450 expression in the ovary of mouse J. Lipid Res. (2003) 44: 265-270
3) K.Takeda, K. Toda, T. Saibara, M. Nakagawa, K. Saika, S. Onishi, T. Sugiura and Y. Shizuta: Progressive development of insulin resistant phenotype in male mice with complete aromatase(CYP19) deficiency. J. Endocrinol (2003) 176, 237-246.
4) K. Yamada, Y. Kondo, K. Toda, Y. Sakuma: Behavioral ewvaluation of sociosexual dysfunction in aromatase knockout mice Jpn J Reprod. Endocrinol (2003) 8, 61-66
5) K. Toda, C. Miyaura, T. Okada and Y. Shizuta Dietary bisphenol A prevents ovarian degeneration and bone loss in female mice lacking the aromatase gene (Cyp19). Eur. J. Biochemistry (2002) 269, 2214-2222
8) K. Toda, K. Takeda, T. Okada, S. Akira, T. Saibara, T. Kaname, K. Yamamura, S. Onishi and Y. Shizuta: Targeted disruption of the aromatase P450 gene (Cyp19) in mice and their ovarian and uterine responses to 17b-oestradiol. J. Endocrinol. (2001) 170, 99-111
7) K. Toda, T. Okada, K. Takeda, S. Akira, T. Saibara, M. Shiraishi, S. Onishi and Y. Shizuta: Oestrogen at neonatal stage is critical for reproductive ability of male mice as revealed by supplementation with 17b-oestradiol to aromatase (CYP19) gene knockout mice. J. Endocrinol. (2001) 168, 455-463.
8) K. Toda, T. Okada, T. Saibara, S. Onishi and Y. Shizuta: A loss of aggressive behaviour and its reinstatement by estrogen in mice lacking the aromatase gene (Cyp 19). J. Endocrinol. (2001) 168, 217-220
9) K. Toda, K. Takeda, S. Akira, T. Saibara, T. Okada, S. Onishi and Y. Shizuta: Alterations in hepatic expression of fatty-acid metabolising enzymes in ArKO mice and their reversal by the treatment with 17b-estradiol or a peroxisome proliferator. J. Steroid. Biochem. Mol. Biol. (2001) 79; 11-17
10) C. Miyaura, K. Toda, M. Inada, T. Ohshiba, C. Matsumoto, T. Okada, M. Ito, Y. Shizuta and A. Ito: Sex- and age-related response to aromatase-deficiency in bone. Biochem. Biophys. Res. Commun. (2001) 280, 1062-1068.
11) K. Toda, S. Okada, K. Nakamura, M. Nishihara, K. Yokotani, and Y. Shizuta: Concentrations of monoamines and acetylcoline in the brains of mice lacking the aromatase cytochrome P450 gene. In "Molecular Steroidogenesis" (eds. M. Okamoto, Y. Ishimura, and H. Newada) pp. 141-143, (2000) Frontiers Science Series No. 29, Universal Academy Press, Inc, Tokyo, Japan. (International Symposium on Molecular Steroidogenesis, Proceedings of the 52nd Yamada Conference at Nara)
12) Y. Nemoto, K. Toda, M. Ono, K. F-Adachi T. Saibara, S. Onishi, H. Enzan, T. Okada and Y. Shizuta: Altered expression of fatty acid-metabolizing enzymes in aromatase-deficient mice. J. Clin. Invest. (2000) 105, 1819-1825.
13) K. Toda, J. Fukata, S. Onishi Y. Sagara and Y. Shizuta: Cooperative regulation of human aromatase cytochrome P450 gene expression by placenta-specific cis-acting elements. J. Steroid. Biochem. Mol. Biol. (1997) 61, 211-217
14) K. Toda, S. Nomoto, and Y. Shizuta: Identification and characterization of transcriptional regulatory elements of the human aromatase cytochrome P-450 gene. J. Steroid. Biochem. Mol. Biol. (1996) 56, 151-159.


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